Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia

Chen, Vincent Chin Hung; Chen, Chun Hsin; Chiu, Yu‐Hui; Lin, Tsang Yaw; Li, Feng Chiao; Lu, Mong Liang

doi:10.1016/j.psyneuen.2018.03.021

Cited by 46 publications

(37 citation statements)

References 53 publications

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“…In the present study, we aimed to confirm the results of previous reports of increased serum cytokines and adipokine levels in patients with schizophrenia [ 39 ], as well as their association with metabolic parameters [ 18 , 40 ]. In addition, we wanted to assess the possible correlation of adipokine levels with body fat composition and biochemical parameters depending on the presence of MetS.…”

Section: Introductionsupporting

confidence: 62%

“…However, only patients with schizophrenia but without MetS demonstrated a relationship between leptin and visceral fat levels. In other studies of patients with schizophrenia, both adiponectin and leptin levels were found to be associated with most metabolic parameters, which may be due to the fact that the assessment did not take into account the presence of MetS [ 18 , 40 ].…”

Section: Discussionmentioning

confidence: 98%

“…Apart from a range of metabolic effects [ 14 , 15 ], leptin is linked by many other pathophysiological effects to cardiovascular morbidity [ 16 , 17 ]. Remarkably, elevated leptin levels have also been observed in patients with schizophrenia [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

et al. 2020

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The adipokines leptin, adiponectin, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) might be associated with metabolic syndrome (MetS) in patients with schizophrenia. In the present study, we attempted to confirm the results of previous reports and assessed their MetS-related correlation with body fat composition and biochemical parameters. We measured in 46 patients with schizophrenia and MetS serum levels of adiponectin insulin, leptin, TNF-α and IL-6 and compared these levels to those of patients with schizophrenia without MetS. The MetS patients had significantly increased leptin levels and leptin/adiponectin ratios, as well as decreased adiponectin levels. Leptin levels correlated with several metabolic parameters, both in patients with and without MetS, including body fat percentage, total fat fold, and body mass index (BMI). Patients without abnormal MetS components had lower levels of leptin and leptin/adiponectin ratios compared with patients who had one or two MetS components. Leptin/adiponectin ratios were higher in patients who had four rather than three MetS components. Multiple regression analysis revealed multiple associations for leptin but only one for adiponectin, TNF-α, and IL-6. Our results support an important pathophysiological role for leptin more than adiponectin in patients with schizophrenia with MetS.

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Section: Introductionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 98%

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Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

et al. 2020

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“…Many studies have concluded that plasma leptin and adiponectin are associated with obesity and MetS, and can be used as diagnostic markers for MetS [ 51 ]. The LAR may be useful to identify subjects susceptible to metabolic risk, and may reflect the functionality of adipose tissue [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of personalized moderate exercise training on Wistar rats fed with a fructose enriched water

et al. 2018

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BackgroundMetabolic Syndrom has become a public health problem. It mainly results from the increased consumption of fat and sugar. In this context, the benefits of personalized moderate exercise training were investigated on a metabolic syndrome male wistar rat model food with fructose drinking water (20–25% w/v). Different markers including body weight, metabolic measurements, blood biochemistry related to metabolic syndrome complications have been evaluated.MethodsMale Wistar rats were randomly allocated to 4 groups: control (sedentary (C, n = 8) and exercise trained (Ex, n = 8)), fructose fed (sedentary (FF, n = 8) and exercise trained fructose fed rats (ExFF, n = 10)). ExFF and Ex rats were trained at moderate intensity during the last 6 weeks of the 12 weeks-long protocol of fructose enriched water. Metabolic control was determined by measuring body weight, fasting blood glucose, HOMA 2-IR, HIRI, MISI, leptin, adiponectin, triglyceridemia and hepatic dysfunction.ResultsAfter 12 weeks of fructose enriched diet, rats displayed on elevated fasting glycaemia and insulin resistance. A reduced food intake, as well as increased body weight, total calorie intake and heart weight were also observed in FF group. Concerning biochemical markers, theoretical creatinine clearance, TG levels and ASAT/ALAT ratio were also affected, without hepatic steatosis. Six weeks of 300 min/week of moderate exercise training have significantly improved overweight, fasting glycaemia, HOMA 2-IR, MISI without modify HIRI. Exercise also decreased the plasma levels of leptin, adiponectin and the ratio leptin/adiponectin. Regarding liver function and dyslipidemia, the results were less clear as the effects of exercise and fructose-enriched water interact together, and, sometimes counteract each other.ConclusionOur results indicated that positive health effects were achieved through a personalized moderate training of 300 min per week (1 h/day and 5 days/week) for 6 weeks. Therefore, regular practice of aerobic physical exercise is an essential triggering factor to attenuate MetS disorders induced by excessive fructose consumption.

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“…It also plays an important role in the regulation of body metabolism, energy homeostasis, and neuroendocrine function [14]. It acts by binding to circulating receptors, triggers Janus kinase, and induces signal transducer and activator of transcription pathway [15]. Increased leptin directly modulates pancreatic beta cells functions and indirectly through central neural pathways leading to progression of IR and T2DM [4,16].…”

Section: Introductionmentioning

confidence: 99%

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

Singh

Mahajan

Kaur

2019

Asian J Pharm Clin Res

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Objective: This study was done to explore the correlation if any, between obesity markers adiponectin, leptin, and protein oxidative stress (OS) status in obese with and without type 2 diabetic mellitus (T2DM) patients. Methods: In the present study, 30 healthy subjects, 30 obese non-diabetics, and 30 obese T2DM patients were enrolled. Protein OS parameters such as advanced oxidation of protein products (AOPPs) and protein carbonyl (PC) were estimated. Serum leptin, adiponectin, and insulin levels were measured by ELISA. Results: The AOPP, PC, leptin, leptin adiponectin ratio (LAR), insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) levels were significantly higher in obese non-diabetic and obese T2DM as compared to healthy control (p<0.001). However, serum adiponectin levels were significantly lower in obese non-diabetic and obese T2DM as compared to control (p<0.001). HOMA-IR and LAR both the index of IR were increased in obese non-diabetic and obese T2DM. Positive correlations were observed for AOPP with body mass index, PC in obese non-diabetic and with fasting blood glucose, postprandial blood glucose, HOMA-IR, and PC in obese T2DM. A negative correlation was found between PC and adiponectin in obese non-diabetic and obese T2DM. A significant inverse correlation was obtained between leptin and adiponectin in obese T2DM only. Conclusion: The present study suggested that increased protein OS, hyperinsulinemia, and hyperleptinemia may lead to hypoadiponectinemia in obese with and without T2DM. Moreover, determination of protein oxidation markers can be useful for monitoring the dysregulation of adipokines and glucose metabolism in obesity and T2DM.

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Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia

Cited by 46 publications

References 53 publications

Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia

Effect of personalized moderate exercise training on Wistar rats fed with a fructose enriched water

Study of Relationship Between the Protein Oxidation Markers and Adipokines in Obese Type 2 Diabetic Patients

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