Left Heart Bypass Using the Oscillated Blood Flow with Totally Implantable Vibrating Flow Pump

Yambe, Tomoyuki; Owada, Naoki; Kobayashi, Shin; Sonobe, Taro; Naganuma, S.; Nanka, S.; Hashimoto, Hiroyuki; Yoshizawa, Makoto; Tabayashi, K.; Takayasu, Hideki; Takeda, Hiroshi; Nitta, Shin Ichi

doi:10.1046/j.1525-1594.1998.06148.x

Cited by 15 publications

(7 citation statements)

References 12 publications

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“…An important limiting factor in reducing the size of the pump was its drive mechanism (11)(12)(13)(14)(15)(16)(17)(18)(19). We adopted the cross slider form with motor to make a small size driving mechanism.…”

Section: Discussionmentioning

confidence: 99%

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

et al. 2001

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This study describes the present state of progress in the development of the vibrating flow pump (VFP) ventricular assist system. We have proceeded with development aiming at a totally implantable ventricular assist system with smaller size and lighter weight appropriate for Asians like the Japanese by increasing the drive frequency. An actuator is important for the development of the miniature sized and lightweight artificial heart. We applied a linear motor for the mechanical part at first. The step motor was applied after that. This form may be best if we want the lightweight small sized motor for an actuator. The cross slider form is applied at present. It succeeded in the miniaturization compared with the linear motor. In the VFP-type ventricular assist system, the blood contact parts are a central vibration tube with inflow and outflow chambers. We designed round diaphragms to prevent thrombus formation. In addition, we developed an energy transmission system for total implantation. The VFP creates a high frequency oscillated blood flow. It has a unique flow pattern. Brain blood flow increased although the total flow of the circulation did not change in the frequency of 25 to 30 Hz. The quantitative evaluation of the autonomic nerve function during the left heart assistance with an oscillated blood flow was carried out by spectral analysis. Some influences on an autonomic nerve were observed by the VFP left heart assistance. We will continue development research with the aim of clinical application.

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Section: Discussionmentioning

confidence: 99%

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

et al. 2001

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“…[13][14][15] In natural heart contraction, the myocardium works by itself. However, the current implantable artificial heart systems are too large for Japanese people.…”

Section: Discussionmentioning

confidence: 99%

Treatment of multiple organ failure by a totally implantable ventricular assist device

et al. 2001

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Multiple organ failure (MOF) becomes an important problem during clinical use of the Ventricular assist device (VAD). To improve the clinical record of the VAD, the function of other organs may be vitally important. For that reason, we have been developing a VAD system aiming at improving the function of other organs. Development of the vibrating flow pump (VFP), which can generate a unique flow pattern from 10 to 50Hz, is still ongoing in our institute. In order to evaluate brain blood flow and oxygen consumption, oxyhemoglobin was measured with NIRO (Hamamatsu Photo.) in healthy adult goats. Four healthy adult goats were anesthetized with halothane inhalation, and left thoracotomy was performed for left heart bypass. Oxyhemoglobin in the brain was measured with the recording of the hemodynamic variables during left heart assistance with the VFP system. During left heart bypass with the VFP system, the hemodynamic parameters kept within the normal range, and satisfactory pump output was easily obtained. Pump output was kept within 40%-50% bypass to evaluate the effect of high-frequency oscillating assist flow on brain blood flow with the same cardiac output. Interesting results were observed during the experiments.During 30Hz driving of the VFP left heart assistance, oxyhemoglobin suggested that brain blood flow was significantly increased compared with another drive frequency with the same total cardiac output. These results suggest that we can control brain blood flow with a totally implantable VAD system such as the VFP system, which can control the frequency of the blood flow.

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“…Bridging use of ventricular assist systems in heart transplantation may become necessary for a long time because of the shortage of donated hearts. In this situation, the quality of life of the patients waiting for a donor heart becomes increasingly important, so development of a totally implantable system is highly desirable (6–11). Toward this end, miniaturization of actuators is fundamental, especially for people with small physiques such as average Japanese people (6–8).…”

Section: Artificial Myocardiummentioning

confidence: 99%

Recent Progress in Artificial Organ Research at Tohoku University

et al. 2003

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Tohoku University has developed various artificial organs over the last 30 years. Pneumatic driven ventricular assist devices with a silicone ball valve have been designed by the flow visualization method, and clinical trials have been performed in Tohoku University Hospital. On the basis of these developments, a pneumatic driven total artificial heart has been developed and an animal experimental evaluation was conducted. The development of artificial organs in Tohoku University has now progressed to the totally implantable type using the transcutaneous energy transmission system with amorphous fibers for magnetic shielding. Examples of implantable systems include a vibrating flow pump for ventricular assist device, an artificial myocardium by the use of shape memory alloy with Peltier elements, and an artificial sphincter for patients with a stoma. An automatic control system for artificial organs had been developed for the ventricular assist devices including a rotary blood pump to avoid suction and to maintain left and right heart balance. Based upon the technology of automatic control algorithm, a new diagnostic tool for evaluating autonomic nerve function has been developed as a branch of artificial organ research and this new machine has been tested in Tohoku University Hospital. Tohoku University is following a variety of approaches aimed at innovation in artificial organs and medical engineering fields.

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Left Heart Bypass Using the Oscillated Blood Flow with Totally Implantable Vibrating Flow Pump

Cited by 15 publications

References 12 publications

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

Recent Progress on the Vibrating Flow Pump as a Totally Implantable Ventricular Assist Device

Treatment of multiple organ failure by a totally implantable ventricular assist device

Recent Progress in Artificial Organ Research at Tohoku University

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