Lens Epithelial Cell Proliferation

An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens

“…Postnatally, lens growth is dependent on the proliferation of the epithelial cells in the germinative zone, and their subsequent differentiation into fiber cells at the transitional zone. 2 , 3 Fiber differentiation is characterized by distinct molecular and morphologic changes, such as exit from the cell cycle, cell elongation, loss of cytoplasmic organelles, and nuclei, as well as the accumulation of fiber-specific crystallin proteins. 4 The normal architecture, and hence transparency of the lens, depends on the maintenance of this distinctive pattern of growth.…”

Expression and function of PDGF-α in columnar epithelial cells of age-related cataracts patients

“…It further promotes cell proliferation and migration activities. In the absence of trauma or external stimuli, such unregulated proliferation and migration has no benefit for the lens, whereas it may destroy the normal structure of the local columnar epithelium (Lovicu et al, 2014). Furthermore, the cells presented fibrosis characteristics after PDGF-α stimulus, which had various effects as the lens epithelial cells gradually decreased.…”