Leitlinien für Diagnostik und Therapie in der Neurologie

Abstract

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Real life pharmaceutical treatment patterns for adult patients with focal epilepsy in Germany: a longitudinal and cross-sectional analysis of recently approved anti-epileptic drugs

“…The generally lower percentage of the no-AED therapy group in comparison to the study by Ertl et al [32] can potentially be explained by our conservative sample definition which required at least one AED prescription in the whole observation period. Without knowledge about disease specifics of these patients, the pattern of the steadily increasing percentage of patients with no AED therapy may be explained by several factors: Firstly, epilepsy surgery or treatment with vagus nerve stimulation (VNS) are therapy options for drug-resistant epilepsy patients [33], [34]. Patients with a successful surgery may not need any subsequent AED therapy.…”

“…Patients with a successful surgery may not need any subsequent AED therapy. Secondly, AED withdrawal may be an option for patients who have been seizure free for several years [33], [35]. Thirdly, non-persistence in AED treatment may also explain why a certain percentage of patients did not receive any AED therapy in the observed follow-up years [36], [37].…”

“…The data suggest that even if most of these drugs have been available for several years by the time of the observation, a small proportion (<6%) of all adult FE patients received a novel AED therapy. In line with both the label of those drugs and the recommendations of the German Society for Epileptology (Deutsche Gesellschaft für Epileptologie, DGfE), patients received novel AEDs in addition to other AEDs [23], [24], [26], [33], [38]. Furthermore, they received at least 2–3 other AEDs before a novel AED therapy was started.…”

Lumbalpunktion bei Kindern – Schritt für Schritt

“…7). Ein Liquoreröffnungsdruck > 25 cm H 2 O gilt nach der Leitlinie der DGN als pathologisch [1,3]. Nach neueren Untersuchungen ist bei adipösen Kindern erst ein Liquordruck ab > 28 cm H 2 O als sicher pathologisch zu werten [4,5,7].…”

“…Häufige, seltene und sehr seltene Nebenwirkungen der Liquorpunktion auf Basis der Leitlinie "Diagnostische Liquorpunktion" der DGN[1].Zur Lokalanästhesie sollte an der Punktionsstelle (30-)60 Minuten vor dem Eingriff ein Lidocain-und Prilocain-Pflaster (z. B. EMLA ® ) geklebt werden.…”