Leishmaniasis Affecting the Eyelids

Chu, Fred C.; Rodrigues, Merlyn M.; Cogan, David G.; Neva, Franklin A.

doi:10.1001/archopht.1983.01040010086015

Cited by 25 publications

(15 citation statements)

References 21 publications

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“…However, the appearance of the biopsy on histopathologic examination was not typical of Chagas disease, and the isolation of Leishmania m. mexicana from the lesion confirmed the diagnosis. Leishmaniasis affecting the eyelid has previously been reported in both Old World and New World cutaneous leishmaniasis, having been associated with L. (Vianna) braziliensis and L. major, but without culture confirmation [14][15][16][17].…”

Section: Discussionsupporting

confidence: 41%

Leishmania mexicana infection of the eyelid in a traveler to Belize

Vinetz¹,

Soong²

2007

Braz J Infect Dis

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A 50 year-old man, a United States resident, presented in Texas with a violaceous non-ulcerating lesion, involving the entire lower eyelid. The patient had traveled to a jungle area of Belize several hours drive from the capital city. Leishmania mexicana was isolated. The lesion only partially resolved after an initial course of sodium stibogluconate, requiring retreatment. At two years of follow-up, there was no relapse. The parasite isolated from the patient caused a progressive, non-ulcerating lesion in an experimental mouse footpad infection. This is an unusual case of cutaneous leishmaniasis in a traveler. Travelers must be educated about personal protective measures to prevent exotic infections acquired during travel.

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Section: Discussionsupporting

confidence: 41%

Leishmania mexicana infection of the eyelid in a traveler to Belize

Vinetz¹,

Soong²

2007

Braz J Infect Dis

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“…27,28 In immunocompetent humans with ocular manifestations of leishmaniasis, there is generally a good prognosis for improvement following antiprotozoal therapy. 23,29,30 In summary, ocular manifestations are a common manifestation of canine leishmaniasis, occurring in approximately 25% of cases. Anterior uveitis is the most common finding and may have an immunologic basis.…”

Section: Discussionmentioning

confidence: 99%

Ocular and periocular manifestations of leishmaniasis in dogs: 105 cases (1993–1998)

Peña

Roura

Davidson

2000

Veterinary Ophthalmology

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The purpose of this retrospective study was to determine the prevalence, type, and prognosis of ocular lesions associated with leishmaniasis in dogs. One hundred and five dogs (24.4% of all cases of leishmaniasis diagnosed during the study period) had ocular or periocular leishmaniasis, and 16 dogs (15.2% of ocular cases) had only ocular lesions and systemic signs were not apparent. Anterior uveitis was the most common manifestation and other prevalent findings included blepharitis and keratoconjunctivitis. Several distinct variations of eyelid lesions were seen including a dry dermatitis with alopecia, diffuse blepharedema, cutaneous ulceration, and discrete nodular granuloma formation. In some cases with keratoconjunctivitis, corneal lesions clinically resembled nodular granulomatous episclerokeratitis. Twenty-seven of the 34 cases with ocular lesions had improvement in signs following systemic antiprotozoal and topical anti-inflammatory therapy, although many cases with anterior uveitis required long-term topical therapy. Response of ocular signs correlated highly with overall, systemic response to therapy. Ophthalmic manifestations of systemic leishmaniasis are common in the dog, and this disease should be considered in the differential diagnosis of most adnexal and anterior segment ocular inflammatory lesions in dogs in endemic areas.

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“…Some authors have advanced the interesting hypothesis that eyelid movements prevent sandfly bites. 12,25 Ocular leishmaniasis occurs especially on the eyelids, 2,5,6,10,12,15,19,[21][22][23][24][25][26][27]29 where it presents as highly polymorphous lesions, such as swelling, 2,27 papules, 28 plaques, 28 nodules (sometimes ulcerative or covered by crusts and scaling), 2,26,28 erosions, 23 and ulcers. 10,23 Because of these clinical presentations, the differential diagnosis of eyelid leishmaniasis includes a number of different diseases, such as cysts, 6 chalazia, 22,23,25 basal cell carcinoma, 23,26 tuberculosis, 23 syphilis, 23 and sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Leishmaniasis of the eyelid mimicking an infundibular cyst and review of the literature on ocular leishmaniasis

Veraldi

Bottini

Currò

et al. 2010

International Journal of Infectious Diseases

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Cutaneous leishmaniasis is an infection caused by protozoa belonging to the genus Leishmania. The disease is transmitted by sandflies. Reservoirs are represented by dogs, mice, rats, and wild rodents. Cutaneous leishmaniasis is usually characterized by a single, polymorphous lesion located in an uncovered area. We report a case of cutaneous leishmaniasis localized on the left upper eyelid in a 36-year-old woman. The disease was characterized by a single, asymptomatic nodule, which was clinically diagnosed as an inflammatory infundibular cyst. The lesion was excised surgically. Histopathological examination showed an inflammatory infiltrate consisting of lymphocytes, histiocytes, and plasma cells. Several Leishmania spp amastigotes were observed in the cytoplasm of macrophages. Culture examination on Novy-MacNeal-Nicolle medium was positive for Leishmania spp. PCR was positive for Leishmania infantum. No relapses were observed during follow-up (17 months). The purpose of this report is to emphasize the changeability of clinical presentation in cutaneous leishmaniasis.

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Leishmaniasis Affecting the Eyelids

Cited by 25 publications

References 21 publications

Leishmania mexicana infection of the eyelid in a traveler to Belize

Leishmania mexicana infection of the eyelid in a traveler to Belize

Ocular and periocular manifestations of leishmaniasis in dogs: 105 cases (1993–1998)

Leishmaniasis of the eyelid mimicking an infundibular cyst and review of the literature on ocular leishmaniasis

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