Leptin polymorphism rs3828942: risk for anxiety disorders?

Salerno, Pamela Silva Vitória; Bastos, Clarissa Ribeiro; Peres, Ariadni Mesquita; Ardais, Ana Paula; Gazal, Marta; Jansen, Karen; Souza, Luciano Dias de Mattos; Silva, Ricardo Azevedo da; Kaster, Manuella P.; Lara, Diogo R.; Ghisleni, Gabriele

doi:10.1007/s00406-019-01051-8

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…The polymorphism rs3828942 corresponds to a variation in the intron domain of the LEP gene. This polymorphism has nevertheless been repeatedly shown to be associated with clinical CNS-related phenomena [44][45][46][47]. Therefore, it may be shown that this polymorphism itself, or a polymorphism with rs3828942 in equilibrium, has functional consequences.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it may be shown that this polymorphism itself, or a polymorphism with rs3828942 in equilibrium, has functional consequences. These are not necessary related to homeostatic energy regulation because this variant is probably also involved in sleep parameters [45] and anxiety [47]. Interestingly, Salerno and colleagues examined the association of leptin levels and LEP rs3828942 with generalized anxiety disorder (GAD), taking into account gender differences [47].…”

Section: Discussionmentioning

confidence: 99%

“…These are not necessary related to homeostatic energy regulation because this variant is probably also involved in sleep parameters [45] and anxiety [47]. Interestingly, Salerno and colleagues examined the association of leptin levels and LEP rs3828942 with generalized anxiety disorder (GAD), taking into account gender differences [47]. They showed an interaction between this genotype and the diagnosis of GAD based on leptin levels, but only in the male group [p = 0.0139].…”

Section: Discussionmentioning

confidence: 99%

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Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Boiko

Pozhidaev

Paderina

et al. 2022

Genes

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Background: Metabolic syndrome (MetS) is a common complication of long-term treatment of persons with schizophrenia taking (atypical) antipsychotics. In this study, we investigated the existence of an association with polymorphisms of genes for four hormones that regulate energy metabolism. Methods: We recruited 517 clinically admitted white patients (269M/248F) with a verified diagnosis of schizophrenia (ICD-10) and with a stable physical condition. Participants were classified for having or not having MetS and genotyped for 20 single-nucleotide polymorphisms (SNPs) in the genes encoding insulin-induced gene 2 (INSIG2), ghrelin (GHRL), leptin (LEP), and leptin receptor (LEPR). Results: The 139 patients (26.9%) with MetS were significantly more likely to be women, older, and ill longer, and had a larger body mass index (BMI). Four polymorphisms (rs10490624, rs17587100, rs9308762, and rs10490816) did not meet the Hardy–Weinberg equilibrium (HWE) criterion and were excluded. Only genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) had a significant association with MetS. Conclusions: The results of our study suggest that the LEP and INSIG2 genes play a certain causal role in the development of MetS in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Boiko

Pozhidaev

Paderina

et al. 2022

Genes

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show abstract

“…The fat mass has been well investigated as an alternative source of estrogen and other fat mass hormones. Some of these hormones, such as leptin, are anxiolytic and antidepressants (40). So, decreasing FES probably, mediated by the more plasma level of anxiolytic leptin in subjects with higher fat mass value.…”

Section: Discussionmentioning

confidence: 99%

Fat Mass as an Independent Variable to Assess the Possibility of Predicting the Stability in Postmenopausal Women with and Without Osteoporosis

Mofid¹,

Mohebi²,

Darbani³

et al. 2022

Muscle Ligaments and Tendons J

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Purpose. We investigated the effect of fat mass value (based on skinfold thickness) and body mass index (BMI) on the center of pressure sway to assess the possibility of predicting the stability of postmenopausal women with and without osteoporosis during the standing position. Methods. A total of 78 postmenopausal women participated voluntarily in the study. Postmenopausal (aged 55-75 years) women were divided into, osteoporotic, (lumbar T-score ≤ -2.5, n = 51), and nonosteoporotic (lumbar T-score > -1, n = 27) groups. Total body fat mass was assessed based on skinfold measurement. The isometric strength of the lower limb muscle groups was recorded using a digital hand-held dynamometer. Postural sway was determined by measuring the center of pressure (CoP) sway in the anterior-posterior (AP) and mediolateral (ML) direction during a comfortable double stance position, with eyes open. Results. The fat mass value and BMI were significantly lower in the osteoporotic group than in the nonosteoporotic group. The isometric strength of all lower extremity muscle groups was considerably lower in osteoporotic subjects than in the nonosteoporotic group, except for dorsi flexors and knee extensors. In the mediolateral direction, the CoP sway displacement and velocity were significantly higher in the osteoporotic group than in the nonosteoporotic group. Fat mass was a significant independent variable for predicting CoP velocity in the ML direction (VIF = 2.51, p = 0.050). Conclusions. The low-fat mass value is associated with mediolateral postural instability in postmenopausal women. Losing BMI-fat mass and muscle strength may affect postural instability in postmenopausal women. The cautiously strength-balance exercises may be effective for osteoporotic women to improve stability.

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Targeted Sequencing of the LEP Gene in Various Ethnic Groups of Obese Adolescents

Belyaeva,

Bairova,

Ershova

et al. 2024

Russ J Genet

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Leptin polymorphism rs3828942: risk for anxiety disorders?

Cited by 4 publications

References 46 publications

Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome

Fat Mass as an Independent Variable to Assess the Possibility of Predicting the Stability in Postmenopausal Women with and Without Osteoporosis

Targeted Sequencing of the LEP Gene in Various Ethnic Groups of Obese Adolescents

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