IntroductionsBreast cancer is the most common type of cancer in women and the risk increases with age. As in other tumors the development of breast carcinoma is associated with systemic inflammation. The systemic inflammatory response can change with tumor growth, invasion, angiogenesis and metastasis. İnflammatory markers such as c reactive protein (CRP) and interleukin 6 (IL 6) are increased in breast cancer patients and a have adverse effect on survey (Balta et al., 2013).Benign proliferative breast disease (BPBD) is most common in women who are in their thirties to fifties. Various sizes of cysts, adenosis, hyperplasia with atypia and/or without atypia and apocrine metaplasia can be seen in BPBD on microscopic examination. Despite the strong association between BPBD and breast cancer development, the exact causes of BPBD are still unknown. Hormonal imbalance especially increased estrogen via to progestin is thought to play a role in development of BPBD. Breast cancer risk related with proliferative breast disease. Several studies showed that inflammation plays an important role in the development of BPBD and early breast carcinogenesis (Catsburg et al., 2014).Complete blood count and its subtype neutrophil count and neutrophil lymphocyte ratio (NLR) are an indicator of systemic inflammation (Guthrie et al., 2013). AbstractBackground: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancer patients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. Materials and Methods: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). Results: NLR values were significantly higher in the PBC patients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBC patients. Conclusions: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.

Key Clinical MessageWe report a case of hemosiderotic dermatofibroma presenting as a brown‐black‐colored nodule with peripheral extensions, which mimics melanoma. Histopathology showed completely benign features with no atypia or mitosis. Nodular extensions of childhood dermatofibromas may be related to the growth of the child not necessarily pointing to a malignant process.

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Aim:Dermoscopic features of cutaneous squamous cell carcinoma (SCC) have been well described; however, there are a few studies focused on the dermoscopic aspect of lip SCC. In this study, we aimed to identify dermoscopic findings of lower lip SCC.Materials and Methods:The clinical and histopathologic features, dermoscopic images, and demographic data of the patients with histologically approved lip SCC were retrospectively evaluated.Results:A total of 10 lesions were enrolled in the study. Milky red structureless background (100%) and keratin scale (100%) were present in all the lesions. Blood spots on thick keratin scale were observed in eight lesions. Seven lesions showed white structureless areas. Two lesions exhibited ulceration and one of the lesions had structureless brown pigmentation. The most common vascular pattern observed was polymorphous vascular pattern (60%).Conclusion:White and milky red structureless areas, blood spots on thick keratin scale, and polymorphous vascular pattern are the main dermoscopic clues to lip SCC. The presence of these findings should direct the clinician to the possibility of SCC. The dermoscopic findings observed may also reflect histological grade of the lesion.

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