Lepiginosides A-D: three new triterpenoid saponins and a new farnesyl glycoside from the stembarks of Lepisanthes rubiginosa (roxb.) leenh

Abstract

Phytochemical investigation of methanolic extract of L. rubiginosa using modern chromatographic techniques has led to the isolation of three new triterpenoid saponins, lepiginosides A-C (1-3), a new farnesyl glycoside, lepiginoside D (4), together with lepisantheside B (5) and gleditsoside C (6). The characterization and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. Moreover, the antibacterial activity against seven bacteria, but none is active.

Saponins of Selected Triterpenoids as Potential Therapeutic Agents: A Review

“…Three new oleanane-type triterpenoid saponins ( 7a – 7c ; Figure 7 ) were isolated and identified in the extracts from the stem bark of mertajam, Lepisanthes rubiginosa Roxb. (Sapindaceae), a plant growing in Asia, namely in Malaysia, Thailand, and Vietnam, and in the tropical areas of Africa and north-western Australia [ 47 ]. The plant has been extensively used in traditional medicine, namely to treat fever, headache, cough, diarrhea, dysentery, and jaundice [ 48 ].…”

“…Finally, an intensive investigation resulted in the isolation of several new triterpenoid glycosides, lepiginosides ( 7a – 7c ) [ 48 ]. The potential antibacterial activity of the isolated compounds was tested in Klebsiella pneumoniae , Pseudomonas aeruginosa , Salmonella typhimurium , Shigella sonnei , Escherichia coli , Staphylococcus haemolyticus , and in the methicillin-resistant Staphylococcus aureus ; however, none of the investigated triterpenoid saponins showed significant activity [ 47 ]. Therefore, it seems reasonable that a synergic action of different constituents in the extracts of L. rubiginosa is required for the pharmacological effects to be displayed, as it was found for the plant extracts.…”