Left ventricular contractility is reduced by hypercapnic acidosis and thoracolumbar epidural anesthesia in rabbits

Mizukoshi, Yuzo; Sato, Keizo; Yoshida, Masahiro

doi:10.1007/bf03016832

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…35 58 This concept was supported by the observation in rabbits that although hypercapnoeic acidosis caused a 16% decrease in contractility, a thoracolumbar epidural increased this depression considerably by blocking sympathetic activity. 68 The depression of myocardial contractility produced by respiratory acidosis is also significantly increased after beta-blockade implying a systemic catecholamine effect. 102 In the pulmonary vasculature, however, acidosis increases the response to norepinephrine.…”

Section: Acidosis and Inotropesmentioning

confidence: 99%

Physiological effects of hyperchloraemia and acidosis

Handy

Soni

2008

British Journal of Anaesthesia

176

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The advent of balanced solutions for i.v. fluid resuscitation and replacement is imminent and will affect any specialty involved in fluid management. Part of the background to their introduction has focused on the non-physiological nature of 'normal' saline solution and the developing science about the potential problems of hyperchloraemic acidosis. This review assesses the physiological significance of hyperchloraemic acidosis and of acidosis in general. It aims to differentiate the effects of the causes of acidosis from the physiological consequences of acidosis. It is intended to provide an assessment of the importance of hyperchloraemic acidosis and thereby the likely benefits of balanced solutions.

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Section: Acidosis and Inotropesmentioning

confidence: 99%

Physiological effects of hyperchloraemia and acidosis

Handy

Soni

2008

British Journal of Anaesthesia

176

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“…Conversely, it can be shown that the contractility changes caused by acidosis are offset by increased catecholamine production. This concept was supported by the observation in rabbits that although hypercapnic acidosis caused a decrease in contractility, thoracolumbar epidural anesthesia increased this depression considerably by blocking sympathetic activity [31].…”

Section: Metabolic Acidosis Organ Dysfunction and Outcomes Of Septicmentioning

confidence: 95%

Metabolic Acidosis in Sepsis

Maciel¹,

Noritomi²,

Park³

2010

EMIDDT

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Metabolic acidosis is very common in critically ill septic patients. Acidosis may be a result of the underlying pathophysiology, but it also may be the result of the way in which those patients are managed. Chloride-associated acidosis is frequent and is potentially aggravated during fluid resuscitation. The severity of metabolic acidosis is associated with poor clinical outcomes; however, it remains uncertain whether or not there is a causal relationship between acidosis and the pathophysiology of septic syndromes. Several experimental findings have demonstrated the impact of acidosis modulation on the release of inflammatory mediators and cardiovascular function. Treatment of metabolic acidosis is based on control of the underlying process and support of organ dysfunction, although the use of intravenous chloride-poor balanced solutions seems an attractive option to prevent the worsening of metabolic acidosis during fluid resuscitation.

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