Lentigo Maligna: Keys to Dermoscopic Diagnosis

Bollea-Garlatti, L.A.; Galimberti, Gastón; Galimberti, Ricardo

doi:10.1016/j.adengl.2016.05.017

Cited by 8 publications

(16 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…imaging techniques that can help the clinical diagnosis of this tumour. [1][2][3][4][5][6][7][8][9][10] However, there is no study that compares these techniques used alone to their combination for LM/LMM, and there are only two studies that directly compared their diagnostic accuracy for LM/LMM. 8,9 The largest study was performed by our group on 223 facial lesions with histological diagnosis and compared dermoscopy to RCM alone, 9 whereas the other compared dermoscopy plus digital dermoscopic monitoring to RCM in 70 lesions (33 with histological diagnosis).…”

mentioning

confidence: 99%

The integration of dermoscopy and reflectance confocal microscopy improves the diagnosis of lentigo maligna

Cinotti

Fiorani

Labeille

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

mentioning

confidence: 99%

The integration of dermoscopy and reflectance confocal microscopy improves the diagnosis of lentigo maligna

Cinotti

Fiorani

Labeille

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

“…3 Etanercept shows considerably less transport than other anti-TNFa because of its different size and its shorter half-life. 4 Infliximab and adalimumab may preferentially be stopped before 20 weeks and etanercept before weeks 30-32 of pregnancy. 5 Certolizumab pegol is an IgG1 antibody without Fc portion, and it does not cross the placental barrier nor the breast milk.…”

Section: Tablementioning

confidence: 99%

“…[1][2][3] However, the scientific evidence of this recommendation is only based on experts' opinions. 4 Only a previous article tried to evaluate the importance of this indication. 5 To evaluate the influence of patch testing in the management of our patients with therapy-resistant AD, we conducted a retrospective analysis of 37 patients with therapy-resistant AD patch tested between June 2007 and June 2017.…”

Section: Tablementioning

confidence: 99%

“…Patch testing was indicated in patients with widespread AD before initiating long-term systemic immunosuppressant therapy and patients who did not improve or immediately rebounded upon discontinuation of topical therapy. 1,4 All patients were patch tested with the Spanish baseline series, 6 TRUE Test â . When indicated, complementary series were used.…”

Section: Tablementioning

confidence: 99%

See 1 more Smart Citation

Psoriasis and pregnancy outcomes in biological therapies: a real‐life, multi‐centre experience

Odorici

Lernia

Bardazzi

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

four of them) or by RCM alone (evaluation performed by six of them) 1 year before and results were compared with the previous study. Mean sensitivity, specificity and overall diagnostic accuracy (ACC) and 95% CI were calculated for the specific diagnosis of different facial lesions (Table 1). As expected, considering the evaluation of the seven experts, the combination dermoscopy/RCM had a higher mean ACC for both malignant tumour (including LM/LMM) and LM/LMM of the face (84%, CI 80-89 and 84%, CI 79-89, respectively) than the two imaging techniques alone (74%, CI 68-80 for dermoscopy vs. 80%, CI 75-85 for RCM in case of LM/LMM and 75%, CI 68-80 for dermoscopy vs. 80%, CI 74-85 for RCM in case of malignant tumour). Notably, ACC increased for each investigator. The superiority of the ACC of the combination dermoscopy/RCM on the single imaging techniques for LM/LMM was also observed when comparing the current data to the results obtained in the previous study by all the 21 investigators. Considering all evaluations, the ACC increased from dermoscopy to RCM and to dermoscopy plus RCM. According to the CI, the combination dermoscopy/RCM improved both mean sensitivity and mean specificity of RCM alone for LM/LMM, whereas it highly improved mean sensitivity of dermoscopy alone but not its mean specificity (sensitivity of 65% CI 57-73, 82% CI 76-89 and 85% CI 80-91 and specificity of 88% CI 82-95, 77% CI 68-86 and 83% CI 75-91 for dermoscopy, RCM, and dermoscopy plus RCM, respectively). As already discussed, this fact was probably related to the presence of hyper-reflective dendritic Langerhans cells under RCM mistaken for neoplastic melanocytes in the epidermis of most misdiagnosed benign lesions. 9 Concerning the facial lesions other than LM/LMM, we also observed an increase in ACC with the combination dermoscopy/RCM (Table 1). In conclusion, this study shows that the integration of dermoscopy and RCM increases the ACC of both these techniques used alone for facial tumours. More in-depth studies should be carried out, even using machine learning techniques, for optimal integration of dermoscopic data with RCM data, in order to increase ACC by reducing possible false positives induced by the RCM examination. This study received the approval from the Ethical Committee of the University Hospital of Saint-Etienne (Institutional review board number 672016/CHUSTE).

show abstract

“…Lentigo maligna and lentigo maligna melanoma also enter into the differential diagnosis of nevus of Ota. Obliterated hair follicles, asymmetric pigmented follicular openings and pigmented rhomboidal structures are the strong dermoscopic clues to lentigo maligna and lentigo maligna melanoma (5,6). The histopathological differential diagnosis of the nevus of Ota includes Mongolian spots and nevus of Ito which are the other main types of patchy dermal melanocytosis.…”

mentioning

confidence: 99%

Dermoscopic Findings of Nevus of Ota

Elmas¹,

Kilitçi²

2020

Balkan Med J

View full text Add to dashboard Cite

To the Editor, Nevus of Ota, also known as oculodermal melanocytosis, is characterized by a macular pigmentation usually localized on the forehead and periocular region. It typically shows a dermatomal distribution and the dermatomes of the first two branches of trigeminal nerve are typically involved (1,2). The diagnosis is usually based on the clinical appearance. In some cases, however, histopathological examination may be necessary. Dermoscopy is a non-invasive diagnostic tool enhancing the diagnostic accuracy in many dermatological diseases including both pigmented and non-pigmented ones. There is a comprehensive literature about the dermoscopic characteristics of many pigmented lesions, however, no data regarding the dermoscopic features of nevus of Ota exists in the relevant literature except for a single case report (3). Herein, we aimed to describe dermoscopic features of the lesions having a clinicopathological diagnosis of nevus of Ota. Dermoscopic examination was performed by a polarized handheld dermoscope with x10 magnification (Dermlite 4, 3GEN Inc, San Juan Capistrano, CA, USA). The dermoscopic images were captured using a high-resolution mobile camera phone attached to the dermoscope (iPhone 7 plus, Apple Inc, CA, USA). A total of 10 patients including 6 males and 4 females diagnosed with the nevus of Ota was enrolled. A written informed consent was obtained from all the participants. The mean age of the patients was 32 years (range 17-62). All of the lesions showed unilateral distribution. The most common localization was forehead (Figure 1a) followed by periorbital region. Scleral involvement was observed in 4 cases. All of the patients were consulted to the ophthalmologist and, none of the patients showed glaucoma or uveal melanoma. The most common dermoscopic findings were brown and gray structureless areas with a patchy distribution (Figure 1b, 1c) and scattered browngray dots (Figure 1b, 1c, 1d) which were observed in all of the lesions. Eight lesions showed terminal hairs (Figure 1d), and the fine scales were observed in 2 lesions. 4 lesions exhibited white clods in a "four dots clod" arrangement (Figure 1b, 1d). Perifollicular hypopigmentation was seen in 6 lesions (Figure 1d). Two lesions revealed yellowish structureless areas.

show abstract

Lentigo Maligna: Keys to Dermoscopic Diagnosis

Cited by 8 publications

References 23 publications

The integration of dermoscopy and reflectance confocal microscopy improves the diagnosis of lentigo maligna

The integration of dermoscopy and reflectance confocal microscopy improves the diagnosis of lentigo maligna

Psoriasis and pregnancy outcomes in biological therapies: a real‐life, multi‐centre experience

Dermoscopic Findings of Nevus of Ota

Contact Info

Product

Resources

About