Leontopodic acid—a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties

Schwaiger, Stefan; Cervellati, Rinaldo; Seger, Christoph; Ellmerer, Ernst P.; About, Nancy; Renimel, Isabelle; Godenir, Celine; André, Patrice; Gafner, Frank; Stuppner, Hermann

doi:10.1016/j.tet.2005.03.002

Cited by 51 publications

(43 citation statements)

References 26 publications

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“…The presence of this rare type of compounds was not reported in Inula sp. before, although the presence of di-tri-and tetracaffeoylglucaric acid derivatives was demonstrated in other genera of Asteroideae subfamily such as Leontopodium, Gnaphalium and Eupatorium (Schwaiger et al 2005;Maas et al 2009;Cicek et al 2012). Jaiswal et al (2011) identified six hydroxycinnamic acid derivatives in the extract from aerial parts of I. helenium, including three monocaffeoylquinic acids (1-O-, 3-O-, and 5-O-CQA), 5-O-feruloylquinic acid, 5-O-p-coumaroylquinic acid, and 3-Ocaffeoyl-4-O-p-coumaroylquinic acid.…”

Section: Resultsmentioning

confidence: 93%

Hydroxycinnamates from elecampane (Inula helenium L.) callus culture

2016

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Hydroalcoholic extract from Inula helenium callus tissue showed remarkable reducing capacity. An HPLC/DAD analysis revealed the presence of numerous hydroxycinnamic acid derivatives, including chlorogenic acid (5-O-CQA, 0.1 % dry weight) and 3,5-dicaffeoylquinic acid (3,5-DCQA, 0.3 % dry weight), which were among major constituents of the examined extract. Application of a hyphenated chromatographic method-UHPLC/DAD/MS n -allowed identification of sixteen compounds, derivatives of caffeic acid. Apart from the compounds commonly found in Inula sp., the plant material contained eight conjugates of caffeic acid with aldaric acid. The aldarates constituted over 50 % of the hydroxycinnamate fraction in the examined tissue. This is the first report on the occurrence of the caffeoylaldaric acids in Inula sp. and in a plant tissue culture.

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Section: Resultsmentioning

confidence: 93%

Hydroxycinnamates from elecampane (Inula helenium L.) callus culture

2016

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“…value of a methanol extract from Wulfenia carinthiaca Jacq., that is (0.15 ð 0.01) μg/ml resorcinol (Re) equivalents: it must be taken into account that the W. carinthiaca extract contains the very powerful antioxidants phenylpropanoid glycosides (Cervellati et al, 2004b). Chlorogenic acid is a well-known antioxidant with DNA-protecting properties (Schweiger et al, 2005); its r.a.c. value is indeed high.…”

Section: Resultsmentioning

confidence: 99%

Deoxypodophyllotoxin Content and Antioxidant Activity of Aerial Parts of Anthriscus sylvestris Hoffm.

Dall’Acqua

Giorgetti²,

Cervellati³

et al. 2006

Zeitschrift Für Naturforschung C

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Deoxypodophyllotoxin content of the aerial parts of Anthriscus sylvestris Hoffm. growing at different altitudes was evaluated in comparison to the roots. The lignan accumulation in ground parts was at least double compared to aerial ones.In addition antioxidant-guided fractionation of the crude methanol extract of aerial parts was performed with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. Active fractions contained mainly luteolin-7-O-glucoside and chlorogenic acid. Antioxidant properties of both crude extract and isolated compounds were also investigated with the Briggs-Rauscher (BR) oscillating reaction. A satisfactory agreement between the results obtained with the two methods was observed.

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“…In addition to the outstanding antiinflammatory, antibacterial (Dobner et al 2004) -even with infections (Stuppner, 2000) -and analgesic effects (Speroni et al, 2006) the "Edelweiss" shows a superior property as a scavenger and antioxidant (Schwalger et al, 2005) and preserves so cells from damage (also by molds; (Costa et al, 2009). While Leoligin (Fig.…”

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confidence: 99%

VITA Intense – Product with Negative Oxidation-reduction Potential (ORP) as Important Quality for Antioxidant and Inhibition Growth of Tumor Cells Effects. Anti Aging Effects

Ignatov¹,

Pesheva²

2018

European Journal of Medicine

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We studied the mathematical model of interaction with water VITA intense of LavaVitae company (Austria). In this report are submitted data about the interaction of VITA intense with water, obtained by non-equilibrium (NES) and differential-equilibrium energy spectrum (DNES) of water. The average energy (∆EH... O) of hydrogen Н…O-bonds among individual molecules H2O after treatment of VITA intense with water measured by NES-and DNES-methods is ∆E=-0.0136±0.0011 eV for VITA intense. This result suggests the restructuring of ∆EH... O values among H2O molecules with a statistically reliable increase of local extremums in DNES-spectra. The research is performed for VITA intense, with study of pH and oxidative reduction potential (ORP). There is review of the effects of the chemical composition of VITA intense -antiinflammatory, antioxidant etc. With methods NES we show the following effects -relaxing effect of nervous system, anti-inflammatory and inhibition of tumor cells. As results of these effects VITA intense has anti aging influence. The base of this influence is anti-inflammatory effect. This article deals with the review of the basic biophysical-biochemical and biological processes underlying the VITA intense. The author is studying their physical-chemical properties and biophysical and biological effects on human organism. Additionally, by using IR, NES, and DNES methods are investigated various samples of water from Bulgarian water springs: the melt water from Glacier Rosenlaui, Swiss Alps, as well as the human blood serum of people with excellent health and cancer patients between 50 and 70 years old. Other experiments were performed on a 1 % (v/v) solution of VITA intense in deionized water. As an estimation factor in NES and DNES was measured the values of the average energy of hydrogen bonds (∆EH...O) among H2O molecules in water samples, as well as a local extremums in the NES and DNES-spectra of various samples of water and the human blood serum at E = -0.1387 eV and λ = 8.95 μm. For a group of people in critical condition of life and patients with malignant tumors the greatest values of local extremums in IR-, DNESspectra were shifted to lower energies relative to the control healthy group. Further we applied this method for calculation of percent distribution of H2O molecules in all studied water samples according to energies of hydrogen bonds ranged from (-0.08 to -0.1387 eV). It was shown that mountain water is among the most important factors for human longevity and human health. The variety of ions (K + , Na + , Ca 2+ , Mg 2+ , Mn 2+ , Fe 2+ , Fe 3+ , Zn 2+ , SO4 2-, Cl -, HCO3 -, CO3 2-), the chemical-physical parameters (pH, electroconductivity) and the decreased content of deuterium in studied water samples renders beneficial effects of these types of water on human health. We are applying the conclusions for the effects of mountain water on human health and longevity as base * Corresponding author E-mail addresses: mbioph@abv.bg (I. Ignatov) European Journal of Medicine, 2018, 6(1) ...

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Leontopodic acid—a novel highly substituted glucaric acid derivative from Edelweiss (Leontopodium alpinum Cass.) and its antioxidative and DNA protecting properties

Cited by 51 publications

References 26 publications

Hydroxycinnamates from elecampane (Inula helenium L.) callus culture

Hydroxycinnamates from elecampane (Inula helenium L.) callus culture

Deoxypodophyllotoxin Content and Antioxidant Activity of Aerial Parts of Anthriscus sylvestris Hoffm.

VITA Intense – Product with Negative Oxidation-reduction Potential (ORP) as Important Quality for Antioxidant and Inhibition Growth of Tumor Cells Effects. Anti Aging Effects

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