Leptin at gender-specific concentrations does not affect glucose transport, expression of glucose transporters and leptin receptors in human lymphocytes

Pliszka, Monika; Oleszczak, B; Szablewski, Leszek

doi:10.1007/s12020-014-0435-3

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…Following lymphocyte activation, ObR expression shifted to a higher intensity and density ( 26 ). ObR expression, particularly that of the long isoform, in normal murine thymocytes is exceedingly low or negative ( 27 ). However, the present study revealed that Jurkat and MOLT-3 cells, which are suspected to develop from thymocytes or thymic progenitors, exhibit a high expression level of ObR.…”

Section: Discussionmentioning

confidence: 99%

Leptin and its receptor in glucose metabolism of T‑cell lymphoma

Han

et al. 2018

Oncol Lett

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T-cell lymphoma (TCL) is a group of heterogeneous disorders with a poor response to conventional treatment. In order to identify novel therapeutic targets, the present study investigated the effect of leptin and its receptor on glucose metabolism in TCL. The expression of the leptin receptor (ObR), and glucose transporter (Glut)1 and 4 was detected in TCL and reactive lymphoid hyperplasia (RLH) tissues by immunohistochemical analysis. A higher level of ObR expression was observed in the TCL tissues than in the RLH tissues (58.3 vs. 22.2%; P=0.012), and ObR overexpression was associated with high expression of Glut1 (P=0.007). In vitro analysis using the human TCL MOLT-3 cell line demonstrated that leptin stimulated cell glucose uptake via promoting recruitment and expression of Glut1, effects which were abolished by ObR-specific small interfering RNA (siRNA). Additionally, MOLT-3 cell viability was also increased following leptin treatment. ObR-specific siRNA abolished these responses. In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR.

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Section: Discussionmentioning

confidence: 99%

Leptin and its receptor in glucose metabolism of T‑cell lymphoma

Han

et al. 2018

Oncol Lett

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“…In our experiments, TGF- β 1 protein levels were significantly higher in db/db mice than in mice in the other groups. This finding suggests that the cell hypertrophy observed in the db group was related to the high expression level of TGF- β 1, which can block ECM degradation [ 26 , 27 ]. Matrix metalloproteinases (MMPs) are enzymes that play key roles in substrate degradation.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1α Signaling in db/db Mice

Hou

Zhang

et al. 2017

Journal of Diabetes Research

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Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD). Glycyrrhizic acid (GA) is an effective inhibitor of reactive oxygen species (ROS) production. We investigated the role of GA in the progression of renal injury in DN. Albumin (Alb)/creatinine (crea) levels were significantly lower, and renal histopathology was attenuated in the diabetic db/db mice that were treated with GA (15 mg/kg via intraperitoneal injection) once per day for eight weeks. These changes were associated with significantly lower levels of α-smooth muscle actin (α-SMA) and transforming growth factor β1 (TGF-β1) expression. Additionally, diabetic db/db mice displayed more terminal deoxynucleotidyl transferase-mediated nick-end labeling- (TUNEL-) positive nuclei and diabetes-induced ROS production in the kidneys, and these effects were attenuated by the treatment with GA, which activated adenosine monophosphate-activated protein kinase (AMPK)/silent information regulator 1 (SIRT1)/peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) signaling in the kidneys. In summary, in diabetic db/db mice, the effect of GA on DN involved, in part, the inhibition of ROS and the activation of AMPK/SIRT1/PGC-1α signaling in the kidneys. GA, therefore, shows therapeutic potential for preventing and treating DN.

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“…It is widely involved in the regulation of various physiological activities of the human body, such as food intake, energy consumption and metabolism, hormone regulation, immunity, and vascular proliferation [ 62 ]. The levels of leptin, as a negative feedback signal of central fat deposition in the brain, increase with increasing fat deposition [ 63 , 64 ]. A study found that human plasma leptin levels and phenylalanine concentrations are positively correlated [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats

Ren,

Zhou,

Shen

2023

Metabolites

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Selenium (Se)-enriched habitats have led to chronic selenosis, seriously affecting the health and survival of Procapra przewalskii (P. przewalskii). Our targets were to explore the molecular mechanisms of chronic selenosis and to look for a new way to protect endangered species. The mineral contents of soils, grass, blood, and muscle were analyzed. The biochemical indices, antioxidant capability, and immune function were also investigated. The analyses of proteomics and metabolomics were also carried out. The results showed that the Se contents in the muscle and blood of P. przewalskii, and the soil and grass in the Se-enriched habitats were significantly higher than those in healthy pastures. The P. przewalskii in the Se-enriched habitats showed symptoms of anemia, decreased antioxidant capability, and low immune function. A total of 44 differential proteins and 36 differential metabolites were screened by analyzing their proteomics and metabolomics. These differential proteins and metabolites were involved in glycolysis pathway, amino acid biosynthesis, carbon metabolism, phenylalanine metabolism, and energy metabolism. In particular, phenylalanine metabolism was the common pathway of proteomics and metabolomics, which was an important finding in studying the mechanism of chronic selenosis in animals. This study will help us to further understand the mechanism of chronic selenosis in P. przewalskii, and it provides a scientific basis for the protection of endangered species in Se-enriched habitats.

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Leptin at gender-specific concentrations does not affect glucose transport, expression of glucose transporters and leptin receptors in human lymphocytes

Cited by 4 publications

References 51 publications

Leptin and its receptor in glucose metabolism of T‑cell lymphoma

Leptin and its receptor in glucose metabolism of T‑cell lymphoma

Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1α Signaling in db/db Mice

Abnormal Phenylalanine Metabolism of Procapra przewalskii in Chronic Selenosis in Selenium-Enriched Habitats

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