Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases

Araújo, Gabriela Ribeiro; Costa, Sara Ferreira dos Santos; Mesquita, Ricardo Alves; Gomez, Ricardo Santiago; Santos, Jean Nunes dos; Pontes, Hélder Antônio Rebelo; Andrade, Bruno Augusto Benevenuto De; Romañach, Mário José; Agostini, Michelle; Vargas, Pablo Agustı́n; Cáceres, Cinthia Veronica Bardález López de; Santos‐Silva, Alan Roger; Ribeiro, Ana Carolina Prado; Brandão, Thaís Bianca; Tomasi, Ramiro Alejandro; Ferreyra, R. A.; Almeida, Oslei Paes de; Fonseca, Felipe Paiva

doi:10.1007/s12105-021-01336-2

Cited by 6 publications

(26 citation statements)

References 36 publications

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“…The most frequent area is represented by the female genital tract (95%), followed by skin (3%) and gastrointestinal tract (1,5%). Even if it is a relatively common tumor, in the oral cavity, leiomyoma is encountered not that often [2,3,[5][6][7]10]. Less than 1% out of the total number of leiomyomas arise in the head and neck region, while only 0,065% occur in the oral cavity [1,4,9,11].Meanwhile, leiomyoma represents less than 1% of all tumors of the oral cavity [2].…”

Section: Discussionmentioning

confidence: 99%

“…Benign tumors of the smooth muscle are rarely present in the oral cavity and are usually nonaggressive [2,6]. "…”

Section: Discussionmentioning

confidence: 99%

“…Leiomyoma is a benign tumor of the smooth muscle, mostly found in the uterus, gastrointestinal tract, skin and subcutaneous tissues, with a rare incidence in the pathology of the oral cavity [1][2][3][4]. Oral leiomyomas present themselves as progressive, slow growing, asymptomatic masses [1][2][3]5,6], mostly found in the lingual interstitium, labial mucosa, fibromucosa of the hard palate or buccal mucosa [1,5,7].The scarcity of smooth muscle tissue in the structures of the oral cavity region, can be an explanation for the low occurrence of the leiomyomas in this anatomical region [1,6].…”

Section: Introductionmentioning

confidence: 99%

“…The certain diagnosis is determined by histological examination performed after special staining that can confirm the smooth muscle origin [5]. The treatment for this type of tumor 2 is the surgical removal [1][2][3][4][5][6][7][8][9]. When it comes to the recurrence of the tumor, it is mainly unexpected [1][2][3][4][5][7][8][9][10], however, periodical clinical monitoring is highly recommended.…”

Section: Introductionmentioning

confidence: 99%

“…The treatment for this type of tumor 2 is the surgical removal [1][2][3][4][5][6][7][8][9]. When it comes to the recurrence of the tumor, it is mainly unexpected [1][2][3][4][5][7][8][9][10], however, periodical clinical monitoring is highly recommended.…”

Section: Introductionmentioning

confidence: 99%

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Leiomyoma With Uncommon Localization – Incisive Papilla and Palatal Fibromucosa: A Case Report

Rakitovan,

Nicoara,

Closca

et al. 2023

Preprint

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The current paper presents a case of a 33-year-old female with an uncommon localization of a leiomyoma in the oral cavity - the anterior palatal fibromucosa and the incisive papilla. The patient referred to the Oro-Maxillo-Facial Surgery Clinic of the Emergency City Hospital Timisoara, Romania accusing a slight discomfort in the act of mastication and the occurrence and persistence of a diastema between the upper central incisors, due to the presence of a tumoral mass located in the anterior palatal mucosa, between the upper central incisors, without any changes of the subjacent bone structure in the anterior hard palate visible on the cone beam computed tomography image (CBCT). The tumor was removed by a surgical excisional biopsy and a histopathological examination was performed using morphological Hematoxylin–Eosin (HE) staining and additional immunohistochemical (IHC) reactions, in order to confirm the diagnosis. On microscopic examination, there were found bundles of spindle cells with eosinophilic cytoplasm and vesicular nuclei, with finely granular chromatin. The immunohistochemically staining found positive results for smooth muscle actin (SMA) and desmin and negative result for vimentin. The treatment of choice for leiomyoma of the oral cavity is surgical excision with clear margins, followed by periodical clinical monitoring.

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