Left-Right Asymmetry in Chicken Embryonic Gonads

Intarapat, Sittipon; Stern, Claudio D.

doi:10.2141/jpsa.0140032

Cited by 8 publications

(4 citation statements)

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“…It suggests that the two testes are functionally different, with the left being more functional than the right. Recent studies have shown that after gonadal differentiation, stem cell numbers, and gene expression profiles are higher in the left gonad in both sexes (Intarapat and Stern , ). This difference in early development may translate into a functional difference in adulthood, resulting in a higher functionality in the left gonad in both sexes.…”

Section: Resultsmentioning

confidence: 99%

Divergent artificial selection for female reproductive investment has a sexually concordant effect on male reproductive success

2017

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Depending on the genetic architecture of male and female fitness, sex‐specific selection can have negative, positive, or neutral consequences for the opposite sex. Theory predicts that conflict between male and female function may drive the breakdown of intrasexual genetic correlations, allowing sexual dimorphism in sexually antagonistic traits. Reproductive traits are the epitome of this, showing highly differentiated proximate functions between the sexes. Here we use divergent artificial selection lines for female reproductive investment to test how female‐specific selection on a sex‐limited trait affects male reproductive success in a precocial bird, the Japanese quail (Coturnix japonica). We demonstrate that selection for increased egg investment in females positively affects male reproductive success both in competitive and non‐competitive mating situations. This increased reproductive success was linked to a relatively larger left testis in males originating from lines selected for high female reproductive investment. Given that female quail have functional gonads only on their left side, this correlated response indicates that selection has acted on the shared developmental basis of male and female gonads. Our study thereby provides evidence for a positive genetic correlation between key reproductive traits in males and females despite a high degree of sexual dimorphism, and suggests that, in this system, selection on reproductive function is sexually concordant.

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Section: Resultsmentioning

confidence: 99%

Divergent artificial selection for female reproductive investment has a sexually concordant effect on male reproductive success

2017

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“…The cortex is thickened only in the left gonad, and the right one is flattened (Ishimaru et al, 2008;Guioli et al, 2014). In addition, there are a greater number of germ cells in the left gonad (Nakamura et al, 2007;Intarapat and Stern, 2014). The right ovary lacks the thickened cortex, but the cortical region of the left ovary continues to develop; therefore, only germ cells in the left cortex can enter meiosis (Smith et al, 2008), and only the left ovary is functional.…”

Section: Introductionmentioning

confidence: 99%

Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo

Omotehara

Minami

Mantani

et al. 2017

Developmental Dynamics

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“…Strikingly, estrogen and its receptor are asymmetrically expressed in avian embryonic gonads during sexual differentiation Nakabayashi et al, 1998). Asymmetric expression of estrogen and its receptor in chicken embryonic gonads is related to left-right gonadal asymmetry in birds (Intarapat & Stern, 2014).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Localization of Estrogen Receptor in the Embryonic Gonad of Male Quail Embryo During Gonadal Differentiation

2016

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INTARAPAT, S.; SAILASUTA, A. & SATAYALAI, O.Immunohistochemical localization of estrogen receptor in the embryonic gonad of male quail embryo during gonadal differentiation. Int. J. Morphol., 34(2):575-579, 2016. SUMMARY:In birds, male embryo the gonads develop bilateral testes, in which both left and right sides produce functional spermatozoa, whereas female embryo, only the left gonad develops into a functional ovary. Estrogen plays a key role in avian sex determination in both sexes by binding to the estrogen receptor (ER). Surprisingly, chicken estrogen receptor (cER) mRNA is expressed in both sexes; moreover; its expression is only expressed in the left male gonad. The present study aimed to localize ER protein in the left gonad of male quail embryo using immunohistochemistry. The 8-day-old male quail embryos whose embryonic sex distinguished by gonadal morphology were studied. Histology of the left male gonad displayed thin cortex containing 1 to 2 layers of the germinal epithelium, while testicular cords were observed in the medulla. ER-immunoreactive cells were only found in the germinal epithelium but not in the medulla. Localization of ER was detected in the nucleus and cytoplasm of the germinal epithelial cells. The number of ER-immunoreactive cells counted in upper, lateral, and lower regions of the germinal epithelium was 18.20±1.892, 17.60±1.887, and 16.20±1.290, respectively. This study shows the first evidence for expression of ER protein in the left male gonad of the avian embryo, indicating that ER plays a role in avian gonadal sex differentiation.

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Left-Right Asymmetry in Chicken Embryonic Gonads

Cited by 8 publications

References 88 publications

Divergent artificial selection for female reproductive investment has a sexually concordant effect on male reproductive success

Divergent artificial selection for female reproductive investment has a sexually concordant effect on male reproductive success

Contribution of the coelomic epithelial cells specific to the left testis in the chicken embryo

Immunohistochemical Localization of Estrogen Receptor in the Embryonic Gonad of Male Quail Embryo During Gonadal Differentiation

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