Left ventricle relative wall thickness and plasma leptin levels

Blasio, Andrea Di; Donato, Francesco Di; Stefano, Angela De; Gallina, Sabina; Granieri, Monica; Napolitano, Giorgio; Petrella, Vittorio; Riccardi, Irene; Santarelli, Francesco; Valentini, Pasquale; Ripari, Patrizio

doi:10.1097/gme.0b013e3181e57813

Cited by 11 publications

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“…Among the 19 studies ( Table 1 ), 18 applied training intervention [ 32 – 45 , 47 – 50 ], one compared the leptin levels of a mildly obese sedentary and a physically active group with similar BMI [ 46 ]. Regarding training, 13 studies applied a single (10-week to 6-month) training period [ 32 , 35 , 36 , 39 , 40 – 45 , 48 – 50 ], while 5 studies applied a 2-phase, 12-18-month training with the first leptin test after the first 3 or 6 months [ 33 , 34 , 37 , 38 , 47 ]. The second phase of training failed to induce further significant decline in leptin levels.…”

Section: Resultsmentioning

confidence: 99%

“…The second phase of training failed to induce further significant decline in leptin levels. Ten studies provided additional pre- and post-training adiponectin levels [ 32 , 33 , 36 , 38 , 40 , 41 , 44 , 45 , 48 , 49 ], 13 reported indicators of carbohydrate metabolism ( Table 2 ) [ 36 – 45 , 48 – 50 ], 11 reported training-induced BMI changes [ 35 , 36 , 39 – 45 , 49 , 50 ], a partially different subset of 11 studies described training-induced changes in fat mass [ 34 , 39 – 45 , 48 – 50 ]. From the 18 studies that investigated the effects of training on leptin levels [ 32 – 45 , 47 – 50 ] only 3 of them failed to detect significant effect [ 43 , 45 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding gender, 6 studies reported data of men [ 36 , 40 , 41 , 43 , 44 , 46 ], 5 reported data of women [ 32 , 35 , 37 , 38 , 50 ], the remaining 8 merged data of men and women [ 33 , 34 , 39 , 42 , 45 , 47 – 49 ].…”

Section: Resultsmentioning

confidence: 99%

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In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis

et al. 2017

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BackgroundLeptin is one of the major adipokines in obesity that indicates the severity of fat accumulation. It is also an important etiological factor of consequent cardiometabolic and autoimmune disorders. Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia. Hyperleptinemia, on the other hand, may promote the development of age-related abnormalities. While major weight loss has been demonstrated to ameliorate hyperleptinemia, obese people show a poor tendency to achieve lasting success in this field. The question arises whether training intervention per se is able to reduce the level of this adipokine.ObjectivesWe aimed to review the literature on the effects of training intervention on peripheral leptin level in obesity during aging, in order to evaluate the independent efficacy of this method. In the studies that were included in our analysis, changes of adiponectin levels (when present) were also evaluated.Data sources3481 records were identified through searching of PubMed, Embase and Cochrane Library Database. Altogether 19 articles were suitable for analyses.Study eligibility criteriaEmpirical research papers were eligible provided that they reported data of middle-aged or older (above 45 years of age) overweight or obese (body mass index above 25) individuals and included physical training intervention or at least fitness status of groups together with corresponding blood leptin values.Statistical methodsWe used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods. I-squared indicator and Q test were performed to assess heterogeneity. To assess publication bias Egger’s test was applied. In case of significant publication bias, the Duval and Tweedie's trim and fill algorithm was used.ResultsTraining intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. Resistance training appears to be more efficient in reducing blood leptin level than aerobic training alone.ConclusionsPhysical training, especially resistance training successfully reduces hyperleptinemia even without diet or major weight loss.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis

et al. 2017

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“…24 Similarly, studies of postmenopausal women with an average body mass index of 27, as well as men and women with a body mass index of 26 and over the age of 70 years, reported significant inverse associations between leptin and LV mass. 25,26 …”

Section: Discussionmentioning

confidence: 99%

Relation of Leptin to Left Ventricular Hypertrophy (from the Multi-Ethnic Study of Atherosclerosis)

Allison

Bluemke

McClelland

et al. 2013

The American Journal of Cardiology

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Increasing adiposity increases the risk for left ventricular hypertrophy. Adipokines are hormone-like substances from adipose tissue that influence several metabolic pathways relevant to LV hypertrophy. Data was from participants enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent magnetic resonance imaging of the heart and who also had fasting venous blood assayed for 4 distinct adipokines (adiponectin, leptin, tumor necrosis factor – alpha and resistin). 1,464 MESA participants had complete data. The mean age was 61.5 years, the mean body mass index was 27.6 kg/m2 and 49% were female. With adjustment for age, sex, race, height and weight, multivariable linear regression modeling revealed that a 1-SD increment in leptin was significantly associated with smaller LV mass (ß: −4.66 % predicted, p-value: < 0.01), LV volume (−5.87 % predicted, < 0.01), stroke volume (−3.23 ml, p < 0.01) and cardiac output (−120 mL/min, p = 0.01) as well as a lower odds ratio for the presence of LV hypertrophy (OR: 0.65, p < 0.01), but a higher ejection fraction (0.44%, p = 0.05). Additional adjustment for the traditional cardiovascular disease (CVD) risk factors, insulin resistance, physical activity, education, income, inflammatory biomarkers, other selected adipokines and pericardial fat did not materially change the magnitude or significance of the associations. The associations between the other adipokines and LV structure and function were inconsistent and largely non-significant. In conclusion, the results indicate that higher levels of leptin are associated with more favorable values of several measures of LV structure and function.

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“…Some cross-sectional studies in humans showed that higher leptin was associated with higher left ventricular (LV) mass and wall thickness [10, 11]. In contrast, other cross-sectional studies showed higher leptin was associated with lower LV mass and wall thickness [12, 13]. Two other human studies showed that higher leptin was associated with lower LV mass, wall thickness, volume, stroke volume and cardiac output several years before leptin was measured [14, 15].…”

Section: 1 Introductionmentioning

confidence: 99%

Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA)

Sharma

Colangelo

Allison

et al. 2015

International Journal of Cardiology

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Background/Objectives Earlier studies differ on whether serum leptin is associated with adverse or beneficial cardiac structure. We determined the association between serum leptin with subsequent cardiac structure and function. Methods Multicenter longitudinal study of Black, White, Hispanic and Asian-American men and women. Cardiac MRI (CMR) was completed 6 to 8 years after leptin was measured. Left ventricular (LV) mass and volumes were indexed to body surface area. Multivariable linear regression models were constructed to assess the associations between leptin and risk factor adjusted (age, race, gender, systolic blood pressure, anti-hypertensive usage, LDL, HDL, hyperlipidemia medication usage, diabetes, diabetic medication usage, chronic kidney disease, alcohol and tobacco use, adiponectin and BMI) CMR variables. Results Relative to participants in the lowest quintile of leptin concentration, participants in the highest quintile had a lower risk factor adjusted LV mass (-14g), LV mass index (-9g/m2), LV end diastolic volume index (LVEDVi) (-7 ml/m2), LV end systolic volume index (LVESVi) (-3 ml/m2) and stroke volume (-5 ml) (all p≤ 0.05). On regression analysis, a doubling of leptin concentration was associated with lower LV mass (-2.5g±0.7g), LV mass index (-1.7±0.3 g/m2), LVEDVi (-1.5±0.4 ml/m2), LVESVi (-0.7±0.2 ml/m2) and stroke volume (-1.0±0.5ml) (all p≤ 0.05). Conclusions Higher leptin was associated with more favorable subsequent cardiac structure. Further study is needed to assess the prognostic and therapeutic implications of these observations.

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Left ventricle relative wall thickness and plasma leptin levels

Abstract: In healthy overweight sedentary postmenopausal women with low fitness level, high plasma leptin levels seem to have a protective role against left ventricle relative wall thickness hypertrophy and to participate in its remodeling after 4 months of aerobic training.

Cited by 11 publications

References 50 publications

In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis

In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis

Relation of Leptin to Left Ventricular Hypertrophy (from the Multi-Ethnic Study of Atherosclerosis)

Association of serum leptin with future left ventricular structure and function: The Multi-Ethnic Study of Atherosclerosis (MESA)

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