Leptin in non PCOS and PCOS women: a comparative study

Ramanand, Sunita J.; Ramanand, Jaiprakash; Jain, Suyog; Raparti, Girish T.; Ghanghas, Ravi R.; Halasawadekar, Nimish R.; Patil, Praveen; Pawar, Mayur P.

doi:10.5455/2319-2003.ijbcp20140224

Cited by 16 publications

(16 citation statements)

References 16 publications

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“…These results are comparable with Telli et al [ 7 ]; they also reported nonsignificant higher leptin levels in PCOS patients as compared to NC. Few other studies have also reported no significant difference in serum leptin levels of PCOS subjects with age and BMI matched controls [ 15 , 16 ]. Olszanecka-Glinianowicz et al (2013) documented considerably higher serum leptin level in PCOS subjects compared to age and BMI matched NC group.…”

Section: Discussionmentioning

confidence: 96%

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Baig

Rehman

Tariq

et al. 2014

International Journal of Endocrinology

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The study aimed to investigate the levels of serum leptin in PCOS females and to correlate it with metabolic and hormonal parameters. Sixty-two PCOS and ninety normal cycling (NC) females with matched age and body mass index (BMI) were recruited for this cross-sectional study. Serum leptin, FSH, LH, E2, free testosterone, progesterone, thyroid profile, and FBG levels were measured. The mean leptin levels in PCOS and NC were not significantly different (45.56 ng/mL ± 1.49 vs 41.78 ± 1.31 ng/mL, P > 0.05); however, leptin levels showed a strong correlation with BMI in PCOS and NC group (r = 0.77, P < 0.0001; r = 0.82, P < 0.0001, resp.). High E2 levels in NC had a significant correlation with leptin whereas FBG correlated with leptin in PCOS (r = 0.51, P = 0.005). TSH had a substantial correlation (r = 0.49, P < 0.005; r = 0.69, P < 0.005) in PCOS and NC, respectively. There was no significant difference found in circulating leptin concentration between PCOS and NC subjects. Leptin levels in PCOS were related with metabolic impairments manifested by disturbance in FBG levels and impairment of reproductive functions in terms of reduced E2 secretion.

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Section: Discussionmentioning

confidence: 96%

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Baig

Rehman

Tariq

et al. 2014

International Journal of Endocrinology

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“…[ 26 ] However, some studies have reported no significant difference in serum leptin levels of PCOS women with age- and BMI-matched controls. [ 27 28 ] Baig et al . in their study revealed that, compared to controls, PCOS women had higher serum leptin levels but it was not significantly different.…”

Section: Discussionmentioning

confidence: 99%

Leptin and body mass index in polycystic ovary syndrome

Jalilian

Haghnazari

Rasolinia

2016

Indian J Endocr Metab

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Objective:Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with obesity. Human and animal studies showed a direct relationship between leptin level and obesity, however, results from different studies were mixed. This study investigated the status of leptin level in PCOS and its relationship with body mass index (BMI) in a group of Iranian women with PCOS.Methods:In this cross-sectional study, 40 women with PCOS and 36 healthy women were assigned to experimental and control groups, respectively. Those in the PCOS group were not prescribed any medications for 3 months prior to the study. Fasting blood samples were then collected during the 2nd or 3rd day of menstruation for laboratory measurement of serum total leptin, blood glucose (fasting blood sugar), serum insulin, follicle-stimulating hormone, and luteinizing hormone (LH).Results:Mean BMI of the PCOS and control groups were 26.62 ± 4.03 kg/m2 and 23.52 ± 2.52 kg/m2, respectively (P = 0.006). The mean total leptin in the PCO group was also 10.69 ± 5.37 ng/mL and 5.73 ± 2.36 ng/mL in the control group (P = 0.0001). A significant relationship was found between leptin level and BMI as well as LH level among women with PCOS (P < 0.05). However, there was no significant correlation between leptin and insulin (P > 0.05).Conclusion:The results of this study indicated an increased leptin level among women with PCOS that positively associated with BMI and LH.

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“…Furthermore, they observed that the serum leptin level was significantly higher in obese PCOS patients compared to lean PCOS and obese non-PCOS patients. The results of the study done by Ramanand S J et al [14] showed that the percentage of women showing higher leptin levels was more in the PCOS group as compared to the control group. The mean leptin level in the PCOS group was significantly higher in the PCOS group as compared to the control group.…”

Section: Discussionmentioning

confidence: 93%

Assessment of Leptin and Prolactin in Women with Polycystic Ovarian Syndrome

Sadaria

Ravi

2019

IJBcRR

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Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women at reproductive age and is characterized by infertility, hirsutism, obesity, insulin resistance, and menstrual irregularities. Leptin, an adipocyte derived hormone, serves as a link relaying metabolic signals to the neuronal networks in the brain to modulate hypothalamo-pituitary- ovarian axis. Circulating leptin correlates strongly with obesity, which is frequently associated with PCOS. PCOS is associated with hyperandrogenemia and relatively high estrogen levels, which could stimulate prolactin secretion. Aims: 1. To assess serum leptin and prolactin in women with PCOS and to compare them with healthy women as controls. 2. To correlate the leptin, prolactin and body mass index (BMI) among a group of PCOS women and healthy women as controls. Methodology: The study was conducted at Kempegowda Institute of Medical Sciences & Hospital, Bangalore. A comparative study was conducted which includes 30 women who has diagnosed with PCOS and 30 healthy women with as controls. The age group for the study was 18 to 35 years. Fasting blood samples were drawn to measure serum leptin and prolactin. BMI was also calculated. Interpretation of data was done using SPSS version 13. Results: Significant positive correlations between leptin levels and BMI in cases and controls (ρ= 0.683, p < 0.001; ρ= 0.485, p = 0.007 respectively) were observed. Mean BMI, leptin and prolactin were found elevated in the PCOS women compared to controls but they were not statistically significant. No significant correlation was found between leptin and prolactin. Conclusion: Leptin levels were correlated with BMI both in PCOS women and in the healthy controls. Leptin may not have a direct role in the pathogenesis of PCOS, as the serum levels were not significantly higher in PCOS women and did not correlate with prolactin.

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Leptin in non PCOS and PCOS women: a comparative study

Cited by 16 publications

References 16 publications

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Serum Leptin Levels in Polycystic Ovary Syndrome and Its Relationship with Metabolic and Hormonal Profile in Pakistani Females

Leptin and body mass index in polycystic ovary syndrome

Assessment of Leptin and Prolactin in Women with Polycystic Ovarian Syndrome

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