Left ventricular dyssynchrony and 2D and 3D global longitudinal strain for differentiating physiological and pathological left ventricular hypertrophy

Ternacle, Julien; Brémont, Camille; d’Humières, Thomas; Faivre, Laureline; Doan, Huy Long; Gallet, Romain; Oliver, Léopold; Dubois‐Randé, Jean‐Luc; Lim, Pascal

doi:10.1016/j.acvd.2016.11.003

Cited by 18 publications

(14 citation statements)

References 25 publications

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“…17 In a 3DSTE study, Ternacle et al even found no significant differences in GLS, GCS, GAS, and GRS between the athletes with LVN and the controls. 18 Similarly, in our study, GLS was the only significantly lower strain value in the T2DM patients with LVN than in the controls.…”

Section: Dysfunction In T2dmsupporting

confidence: 76%

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

et al. 2019

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Purposes The purposes of our study were to determine the risk factors related to metabolic left ventricular remodeling (LVR) in type 2 diabetes mellitus (T2DM) patients and to assess the LV function with different geometry in such population. Methods Seventy‐eight T2DM patients with normal 2D‐LVEF (≥55%) were enrolled and divided into two groups with LV normal geometry (LVN) and with LV remodeling (LVR). The control group was composed of forty age‐ and sex‐matched healthy individuals with LVN. A multifactor logistic regression was used to determine the risk factors for LVR, and their diagnostic values were evaluated using the area under the ROC curves (AUC). Three‐dimensional speckle tracking echocardiography (3DSTE) was used to measure LV global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS). Results Fasting plasma glucose (FPG), hyperlipidemia, and BMI were independently associated with LVR in T2DM patients, and the AUC values were 0.699, 0.697, and 0.732, respectively. The T2DM patients with LVN showed significantly lower GLS than the controls (P < 0.05), whereas the T2DM patients with LVR showed significantly lower GLS, GCS, GAS, and GRS than the T2DM patients with LVN (all P < 0.01). Additionally, GLS, GAS, and GRS values decreased significantly in the T2DM patients with LV hypertrophy than in those with LV concentric remodeling (all P < 0.05). Conclusions The routine echocardiography and 3DSTE could be used in combining way to detect the metabolic LV remodeling and accompanied dysfunction in T2DM patients.

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Section: Dysfunction In T2dmsupporting

confidence: 76%

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

et al. 2019

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“…STE appears to be a sensitive technique for the early diagnosis of HCM in people, and it has been used to differentiate left ventricular hypertrophy because of HCM from athletes' heart, cardiac amyloidosis, or storage disease. STE abnormalities have been documented in people with pathogenic HCM mutations who are phenotype‐negative based on conventional echocardiographic imaging …”

Section: Introductionmentioning

confidence: 99%

“…STE abnormalities have been documented in people with pathogenic HCM mutations who are phenotypenegative based on conventional echocardiographic imaging. [23][24][25][26][27][28] Reported applications for left ventricular STE in veterinary medicine have included the investigation of dilated cardiomyopathy, tachycardiainduced cardiomyopathy, degenerative mitral valve disease, and patent ductus arteriosus. 18,19,[29][30][31][32][33][34][35] Three STE studies have reported investigations of cardiac mechanics in cats with HCM.…”

Section: Introductionmentioning

confidence: 99%

Speckle tracking echocardiography in cats with preclinical hypertrophic cardiomyopathy

Spalla

Boswood

Connolly

et al. 2019

Veterinary Internal Medicne

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Background Cats with hypertrophic cardiomyopathy (HCM) have decreased left ventricular (LV) longitudinal deformation detected by mitral annular plane systolic excursion (MAPSE) and speckle tracking echocardiography. People with preclinical HCM have decreased systolic LV longitudinal and radial strain (S) and strain rate (SR), with preserved circumferential S and SR. Hypothesis/Objectives Cats with preclinical HCM have decreased systolic LV deformation compared to normal cats. Animals Seventy‐three client‐owned cats with (n = 37) and without (n = 36) preclinical HCM. Methods Retrospective echocardiographic study. Left and right ventricular longitudinal S and SR, LV radial and circumferential S and SR were calculated by STE. Left ventricular mass was also calculated. Correlation between STE variables and LV hypertrophy was determined and receiver‐operating characteristic (ROC) curves were plotted for prediction of HCM. Results Cats with HCM had smaller absolute longitudinal S (−14.8 ± 3.3% vs −19.7 ± 2.7%, P < .001), longitudinal SR (−2.36 ± 0.62 vs −2.95 ± 0.68 second −1 , P < .001), radial S (46.2 ± 21.3% vs 66.7 ± 17.6%, P < .001), and radial SR (5.60 ± 2.08 vs 6.67 ± 1.8 second −1 , P < .001) compared to healthy controls. No difference was observed for circumferential S and SR. Cats with HCM had greater LV mass (13.2 ± 3.7 g vs 8.6 ± 2.7 g, P < .001). The ROC with the greatest area under the curve (AUC) for the identification of HCM (0.974) was plotted from a logistic regression equation combining LV mass, MAPSE at the free wall, and LV internal diameter in diastole (LVIDd). Conclusions and clinical importance Cats with preclinical HCM have decreased long axis and radial deformation. Decreased longitudinal deformation and decreased LVIDd are factors that would support a diagnosis of HCM.

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“…Studies have found decrease in GLPS, despite normal EF′ in patients with HCM . Furthermore, GLPS has been found to be predictive in differentiation of other etiologies causing left ventricular thickening in patients with HCM, early diagnosis of HCM genetic carriers and the determination of hospitalization due to heart failure, occurrence of ventricular arrhythmia, and major adverse cardiac events . In hypertrophic cardiomyopathy (HCM), microvascular dysfunction in the left ventricle, hypertrophy in the cardio‐myocytes, and disarray in the LV fibers cause myocardial ischemia and fibrosis .…”

Section: Discussionmentioning

confidence: 99%

Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy

et al. 2017

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Purpose:In this study, we investigated whether mechanical dispersion which reflects electrical abnormality and other echocardiographic and clinic parameters predict appropriate ICD shock in patients undergone ICD implantation for hypertrophic cardiomyopathy. Methods:Sixty-three patients who received ICD implantation for primary or secondary prevention were included in the study. Patients' clinical, electrocardiographic, 2D classic, and speckle tracking echocardiographic data were collected.Mechanical dispersion was defined as the standard deviation of time to peak negative strain in 18 left ventricular segments. Appropriate ICD therapy was defined as cardioversion or defibrillation due to ventricular tachycardia or fibrillation. Patients were divided into two groups as occurrence or the absence of appropriate ICD therapy.Results: A total of 17 (26.9%) patients were observed to have an appropriate ICD therapy during follow-up periods. In patients who performed appropriate ICD therapy, a larger left atrial volume index, higher sudden cardiac death (SCD)-Risk Score, longer mechanical dispersion, and decreased global longitudinal peak strain (GLPS) were observed. In multivariate logistic regression analysis, including (GLPS, mechanical dispersion, LAVi, and SCD-Risk Score) was used to determine independent predictors of occurrence of appropriate ICD therapy during the follow-up. Mechanical dispersion, GLPS, and SCD-Risk Score were found to be independent predictors of occurrence of appropriate ICD therapy. Conclusions:Mechanical dispersion, GLPS, and SCD-Risk Score were found to be predictive for appropriate ICD therapy in patients receiving ICD implantation. Readily measurable mechanical dispersion and GLPS could be helpful to distinguish patients at high risk who could optimally benefit from ICD therapy. K E Y W O R D Selectromechanical delay, hypertrophic cardiomyopathy, myocardial strain

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Left ventricular dyssynchrony and 2D and 3D global longitudinal strain for differentiating physiological and pathological left ventricular hypertrophy

Abstract: LV dyssynchrony combined with GLS can be used to differentiate athletes with moderate LVH from patients with HCM.

Cited by 18 publications

References 25 publications

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis

Speckle tracking echocardiography in cats with preclinical hypertrophic cardiomyopathy

Mechanical dispersion and global longitudinal strain by speckle tracking echocardiography: Predictors of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy

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