Left ventricular flow propagation velocity measurement: Is it cast in stone?

Chan, Bee Ting; Yeoh, Hak Koon; Liew, Yih Miin; Aziz, Yang Faridah Abdul; Sridhar, Ganiga Srinivasaiah; Hamilton-Craig, Christian; Platts, D.; Lim, Einly

doi:10.1007/s11517-017-1639-5

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…This method substantially reduced the working time because time-consuming grid generation was necessary for only one reference time step, and it guarantees the maintenance of the connections between all grid points. The evidence for the qualitative clarification of the effects of a few simplified internal structures on the LV blood flow is that the present results for model A without internal structures show qualitative correspondence with other studies (Chan et al, 2017;Imanparast et al, 2016) regarding the occurrence of vortices in the diastolic phase and in the outflow from the aortic valve in the systolic phase (Fig. 6).…”

Section: Discussionsupporting

confidence: 89%

Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images

Yamada

Hayase

Miyauchi

et al. 2018

JBSE

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Although the blood flow velocity in a left ventricle (LV) has been considered to be sufficiently fast to prevent thrombus formation, internal wall structures, such as trabeculae carneae (TC) and papillary muscle, recently received attention as possible causes of reduced near-wall blood flow. As a fundamental consideration of this problem, this study established a method for constructing an unsteady LV model from magnetic resonance (MR) images and investigated the effect of a few simplified TC structures on the blood flow in the model. The LV model at arbitrary time steps was constructed by deforming a computational mesh generated from MR images at a reference time step. The validity of the proposed construction scheme was confirmed by comparison with the configuration of an LV model extracted from MR images. Numerical analysis was performed for the unsteady blood flow in LV models with and without two simplified TC structures. The flow field in the model with the internal structure differed from that in the model without the internal structure near the wall, and flow separation caused by the internal structure decreased wall shear stress on the rear of the internal structure. The computational results provide fundamental information for the complex interaction between the internal structures and the blood flow in an LV.

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Section: Discussionsupporting

confidence: 89%

Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images

Yamada

Hayase

Miyauchi

et al. 2018

JBSE

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show abstract

“…Chivukula et al indicated that when the inflow cannula was angled closer to alignment with the LV long axis, flow from the mitral valve to the inflow cannula was more direct [ 16 ]. However, this may not be typical for patients with dilated cardiomyopathy: the mitral jet is often directed more towards the free wall [ 24 ]. Furthermore, it was speculated that the direct flow between the mitral valve and inflow cannula inlet was favourable, contrary to the recommendations presented here.…”

Section: Discussionmentioning

confidence: 99%

Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis

Neidlin

Liao

et al. 2021

BioMed Eng OnLine

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Background Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in the implanted device orientation. A severely dilated pulsatile patient-specific left ventricle, modelled with computational fluid dynamics, was utilised to identify the risk of thrombosis for five cannulation angles. With respect to the inflow cannula axis directed towards the mitral valve, the other angles were 25° and 20° towards the septum and 20° and 30° towards the free wall. Results Inflow cannula angulation towards the free wall resulted in longer blood residence time within the ventricle, slower ventricular washout and reduced pulsatility indices along the septal wall. Based on the model, the ideal inflow cannula alignment to reduce the risk of thrombosis was angulation towards the mitral valve and up to parallel to the septum, avoiding the premature clearance of incoming blood. Conclusions This study indicates the potential effects of inflow cannulation angles and may guide optimised implantation configurations; however, the ideal approach will be influenced by other patient factors and is suspected to change over the course of support.

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Left ventricular flow propagation velocity measurement: Is it cast in stone?

Cited by 2 publications

References 36 publications

Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images

Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images

Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis

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