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We investigated the effect of a chronic palatable diet rich in simple sugars on memory of different degrees of emotionality in male adult rats, and on hippocampal plasticity markers in different stages of development. On postnatal day (PND) 21, 45 male Wistar rats were divided in two groups, according to their diet: (1‐Control) receiving standard lab chow or (2‐Palatable Diet) receiving both standard chow plus palatable diet ad libitum. At PND 60, behavioral tests were performed to investigate memory in distinct tasks. Hippocampal plasticity markers were investigated at PND 28 in half of the animals, and after the behavioral tests. Palatable diet consumption induced an impairment in memory, aversive or not, and increased Na+, K+‐ATPase activity, both at PND 28, and in the adulthood. Synaptophysin, brain‐derived neurotrophic factor (BDNF), and protein kinase B (AKT), and phosphorylated AKT were reduced in the hippocampus at PND 28. However, at PND 75, this diet consumption led to increased hippocampal levels of synaptophysin, spinophilin/neurabin‐II, and decreased BDNF and neuronal nitric oxide synthase. These results showed a strongly association of simple sugars‐rich diet consumption during the development with memory impairments. Plasticity markers are changed, with results that depend on the stage of development evaluated.

AIM: The aim of this study was to evaluate the prevalence of depressive symptoms and factors associated in the elderly of the city of Pelotas, southern Brazil. METHODS: In this cross-sectional study, the variables of interest were investigated with instruments about the socio-economic profile, aspects of physical and professional activities, eating and sleeping habits. RESULTS: 312 elderly people were interviewed, with a prevalence of depressive symptoms of 30.5%. A higher prevalence of depressive symptoms were found in women, individuals older than 81 years, from the low class, living alone, physically inactive, and retired. In the adjusted analysis, the non-practice of physical activity, low sleep quality, and daily sleeping medication were statistically associated with the outcome. In contradiction to the literature, our results refute the well-established gender roles that preconize that males are more affected by physical impairment, while the females are more affected by psychological and psychiatric disorders. CONCLUSIONS: In conclusion, it is important to identify the prevalence of depressive symptoms in a population commonly affected by other diseases. In addition, characteristics associated with depression were detected, which can help prevent or improve depression in this age group.