Left lateralized P300 amplitude deficit in schizophrenic patients depends on pitch disparity

Weisbrod, Matthias; Winkler, S.; Maier, Sabine; Hill, Holger; Thomas, Christine; Spitzer, Manfred

doi:10.1016/s0006-3223(96)00064-9

Cited by 24 publications

(10 citation statements)

References 43 publications

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“…Subsequent studies have shown that the lateralized P300 deficit appears in off-medication schizophrenic patients , in first-episode schizophrenic patients (Salisbury et al, 1998), and in never-medicated schizotypal subjects (Salisbury, Voglmaier, Seidman, & McCarley, 1996), when a nose reference (Faux et al, 1990) and a 64-channel recording (Potts, Hirayasu, O'Donnell, Shenton, & McCarley, 1998) is used. The left < right P300 asymmetry has been replicated by many investigators using similar paradigms (e.g., Bolsche, MacCrimmon, & Kropf, 1996;Bruder et al, 1996; Ford and Sidman, 1988;Gerez and Tello, 1995; Kraft, Schwartzskopf, Torello, Olsen, & Nasrallah, 1991;Muir, St. Clair, & Blackwood, 1991;Scherg & Berg, 1996;Sieg, Willsie, Preston, & Gaffney, 1991;Souza et al, 1995;Strik, Dierks, Franzek, Stober, & Maurer, 1994aTuretsky, Colbath, Erwin, & Gur, 1998;Weisbrod et al, 1997). Bruder et al (1996) noted that in most studies in which the asymmetry was not replicated, the design incorporated a button-press response (e.g., Ford et al, 1994a;Pfefferbaum et al, 1989).…”

Section: P300 Component In Schizophreniamentioning

confidence: 82%

Section: P300 Component In Schizophreniamentioning

confidence: 99%

“…Bruder et al (1996) noted that in most studies in which the asymmetry was not replicated, the design incorporated a button-press response (e.g., Ford et al, 1994a;Pfefferbaum et al, 1989). Increased task difficulty may also reduce P300 asymmetry (Salisbury et al, 1994;Weisbrod et al, 1997).In a study comparing first-episode schizophrenic patients, first-episode affective psychotic patients, and age matched controls, Salisbury et al (1998) found that first-episode schizophrenic patients displayed smaller P300 amplitude over the left temporal region (T3) than did either first-episode affective patients or normal control subjects. The first psychotic episode affective disorder patients, although showing an overall P300 amplitude reduction, did not show a left < right asymmetry (see Figure 2).…”

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Identification of neural circuits underlying P300 abnormalities in schizophrenia

et al. 1999

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Event-related potentials (ERPs) provide a noninvasive method to evaluate neural activation and cognitive processes in schizophrenia. The pathophysiological significance of these findings would be greatly enhanced if scalp-recorded ERP abnormalities could be related to specific neural circuits and/or regions of the brain. Using quantitative approaches in which scalp-recorded ERP components are correlated with underlying neuroanatomy in schizophrenia, we focused on biophysical and statistical procedures (partial least squares) to relate the auditory P300 component to anatomic measures obtained from quantitative magnetic resonance imaging. These findings are consistent with other evidence that temporal lobe structures contribute to the generation of the scalp-recorded P300 component and that P300 amplitude asymmetry over temporal recording sites on the scalp may reflect anatomic asymmetries in the volume of the superior temporal gyrus in schizophrenia. DescriptorsEvent-related potentials; P300; MRI; Neuroanatomy; Schizophrenia Event-related potential (ERP) techniques have been used in the study of schizophrenia for several decades, but determining the relationship of ERP abnormalities to specific anatomic abnormalities has only recently been undertaken. Here, we survey methods for establishing the relationship of scalp-recorded ERPs and neuroanatomy, focusing on the auditory P300 component. We first review P300 amplitude and topography disturbances in schizophrenia and evidence from a variety of techniques which have indicated an association of the P300 component with temporal lobe structures. We next review biophysical source analysis Copyright © 1999 Society for Psychophysiological Research Address reprint requests to: R.W. McCarley, Psychiatry (116A), Brockton VA Medical Center, 940 Belmont Street, Brockton, MA02401, mccarley@warren.med.harvard.edu; or B. F. O'Donnell, Department of Psychology, University of Indiana, Bloomington, IN 47405, bodonnel@indiana.edu. The SPSS code for the PLS procedure described in this paper is available from the corresponding authors. NIH Public Access Author ManuscriptPsychophysiology. Author manuscript; available in PMC 2010 April 6. Published in final edited form as:Psychophysiology. 1999 May ; 36(3): 388-398. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript approaches, with a demonstration of bioelectric modeling of the P300 component on an individual head and brain. We conclude with an application of a recently developed multivariate statistical technique, partial least squares analysis. This technique can be applied to define the relationships among large numbers of structural and electrophysiological measures in the relatively small sample size typical in brain imaging studies. In the example presented here, partial least squares analysis was used to relate volumetric measures of temporal lobe gray matter structures to the P300 and N200 components recorded over a 10-20 montage. P300 Component in SchizophreniaSchizophrenia is a severe behavi...

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Section: P300 Component In Schizophreniamentioning

confidence: 82%

Section: P300 Component In Schizophreniamentioning

confidence: 99%

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Identification of neural circuits underlying P300 abnormalities in schizophrenia

et al. 1999

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“…It has been related functionally to memory updating (Donchin 1981), and its latency and amplitude have been related to stimulus evaluation (Kutas et al 1977). In particular, the P300 left temporal amplitude reduction appears to be selective to schizophrenia relative to affective psychosis in both first episode and chronic subjects (Ford et al 1982;Salisbury et al 1998) and has been found in most (Faux et al 1988;Heidrich and Strik, 1997;Salisbury et al 1992Salisbury et al , 1994Strik et al 1994;Turetsky et al 1998;Weisbrod et al 1997) but not all (e.g., Pfefferbaum et al 1989;Stefansson et al 1996) studies of schizophrenia.…”

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Lateralized P3 deficit in schizotypal personality disorder

Niznikiewicz

Voglmaier

Shenton

et al. 2000

Biological Psychiatry

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“…P300 is robustly small in schizophrenia (Begleiter & Porgesz, 1986;Roth & Cannon, 1972;Salisbury, Shenton, & McCarley 1999). Salisbury et al (1994) and Weisbrod et al (1997) showed that this reduced amplitude was not due to reduced information transfer. The performance of schizophrenic subjects could be approximated with that of controls by increasing the pitch separation and the intensity of the stimuli.…”

Section: Introductionmentioning

confidence: 99%

The effect of background noise on P300 to suprathreshold stimuli

et al. 2002

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Both the amplitude and latency of P300 vary with changes in stimulus parameters. Stimuli at intensities or pitch separations near threshold evoke a smaller and later P300. P300 is also affected by extraneous stimulus parameters in tasks where stimulus frequency separation is large and stimuli are well above intensity thresholds. For example, the presence of background white noise when tones are suprathreshold and easily detectable has been reported to increase P300 latency. However, the effects of background masking noise on P300 amplitude and scalp topography have not been reported. Subjects performed an oddball task both in the presence and in the absence of background noise. Performance accuracy was unaffected by background noise. P300 showed latency increases when noise was present, but P300 peak amplitude was unaffected. P300 scalp topography was stable across both conditions. P300 latency is affected by background noise, even when performance is not, but amplitude and amplitude topography remain unaffected.The P300 event-related potential (ERP) has been related to endogenous or cognitive operations in contrast to exogenous or sensory factors (Donchin & Coles, 1988;Sutton, Braren, Zubin, & John, 1965). P300 generally reflects the higher-order cognitive operations related to selective attention and resource allocation rather than differences in stimulus characteristics per se. However, P300 is not completely independent from stimulus parameters. P300 is most affected by stimulus parameters at values close to sensory threshold. Hillyard and colleagues demonstrated that at near intensity threshold, P300 amplitude was linearly coupled to stimulus discriminability. As stimuli became suprathreshold, the amplitude of P300 became decoupled from intensity. P300 amplitude showed a curvilinear relation to stimulus intensity, directly related when stimuli were not easily detected, but independent when stimuli were suprathreshold (Hillyard, Squires, Bauer, & Lindsey, 1971;Sugg & Polich, 1995). P300 latency is also affected, showing decreases as stimuli become progressively suprathreshold (e.g., Adler & Adler, 1991;Salisbury et al., 1994). Johnson (1986Johnson ( ,1993 summarized the interrelated factors affecting P300 amplitude in his Triarchic model. The three factors were information transfer (related to stimulus parameters and inattention); subjective meaning (related to task demands and relevance); and subjective probability (related to the perceived infrequency of the target stimulus). The latter two are thought to be independent and modulated by information transfer.The following example illustrates the examination of stimulus parameter effects in relation to the factors affecting P300. P300 is robustly small in schizophrenia (Begleiter & Porgesz, 1986;Roth & Cannon, 1972;Salisbury, Shenton, & McCarley 1999). Salisbury et al. (1994) and Weisbrod et al. (1997) showed that this reduced amplitude was not due to reduced information transfer. The performance of schizophrenic subjects could be approximated with ...

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Left lateralized P300 amplitude deficit in schizophrenic patients depends on pitch disparity

Cited by 24 publications

References 43 publications

Identification of neural circuits underlying P300 abnormalities in schizophrenia

Identification of neural circuits underlying P300 abnormalities in schizophrenia

Lateralized P3 deficit in schizotypal personality disorder

The effect of background noise on P300 to suprathreshold stimuli

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