2014
DOI: 10.1590/abd1806-4841.20142460
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Leprosy: a review of laboratory and therapeutic aspects - Part 2

Abstract: Leprosy is a chronic infectious condition caused by Mycobacterium leprae(M. leprae). It is endemic in many regions of the world and a public health problem in Brazil. Additionally, it presents a wide spectrum of clinical manifestations, which are dependent on the interaction between M. leprae and host, and are related to the degree of immunity to the bacillus. The diagnosis of this disease is a clinical one. However, in some situations laboratory exams are necessary to confirm the diagnosis of leprosy or class… Show more

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Cited by 53 publications
(42 citation statements)
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“…protein. 4 However, this serological test often gives falsenegative results due to a low number of bacilli or low antibody levels. 4 The sensitivity of the serological test on PB-type leprosy ranges only between 15% and 40%.5 Therefore, serological testing is not recommended for diagnosing PB-type leprosy due to its low sensitivity.…”
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confidence: 99%
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“…protein. 4 However, this serological test often gives falsenegative results due to a low number of bacilli or low antibody levels. 4 The sensitivity of the serological test on PB-type leprosy ranges only between 15% and 40%.5 Therefore, serological testing is not recommended for diagnosing PB-type leprosy due to its low sensitivity.…”
mentioning
confidence: 99%
“…4 However, this serological test often gives falsenegative results due to a low number of bacilli or low antibody levels. 4 The sensitivity of the serological test on PB-type leprosy ranges only between 15% and 40%.5 Therefore, serological testing is not recommended for diagnosing PB-type leprosy due to its low sensitivity. 5 Histopathological testing, which is carried out by performing skin biopsy, is currently the gold standard diagnostic test for leprosy.5 However, the test has several limitations because it is invasive and impractical.…”
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confidence: 99%
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“…reação de Mitsuda foi incorporada aos critérios de classificação da hanseníase no ano de 1953, no Sexto Congresso Internacional de Madri, como auxílio na classificação da forma clínica da doença. Ficou deliberado que a reação positiva seria associada a pacientes tuberculoides, e negativa a pacientes virchowianos1,46 . Em pacientes dimorfos a positividade da reação diminui gradativamente perto do polo Virchowiano e aumenta progressivamente à medida que se aproxima o polo tuberculoide46 .…”
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“…Ficou deliberado que a reação positiva seria associada a pacientes tuberculoides, e negativa a pacientes virchowianos1,46 . Em pacientes dimorfos a positividade da reação diminui gradativamente perto do polo Virchowiano e aumenta progressivamente à medida que se aproxima o polo tuberculoide46 . Quando negativa, há opiniões controversas: de que não tem valor preditivo para definir o polo de evolução 37 e de que esses casos sempre evoluem para formas bacilíferas 1 .Na forma tuberculoide observam-se lesões granulomatosas tuberculoides organizadas, caracterizadas por histiócitos epitelioides e células gigantes multinucleadas tipo Langhans, rodeadas por linfócitos T CD4 e CD8.…”
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