Leptospirosis and Pancreatitis: A Report of Ten Cases

O’Brien, Megan; Vincent, J; Person, Donald A.; Cook, Bruce A.

doi:10.1097/00006454-199805000-00023

Cited by 27 publications

(23 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pancreatitis is described as an uncommon complication of leptospirosis, but there are a considerable number of cases documented in literature 6,15,16,23,26,28,37 . The patients presented epigastric pain and jaundice as the main manifestations of pancreatic involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Beside the elevated pancreatic enzyme levels, the abdominal ultrasound found normal pancreas. O'BRIEN et al 28 , published ten cases of leptospirosis and pancreatitis, diagnosed by elevated serum amylase (> 100 IU/L), and lipase (> 300 IU/L), but without any detectable ultrasound pancreatic morphologic change. CASELLA & SCATENA 6 described a similar case of mild acute pancreatitis and leptospirosis with 1116 IU/L of serum amylase and 802 IU/L of lipase, but also without any ultrasound pancreatic alterations.…”

Section: Discussionmentioning

confidence: 99%

“…The serious occurrences of hepatic, renal and vascular dysfunction, and significant central nervous system symptoms have been well documented 22,29,30 . However, the involvement of the pancreas is not yet well studied in human leptospirosis 6,16,23,26,28,33,37 .…”

Section: Introductionmentioning

confidence: 99%

“…It is suggested that a serum amylase level higher than twice the normal value could not be explained only by renal failure 21 . Others have described several cases of leptospirosis and pancreatitis diagnosed by elevated serum amylase and lipase, but without morphologic change detectable by pancreatic ultrasound 6,16,23,26,28 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features

Daher

Brunetta

Júnior

et al. 2003

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYHyperamylasemia has been reported in more than 65% of patients with severe leptospirosis, and the true diagnosis of acute pancreatitis is complicated by the fact that renal failure can increase serum amylase levels. Based on these data we retrospectively analyzed the clinical and histopathological features of pancreas involvement in 13 cases of fatal human leptospirosis. The most common signs and symptoms presented at admission were fever, chills, vomiting, myalgia, dehydratation, abdominal pain and diarrhea. Trombocytopenia was evident in 11 patients. Mild increased of AST and ALT levels was seen in 9 patients. Hyperamylasemia was recorded in every patient in whom it was measured, with values above 180 IU/L (3 cases). All patients presented acute renal failure and five have been submitted to dialytic treatment. The main cause of death was acute respiratory failure due to pulmonary hemorrhage. Pancreas fragments were collected for histological study and fat necrosis was the criterion used to classify acute pancreatitis. Histological pancreatic findings were edema, mild inflammatory infiltrate of lymphocytes, hemorrhage, congestion, fat necrosis and calcification. All the patients infected with severe form of leptospirosis who develop abdominal pain should raise the suspect of pancreatic involvement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features

Daher

Brunetta

Júnior

et al. 2003

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…Serum amylase levels are often raised significantly in association with ARF (18,175,422), but clinical symptoms of pancreatitis are not a common finding (174,401,439). Necrotizing pancreatitis has been detected at autopsy (175,544).…”

Section: Icteric Leptospirosismentioning

confidence: 99%

Leptospirosis

2001

View full text Add to dashboard Cite

Leptospirosis is a worldwide zoonotic infection with a much greater incidence in tropical regions and has now been identified as one of the emerging infectious diseases. The epidemiology of leptospirosis has been modified by changes in animal husbandry, climate, and human behavior. Resurgent interest in leptospirosis has resulted from large outbreaks that have received significant publicity. The development of simpler, rapid assays for diagnosis has been based largely on the recognition that early initiation of antibiotic therapy is important in acute disease but also on the need for assays which can be used more widely. In this review, the complex taxonomy of leptospires, previously based on serology and recently modified by a genotypic classification, is discussed, and the clinical and epidemiological value of molecular diagnosis and typing is also evaluated

show abstract

Leptospira and Leptospirosis

Faine¹

2015

Current Topics in Microbiology and Immunology

152

View full text Add to dashboard Cite

Leptospirosis and Pancreatitis: A Report of Ten Cases

Cited by 27 publications

References 1 publication

Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features

Pancreatic involvement in fatal human leptospirosis: clinical and histopathological features

Leptospirosis

Leptospira and Leptospirosis

Contact Info

Product

Resources

About