Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains

Ogasawara, Michihiro; Imanishi, Tadashi; Moriwaki, Kazuo; Gaudieri, Silvana; Tsuda, Hiroshi; Hashimoto, Hiroshi; Shiroishi, Toshihiko; Gojobori, Takashi; Koide, Tsuyoshi

doi:10.1016/j.gene.2004.11.050

Cited by 16 publications

(24 citation statements)

References 36 publications

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“…In the analyses of complex traits in wild-derived strains, we identified a marked diversity of phenotypes among strains [12,17,24,29]. The phenotypic diversity is believed to be a result of genetic diversity among wild-derived strains, as shown by several studies on genomic polymorphisms of these strains [17,18,20,23,27]. As each wild-derived strain has a different evolutionary history, we can expect a unique haplotype in each strain [16].…”

Section: Proposal Of a New Approach To Elucidate Complex Traitsmentioning

confidence: 95%

Genomic Mixing to Elucidate the Genetic System of Complex Traits

2012

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Abstract:Understanding the genetic basis of complex traits has become one of the major issues in genetics, but recent advances in this field are still faced with a difficulty, the so-called "missing heritability." It is speculated that missing heritability mainly stems from a large number of variants of small effect that are poorly detected by currently available methods. In order to overcome this problem, many recent genetic studies of complex traits have actively used outbred stocks of mice. However, most of the available outbred stocks have a limited amount of genetic variation, because many stocks originate from Swiss mouse colonies. We have repeatedly shown that wild-derived strains are a useful mouse resource since there is a large genetic diversity among these strains. Here, we give an overview of mouse resources produced by crossing different founder mice. Finally, we propose an advantage of new attempts to conduct selective breeding using heterogeneous stocks created by mixing genomes of wild-derived inbred strains of mice when studying complex traits.

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Section: Proposal Of a New Approach To Elucidate Complex Traitsmentioning

confidence: 95%

Genomic Mixing to Elucidate the Genetic System of Complex Traits

2012

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“…The Mus musculus species is divided into at least three major subspecies groups, Domesticus, Musculus, and Castaneus, based on the genetic profiles, such as polymorphisms of biochemical markers, mtDNA, and nuclear genes (Fig. 1) [2,17,21,23]. Although, further taxonomic subdivisions have been applied based on their geographical distribution and morphological characteristics, these local subspecies have been classed as heterogeneous with the major subspecies groups because clear genetic differences have not been identified among these subdivided taxonomic subspecies.…”

Section: Wild Mice and Wild Strainsmentioning

confidence: 99%

“…Several studies characterizing polymorphisms in genomic sequences have been carried out to clarify the genetic profi les of these wild-derived strains [14,16,21]. Polymorphisms in repeat numbers of CA dinucleotides in microsatellite marker polymorphisms were studied by simple-sequence length polymorphism (SSLP) analysis using the agarose-gel electrophoresis method employing genomic DNA of these wild-derived strains [14].…”

Section: Genetic Profi Les Of Wild and Laboratory Strainsmentioning

confidence: 99%

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A New Twist on Behavioral Genetics by Incorporating Wild-Derived Mouse Strains

Koide

Ikeda

Ogasawara³

et al. 2011

Exp. Anim.

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Abstract:Behavior has been proven to be extremely variable among human individuals. One of the most important factors for such variations of behavior is genetic diversity. A variety of mouse strains are reportedly suitable animal models for investigating the genetic basis of large individual differences in behavior. Laboratory strains have been shown to exhibit different behavioral traits due to variations in their genetic background. However, they show low-level genetic polymorphism because the original colony used for establishing the strains comprises a relatively small number of mice. Furthermore, because the laboratory strains were derived from fancy mice, they have lost the original behavioral phenotype of wild mice. Therefore, incorporation of inbred strains derived from wild mice of different mouse subspecies for behavioral studies is a marked advantage. In the long-term process of establishing a variety of wild-derived inbred strains from wild mice captured all over the world, a number of strains have been established. We previously identified a marked variety in behavioral traits using a Mishima battery. This review reports on the usefulness of wild-derived strains for genetic analyses of behavioral phenotypes in mice.

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“…The CAG repeat regions in the mouse GR gene have been previously described (8). Xu et al (9) have reported that the polymorphic form of mouse GR plays a critical role in complex mechanisms leading to corticosterone responses and anxiety-type behavior to restraint stress.…”

Section: Introductionmentioning

confidence: 99%