Leptospiral infection in horses in England: a serological study

Hathaway, S.C.; Little, T.W.A.; Finch, S.M.; Stevens, A.E.

doi:10.1136/vr.108.18.396

Cited by 61 publications

(47 citation statements)

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“…However in a recent study, it was demonstrated that seroreactivity against serovar Bratislava was more likely to be associated with reproductive problems than seroreactivity against serovar Copenhageni in horses (Pinna et al 2014). None of these clinical signs above mentioned were associated with seropositivity of horses to Leptospira spp, indicating that most leptospiral infections in horses are asymptomatic (Hathaway et al 1981). …”

Section: Management Factorsmentioning

confidence: 98%

“…2001). These maintenance hosts, which include numerous wild and domestic animal species, serve as a source of infection for incidental or accidental hosts (Hathaway et al 1981). They can easily become infected but they develop mild or no clinical signs.…”

Section: Epidemiology Of Leptospirosismentioning

confidence: 99%

“…Although most leptospiral infections in horses are asymptomatic (Hathaway et al 1981, Hajikolaei et al 2005, Verma et al 2013, the most frequently recognized clinical manifestations of leptospirosis in horses are recurrent uveitis and periodic ophthalmia (Levett. 2001, Verma andStevenson.…”

Section: Introductionmentioning

confidence: 99%

“…The disease has been associated with reproductive tract infection (Divers and Chang. 2009) in pregnant mares which can result in placentitis, abortion or stillbirths (Bernard et al 1993, Timoney et al 2011, renal disease in young horses (Quinn et al 2011) and hepatic dysfunction (Hathaway et al 1981).…”

Section: Introductionmentioning

confidence: 99%

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A study of leptospirosis in South African horses and associated risk factors

Simbizi

Saulez²,

Potts

et al. 2016

Preventive Veterinary Medicine

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between potential risk factors and both seropositive horses to the predominant serovar Bratislava and to Leptospira spp were statistically evaluated using univariable analysis and multivariable logistic regression models.Adult horses admitted to each equine hospital and horses seen on ambulatory service for various purposes were included in the study. Severely-ill, chronically infected, and horses with underlying immunosuppressive conditions were excluded from sampling, to control for potential bias.A total of 663 horse sera were collected and tested against a panel of 24 leptospiral serovars using the microscopic agglutination test. The most predominant serovars in Gauteng were The apparent prevalence to one or more serovars of Leptospira spp at a serum dilution of 1:100 in Gauteng, KwaZulu-Natal and Western Cape Provinces was 49%; 37% and 32% respectively. The true prevalence was calculated for each province taking into account the clustering effect during the sampling and was found to be between 24-74% in Gauteng; 26-39% in the Western Cape and 20-54% in KwaZulu-Natal.iv Nooitgedacht (South African horse breed) horses were found to be at greater risk of being seropositive to both serovar Bratislava (OR=5.08) and Leptospira spp (OR=6.3). Similarly, horses residing on properties with forestry in the vicinity were found to be at greater risk of being seropositive to both serovar Bratislava (OR=9.3) and Leptospira spp (OR=5.2). This study has shown that a high proportion of horses in South Africa are exposed to a wide range of serovars, inferring a complex epidemiology. It also describes for the first time new serovars of Leptospira in South African horses that have not previously been reported.v

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Section: Management Factorsmentioning

confidence: 98%

Section: Epidemiology Of Leptospirosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A study of leptospirosis in South African horses and associated risk factors

Simbizi

Saulez²,

Potts

et al. 2016

Preventive Veterinary Medicine

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“…The predominant serogroup in serological reactions varied depending on the country in which the survey was conducted and the leptospiral antigens used (2). The diversity of leptospiral serogroups to which antibodies have been detected and the absence of a predominant serotype to which antibodies were present in most surveys, led Hathaway et al (6) to conclude that the spectrum of leptospiral titres in horse sera from different countries is probably a reflection of exposure to serotypes maintained by other domestic and wild animals in the same geographical area. On the other hand, Ellis et al (2) suggested that Leptospira interrogans serovar bratislava may be adapted to and maintained by the horse population from the very high prevalence of antibodies to a serovar bratislava strain in Northern Ireland, the frequent isolation of this strain from the kidneys of asymptomatic horses and the high prevalence of bratislava titres in some serological surveys in which serovar bratislava was used as a test antigen.…”

Section: Introductionmentioning

confidence: 99%

ClinicalLeptospira interrogansserogroupAustralisserovarlorainfection in a stud farm in the Netherlands

Ingh

Hartman²,

Bercovich³

1989

Veterinary Quarterly

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Subclinical leptospirosis may impair athletic performance in racing horses

Hamond

Martins

Lilenbaum

2012

Trop Anim Health Prod

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The infection by Leptospira in horses, in both its acute disease and subclinical forms, is very common, particularly in endemic regions. Therefore, the objective of this study was to evaluate the effects of subclinical leptospirosis in the athletic performance of racing thoroughbred horses. Athletic performance of 119 racing Thoroughbred horses from Rio de Janeiro, Brazil, was calculated by assigning a point value for the results in racing (performance index (PI)), and serology for leptospirosis was conducted. A total of 85 (71.4 %) horses showed reactive titers (≥ 100), and of which 52 had high titers (34 with 400 and 18 with ≥ 800). Although those animals had high titers against Leptospira, no clinical signs associated with leptospirosis were observed. Seventeen (89.5 %) out of the 19 horses with substandard performance were seroreactive with high titers, in contrast with 35 % of seroreactivity in horses with good athletic performance (P < 0.0001). Additionally, seroreactivity to leptospirosis was more often observed in horses with substandard athletic performance in contrast to those with good performance (P < 0.0001, odds ratio 15.8). The Average PI of this group increased to 133 % after treatment (P < 0.0001). Leptospirosis may impair performance in racing horses, and antibiotic therapy may improve the performance of affected animals.

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Leptospiral infection in horses in England: a serological study

Cited by 61 publications

References 0 publications

A study of leptospirosis in South African horses and associated risk factors

A study of leptospirosis in South African horses and associated risk factors

ClinicalLeptospira interrogansserogroupAustralisserovarlorainfection in a stud farm in the Netherlands

Subclinical leptospirosis may impair athletic performance in racing horses

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