Leptin and body mass index in polycystic ovary syndrome

Jalilian, Nasrin; Haghnazari, Lida; Rasolinia, Samira

doi:10.4103/2230-8210.180005

Cited by 29 publications

(30 citation statements)

References 35 publications

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“…In fact, Montazerifar et al indicated that Leptin levels were significantly higher in abdominal obese patients than those in patients without abdominal obesity or in the control group. This result was partly consistent with earlier reports …”

Section: Discussionsupporting

confidence: 94%

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers

Zayani

Hamdouni

Boumaiza

et al. 2018

Int J Experimental Path

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Adipose tissue is an important endocrine organ that secretes a number of adipokines, like Leptin (LEP). The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity. We recruited 169 non-obese (body mass index [BMI] = 24.51-3.69 kg/m ) and 160 obese (BMI = 36-4.78 kg/m ) patients. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism, BMI was calculated, and Leptin level was measured by ELISA. Statistical analyses were performed by spss19.0. According to LEP 3'UTR A/C polymorphism, AC and CC genotype carriers had higher Leptin levels than AA genotype carriers, respectively, 31[0.05-148.8] (P = .008) vs 41[0.05-111.6] (P = .003). The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001). Concerning LEP G2548A polymorphism, our results showed that the OR of obesity associated with 2548 AA/GG was 1.87[1.106-2.78] P = .028 vs 1.41[1.035-1.85] P = .045 for 223AA/GG polymorphism. In our haplotype analysis, one haplotype seems to be the more protective and one other seems to be the highest risk to obesity. LEP 3'UTR A/C and LEPR K109R polymorphisms were associated with Leptin level and obesity.

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Section: Discussionsupporting

confidence: 94%

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers

Zayani

Hamdouni

Boumaiza

et al. 2018

Int J Experimental Path

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“…101 Upregulation of adipokine mRNA in peripheral adipose tissues has been associated with PCOS, obesity, and hyperinsulinemia. 102 , 103 Future directions for our studies could investigate the synthesis and release of androgens and adipokines into circulation and determine whether this also contributes to hyperandrogenemia or increased risks of cardiovascular disease in women with PCOS and other disorders that fall under metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

et al. 2018

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Background: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant. Therefore, we hypothesized that the hypertension seen in PCOS has early origins in gut dysbiosis caused by in utero exposure to excess androgen. We investigated this hypothesis with a model of prenatal androgen (PNA) exposure and maternal hyperandrogenemia by single-injection of testosterone cypionate or sesame oil vehicle (VEH) to pregnant dams in late gestation. We then completed a gut microbiota and cardiometabolic profile of the adult female offspring. Results: The metabolic assessment revealed that adult PNA rats had increased body weight and increased mRNA expression of adipokines: adipocyte binding protein 2, adiponectin, and leptin in inguinal white adipose tissue. Radiotelemetry analysis revealed hypertension with decreased heart rate in PNA animals. The fecal microbiota profile of PNA animals contained higher relative abundance of bacteria associated with steroid hormone synthesis, Nocardiaceae and Clostridiaceae, and lower abundance of Akkermansia, Bacteroides, Lactobacillus, Clostridium. The PNA animals also had an increased relative abundance of bacteria associated with biosynthesis and elongation of unsaturated short chain fatty acids (SCFAs). Conclusions: We found that prenatal exposure to excess androgen negatively impacted cardiovascular function by increasing systolic and diastolic blood pressure and decreasing heart rate. Prenatal androgen was also associated with gut microbial dysbiosis and altered abundance of bacteria involved in metabolite production of short chain fatty acids. These results suggest that early-life exposure to hyperandrogenemia in daughters of women with PCOS may lead to long-term alterations in gut microbiota and cardiometabolic function.

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“…Polycystic ovary syndrome (PCOS) has been considered the most common multifactorial endocrinopathy syndrome [ 1 , 2 ], which affects about 15% of reproductive age women [ 2 , 3 ]. It is a heterogeneous condition characterized by chronic anovulation, hyperandrogenism [ 4 , 5 ], and polycystic ovarian morphology [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice

Correia

Almeida

Simões

et al. 2017

BioMed Research International

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We aim to assess the effects of metformin treatment on metabolic and endocrine parameters and genes expression related to the insulin-responsive pathway in polycystic ovary syndrome (PCOS). This study comprises twenty-eight obese mice divided into three metformin-treated groups for seven and twenty days and eight nonobese and nontreated ones. We found a significant decrease in glycemia after metformin treatment at days seven and twenty. However, we did not observe differences in body weight measurement. Histologically, after twenty days we observed follicular development with regression of androgenic effects. Levels of IGF-1R protein expression were low after twenty days of treatment, but LEP proteins showed an overexpression in the ovarian stroma. We assessed the IGF-1R and LEP mRNAs levels; data showed a significant overexpression of LEP after seven days of treatment, while the IGF-1R was downregulated. Metformin therapy seems to exert a beneficial effect on histological and anovulatory features, reducing follicular number and pyknosis formation, possibly involved in the reversion of androgenic stimulus. Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.

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Leptin and body mass index in polycystic ovary syndrome

Cited by 29 publications

References 35 publications

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers

Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

IGF-1R and Leptin Expression Profile and the Effects of Metformin Treatment on Metabolic and Endocrine Parameters in PCOS Mice

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