Leiomyosarcoma of the Renal Vein: A Report of Two Cases

Ball, Adrian; Fisher, Carla S.

doi:10.1159/000463894

Cited by 9 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed patient and clinicopathologic characteristics are presented in Table 1 , Figure 4 and 5 . Histological biopsy before treatment was performed in 9 patients (13.4%; 9/67); 1 patient had biopsy during exploration 9 , 4 patients had CT guided CNB 19 , 20 , 27 , 50 , the biopsy type for 2 patients was not specified in the article 33 , 41 and 2 patients had biopsy through femoral approach during cavography. 36 , 43 FNAB before operation was performed in 1 patient 34 and in our case (3.0%; 22/67).…”

Section: Resultsmentioning

confidence: 99%

“…Four patients were excluded for the survival analysis, because 3 were disseminated at the time of diagnosis 19 , 20 , 26 and one was not treated surgically. 36 Two patients were alive with disease and on palliative care at the time of report.…”

Section: Resultsmentioning

confidence: 99%

“… 50 In some articles more than one case was reported. 14 , 19 , 26 , 42 , 46 The authors were from the fields of urology (18/49; 36.7%), surgery (15/49; 30.6%), radiology (8/49; 16.3%), pathology (5/49; 10.2%) and internal medicine (3/49; 6.1%). A retrospective review was performed to evaluate patient demographics, tumour site, clinical presentation, operative details, tumour thrombus IVC extension, neoadjuvant and adjuvant treatment, tumour size, tumour grade, surgical margin status, time to local recurrence, time to dissemination, time to death and status at last follow up.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Leiomyosarcoma of the renal vein: analysis of outcome and prognostic factors in the world case series of 67 patients

Novak

Perhavec

Maturen

et al. 2016

Radiology and Oncology

View full text Add to dashboard Cite

BackgroundLeiomyosarcoma is a rare malignant mesenchymal tumour. Some cases of leiomyosarcoma of the renal vein (LRV) have been reported in the literature, but no analysis of data and search for prognostic factors have been done so far. The aim of this review was to describe the LRV, to analyse overall survival (OS), local recurrence free survival (LRFS) and distant metastases free survival (DMFS) in LRV world case series and to identify significant predictors of OS, LRFS and DMFS.MethodsCases from the literature based on PubMed search and a case from our institution were included.ResultsSixty-seven patients with a mean age of 56.6 years were identified; 76.1% were women. Mean tumour size was 8.9 cm; in 68.7% located on the left side. Tumour thrombus extended into the inferior vena cava lumen in 13.4%. All patients but one underwent surgery (98.5%). After a median follow up of 24 months, the OS was 79.5%. LRFS was 83.5% after a median follow up of 21.5 months and DMFS was 76.1% after a median follow up of 22 months. Factors predictive of OS in univariate analysis were surgical margins, while factors predictive of LRFS were inferior vena cava luminal extension and grade. No factors predictive of DMFS were identified. In multivariate analysis none of the factors were predictive of OS, LRFS and DMFS.ConclusionsBased on the literature review and presented case some conclusions can be made. LRV is usually located in the hilum of the kidney. It should be considered in differential diagnosis of renal and retroperitoneal masses, particularly in women over the age 40, on the left side and in the absence of haematuria. Core needle biopsy should be performed. Patients should be managed by sarcoma multidisciplinary team. LRV should be surgically removed, with negative margins.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Leiomyosarcoma of the renal vein: analysis of outcome and prognostic factors in the world case series of 67 patients

Novak

Perhavec

Maturen

et al. 2016

Radiology and Oncology

View full text Add to dashboard Cite

show abstract

“…Ultrastructural and immunohistochemical studies have been helpful in determining tumor origin. Leiomyosarcomas uniformly stain positive for desrnin, and occasionally stain positive for smooth muscle actin or vimentin, indicating a smooth muscle cell origin [ 14,15,[19][20][21]23,24]. Fibrosarcomas are usually vimentin positive and desmin negative, with sharp nuclei and abundant collagen fibers.…”

Section: Casementioning

confidence: 99%

Leiomyosarcoma of the renal vein

et al. 1996

View full text Add to dashboard Cite

The preoperative diagnosis for primary leiomyosarcoma of the renal vein, an extremely rare tumor, is difficult. The tumor predominantly occurs in women and on the left side. Its natural history is toward distant metastases and a poor 5‐year survival rate. Nephrectomy and en‐bloc surgical resection remain the mainstay of therapy. We present three such cases and review the world literature. © 1996 Wiley‐Liss, Inc.

show abstract

Venous invasion in renal vein leiomyosarcoma: case report and review of the literature

et al. 1995

View full text Add to dashboard Cite

Tumors arising from veins are rare, usually present with nonspecific clinical and imaging findings and almost universally show histology of leiomyosarcoma. This twentieth reported case of primary renal vein leiomyosarcoma demonstrates invasion of the renal vein with endoluminal propagation of tumor into the infrahepatic inferior vena cava (IVC), an unreported manifestation. The combination of CT, ultrasound, and angiographic studies allowed differentiation from renal cell carcinoma by suggesting a tumor arising from the renal vein.

show abstract

Leiomyosarcoma of the Renal Vein: A Report of Two Cases

Cited by 9 publications

References 3 publications

Leiomyosarcoma of the renal vein: analysis of outcome and prognostic factors in the world case series of 67 patients

Leiomyosarcoma of the renal vein: analysis of outcome and prognostic factors in the world case series of 67 patients

Leiomyosarcoma of the renal vein

Venous invasion in renal vein leiomyosarcoma: case report and review of the literature

Contact Info

Product

Resources

About