1990
DOI: 10.1136/pgmj.66.773.218
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Leptospirosis presenting as a flaccid paraplegia

Abstract: A fatal case of leptospirosis in a 64 year old farm worker is described. The dramatic neurological presentation with a rapidly evolving flaccid paraplegia associated with biochemical evidence of renal and hepatic dysfunction is discussed. Attention is drawn to the wide range of neurological symptoms reported in leptospirosis, and to the possibility that this infectious disease may present neurologically.

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Cited by 26 publications
(30 citation statements)
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“…The most commonly reported syndromes include encephalitis, myelitis, cerebrovascular accidents, cerebral angiitis, mononeuritis multiplex, polyneuropathy, cranial nerve palsies, and movement disorders (2,4,6,7,8). The majority of these complications occur in the later course of the disease, during the immune phase.…”
Section: Discussionmentioning
confidence: 99%
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“…The most commonly reported syndromes include encephalitis, myelitis, cerebrovascular accidents, cerebral angiitis, mononeuritis multiplex, polyneuropathy, cranial nerve palsies, and movement disorders (2,4,6,7,8). The majority of these complications occur in the later course of the disease, during the immune phase.…”
Section: Discussionmentioning
confidence: 99%
“…These proposed pathogenic mechanisms have not been completely elucidated (4). Diffuse vasculitis occurring during and after the initial phase seems to be responsible for most of the neurological syndromes, while circulating immune complexes could be associated with the other syndromes observed in the second (immune) phase of the disease.…”
Section: Discussionmentioning
confidence: 99%
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“…12 The fulminant icteric form is characterised by fever, myalgia, jaundice, renal failure, haemoptysis and reticulo-nodular infiltrates, thrombocytopenia, headache, nausea, disseminated intravasal coagulation, or aseptic meningitis. 3,[13][14][15] Rare manifestations are uveitis, cotton-wool spots, myocarditis, pericarditis, or rhabdomyolysis. 10,12,16 Neurologic manifestations of leptospirosis include meningitis, encephalitis, coma, seizures, hemi-syndrome, myelitis, movement disorders, Bell's palsy, polyradiculitis, paraplegia, polyneuropathy, myositis, or rhabdomyolysis.…”
mentioning
confidence: 99%
“…10,12,16 Neurologic manifestations of leptospirosis include meningitis, encephalitis, coma, seizures, hemi-syndrome, myelitis, movement disorders, Bell's palsy, polyradiculitis, paraplegia, polyneuropathy, myositis, or rhabdomyolysis. 9,14,17 These could result from a direct effect of the spirochete or from the host's immune response. 9 Spirochetes can be cultured from the CSF during the first week of infection, 14,17,18 but usually disappear from CSF before meningitis manifests clinically.…”
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confidence: 99%