2021
DOI: 10.1016/bs.vh.2020.12.006
|View full text |Cite
|
Sign up to set email alerts
|

Leptin regulation of hippocampal synaptic function in health and disease

Abstract: One contribution of 35 to a Discussion Meeting Issue 'Synaptic plasticity in health and disease'.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
5
0
1

Year Published

2021
2021
2023
2023

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 9 publications
(6 citation statements)
references
References 106 publications
0
5
0
1
Order By: Relevance
“…Leptin is transported across the blood–brain barrier (BBB) via a saturable transport system ( Banks, 2004 ) and is a potent modulator of excitatory synaptic transmission at hippocampal CA1 synapses ( Irving and Harvey, 2014 , 2021 ). Consequently, the ability of leptin to regulate excitatory synaptic efficacy at CA1 synapses suggests that leptin is likely to influence cognition processes ( Hamilton and Harvey, 2021 ; Harvey, 2022 ). However, leptin transport across the BBB is impaired in high BMI phenotypes ( Banks et al, 1999 ), which has an adverse effect on the synaptic transmission of hippocampal CA1 ( Grillo et al, 2011 ).…”
Section: Discussionmentioning
confidence: 99%
“…Leptin is transported across the blood–brain barrier (BBB) via a saturable transport system ( Banks, 2004 ) and is a potent modulator of excitatory synaptic transmission at hippocampal CA1 synapses ( Irving and Harvey, 2014 , 2021 ). Consequently, the ability of leptin to regulate excitatory synaptic efficacy at CA1 synapses suggests that leptin is likely to influence cognition processes ( Hamilton and Harvey, 2021 ; Harvey, 2022 ). However, leptin transport across the BBB is impaired in high BMI phenotypes ( Banks et al, 1999 ), which has an adverse effect on the synaptic transmission of hippocampal CA1 ( Grillo et al, 2011 ).…”
Section: Discussionmentioning
confidence: 99%
“…Studies in animal models support the neuroprotective effects of leptin and the administration of exogenous leptin as a possible therapy for AD (Hamilton & Harvey, 2021) (Table 1). Even though there are no clinical trials in humans, a study carried out in congenital cases of leptin deficiency (Paz‐Filho et al, 2015) suggests leptin administration may be a safe treatment.…”
Section: Effects Of Adipokines On the Brain And Cerebrovascular Syste...mentioning
confidence: 98%
“…Sin embargo, el cerebro, que consume mucha energía, no necesita la insulina para absorberla, pero esta hormona llega al cerebro, especialmente al hipocampo, donde se une a receptores específicos y modula mecanismos de plasticidad sináptica subyacentes a los procesos de aprendizaje y memoria [ 46 , 47 ]. La leptina también participa en mecanismos de plasticidad sináptica [ 48 ]. En consecuencia, las alteraciones de la leptina y la insulina no sólo dificultan la regulación de los mecanismos de saciedad en el hipotálamo, sino que también interrumpen mecanismos básicos de formación de la memoria en el hipocampo.…”
Section: Desarrollounclassified