Leprosy: diagnosis and management in a developed setting

Turner, David P.; McGuinness, Sarah L.; Leder, Karin

doi:10.1111/imj.12638

Cited by 19 publications

(16 citation statements)

References 8 publications

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“…Other atypical presentations reported in the literature include ocular (keratitis, uveitis) [ 4 ] and upper airway involvement (laryngitis) [ 2 ]. Leprosy has been classified into 2 polar forms (lepromatous and tuberculoid) with 3 borderline disease patterns in between [ 5 ]. This is a result of a genetically predetermined immune response in different individuals [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy

Fwoloshi¹,

Machona²,

Mudenda³

et al. 2015

Pan Afr Med J

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Leprosy is a granulomatous disease that mainly affects the skin and peripheral nerves. It is caused by infection with mycobacterium leprae or mycobacterium lepromatosus. In most instances, diagnosis of leprosy can easily be made based on the clinical signs and symptoms. However, when patients present with atypical features, clinical diagnosis can be a challenge. We report a case of a nursing mother with lepromatous leprosy who presented with dysphonia and skin lesions initially thought to be a deep cutaneous mycosis.

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Section: Discussionmentioning

confidence: 99%

Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy

Fwoloshi¹,

Machona²,

Mudenda³

et al. 2015

Pan Afr Med J

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“…A surgical biopsy of the involved nerve can be performed to confirm or exclude the presence of chronic perineural or endoneurial neuritis with a mixed inflammatory cell infiltrate consisting of lymphocytes, macrophages and eosinophils. Polymerase chain reaction can be performed for detection of Mycobacterium Leprae DNA . Referral to an infectious diseases specialty unit for further investigations should be instigated where slit skin smears from eyebrows and cheeks may be obtained.…”

Section: Leprosymentioning

confidence: 99%

“…The drugs used are a combination of rifampicin, clofazimine and dapsone for multibacillary leprosy and rifampicin and dapsone for paucibacillary leprosy. In Australia, patients with non‐tuberculoid leprosy are treated for 2 years . Orofacial neuropathic pain secondary to leprosy can be managed with drugs with proven efficacy such as tricyclic antidepressants and anticonvulsants.…”

Section: Leprosymentioning

confidence: 99%

Systemic considerations for orofacial neuropathy

Tiwari

Alsarraf

Yeoh³

et al. 2018

Aust Endodontic J

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Patients with orofacial neuropathic pain typically present with symptoms first hand to their general dental practitioner. It is important dental practitioners recognise the clinical presentations of these conditions for prompt diagnosis and appropriate management. This review will focus on the systemic causes of orofacial neuropathy. Infectious and autoimmune diseases with orofacial neuropathic manifestations such as post-herpetic neuralgia, paroxysmal neuralgias, painful trigeminal sensory neuropathies, peripheral neuritis and oral dysaesthesia will be discussed. Specifically, the prevalence, pathophysiology, clinical presentations and management of these conditions will be reviewed. Post-herpetic neuralgiaPost-herpetic neuralgia (PHN) is a chronic neuropathic pain condition persisting 3 months or greater following reactivation of varicella zoster virus (3). This peripheral system neuropathy results from damage to nervous tissue secondary to a herpes zoster attack. It is the most common neuropathic pain resulting from infection (4).Post-herpetic neuralgia has the potential to cause longterm severe pain, contributing to marked psychosocial dysfunction in the form of impaired sleep, decreased appetite and diminished libido (3,5). The impact of this condition can be drastic enough to transform independent living to dependent care (5).

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“…Der Eine wesentliche Einschränkung einer möglichen Diagnostik von Lepra ist, dass die typischen Zeichen der Infektion anhand des klinischen Bildes zu spät festgestellt werden [116].…”

Section: Serologischer Und Zellgebundener Nachweisunclassified

Mycobacterium leprae – der Erreger von Lepra

2016

Bundesgesundheitsbl

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Der Arbeitskreis Blut des Bundesministeriums für Gesundheit gibt als nationales Beratungsgremium Stellungnahmen zu neuartigen Erregern ab, bewertet neue Erkenntnisse zu bekannten Erregern und erarbeitet entsprechende Empfehlungen für die Fachöffentlichkeit. Diese Serie von Stellungnahmen zu einzelnen Erregern wird als Zusammenfassung des aktuellen Wissensstandes veröffentlicht, speziell unter transfusionsmedizinisch relevanten Aspek

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Leprosy: diagnosis and management in a developed setting

Cited by 19 publications

References 8 publications

Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy

Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy

Systemic considerations for orofacial neuropathy

Mycobacterium leprae – der Erreger von Lepra

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