1992
DOI: 10.1093/oxfordjournals.eurheartj.a060249
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Left ventricular diastolic and systolic function in normotensive obese subjects: influence of degree and duration of obesity

Abstract: The present study was carried out to evaluate systolic and diastolic parameters in overweight and moderately obese, but otherwise healthy subjects, and in a lean control group, to determine whether degree and duration of obesity can influence left ventricular function. A total of 27 subjects, 17 overweight or with moderate obesity and 10 lean, healthy subjects were included. Patients were divided into three groups according to their body mass index (BMI) and to Garrow's criteria as follows: lean control group … Show more

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Cited by 85 publications
(73 citation statements)
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“…Furthermore, decrements in systolic and diastolic functions have been documented in obese subjects even in the absence of hypertension. 16 Indeed, the Framingham study has determined that obesity is an independent risk factor for congestive heart failure. 17 Another possible cause of cardiac dysfunction in obesity could be related to the consistent increase in cardiac output seen in obesity.…”
Section: Ectopic Fat Storage In the Heartmentioning
confidence: 99%
“…Furthermore, decrements in systolic and diastolic functions have been documented in obese subjects even in the absence of hypertension. 16 Indeed, the Framingham study has determined that obesity is an independent risk factor for congestive heart failure. 17 Another possible cause of cardiac dysfunction in obesity could be related to the consistent increase in cardiac output seen in obesity.…”
Section: Ectopic Fat Storage In the Heartmentioning
confidence: 99%
“…Decrements in systolic function in obesity include lower ejection fraction, peak ejection rate and fractional shortening, and higher end systolic diameter. 1,2 Even in the absence of hypertension, cardiac hypertrophy, a hyperkinetic circulation, and reduced cardiac function have been documented in obese humans. 1,3,4 Further, the Framingham study has determined that obesity is an independent risk factor for congestive heart failure.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the manner and the extension of the negative influence of obesity on the diastolic and/or systolic function in the left and right ventricle remains debated and unclear. [6][7][8][9][10][11][12][13] To the best of our knowledge, this study represents the first attempt to perform such a complete and detailed echocardiographic evaluation to determine the existence and the extent of an obesityrelated adjunctive depressive effect on left-and right systo-diastolic ventricular dysfunction in hypertensive patients with cutting-edge diagnostic techniques, such as tissue Doppler velocity and strain imaging.…”
Section: Diffusion and Accuracy Confirmation Of Tissue Doppler Imaginmentioning
confidence: 99%
“…4 Moreover, obesity has been associated with heart failure, 5 left-ventricular dilation, increased leftventricular wall stress and compensatory (eccentric) left-ventricular hypertrophy. 6,7 Impairment of cardiac function has been reported to correlate with BMI and the duration of obesity, 7,8 with most studies demonstrating abnormal diastolic function, 9,10 without a consistent association with systolic dysfunction. 7,8 A condition characterized by chronic leftventricular volume overload, eccentric hypertrophy and progressive diastolic impairment, commonly leading to heart failure, have also been described as a unique entity named 'obesity cardiomyopathy' .…”
Section: Introductionmentioning
confidence: 99%
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