Les Alcaloïdes majoritaires du<i>Strychnos scheffleri</i>du Zaire

Caprasse, M.; Angenot, Luc

doi:10.1055/s-2007-971656

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…The minor alkaloids were identified as strychnofendlerine (figure 1) (5-8) and isosplendine (figure 1) (5,9,10) by means of spectral data by comparison (Rf, ir, uv, ms, 'H-nmr) with authentic samples. One of the major alkaloids proved, by spectral data and by comparison (Rf, 'H-nmr, ir, uv, ms) with an authentic sample, to be identical to strychnobrasiline (figure 2) (5,7,10,11). The second major alkaloid was not identical with any of the indole alkaloids recorded in the literature.…”

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confidence: 78%

“…With the exception of the new alkaloid, l4^-hydroxy-strychnobrasiline, the alkaloids of S. soubrensis have previously been isolated from other sources. strychnobrasiline strychnofendlerine isosplendine S.fendleri{ 5,6) X X S. scheffleri (7) X X S. aculeata (8) X S. splendens (9) S. brasiliensis (10) X S. tabascana (11) X S. splendens and S. scheffleri belong to the same section (Lanigerae) as S. soubrensis, and the three species are said to be closely allied to one another (1).…”

Section: Discussionmentioning

confidence: 99%

“…Strychnobrasiline {figure 2a). Uv(EtOH): 250, 277(sh) nm; ir(KBr): 7.53(dJ=8Hz, H-12), 7.32-6.97 (m, 3H, H-9, H-10, H-ll), 6.01 (s, 1H, H-21), 5.26 (d,J=8 Hz, H-2), 4.64 (d,_/=8 Hz, H-2), 2.34 (s, 3H, ,-acetyl), 2.22 (s, 3H, Nb-methyl), 1.37 (d, 3H,_/=6.2 Hz, C-19 Ch3) ppm; ms(70 eV 175°) mlz (relative intensity): l4-$-hydroxy-strychnobrasiline (figure 2b). Uv(EtOH): 9), 325 (6), 323 (12), 311(4), 296(5), 251(4), 255(6), 227 (5), 210 (6), 202 (12), 196 (9), 194 (5), 186 (17), 185 (9), 182 (7), 180 (9), 170 (10), 168 (12), 166 (9), 152(37), 144(83), 143(33), 130(38), 122 (19), 110(34), 108(38), 96(28).…”

Section: Methodsmentioning

confidence: 99%

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Alkaloids of Strychnos soubrensis

Ohiri¹,

Verpoorte²,

Svendsen³

et al. 1983

J. Nat. Prod.

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A phytochemical investigation of the chloroform extract of the stern bark of Strychnos soubrenszs Hutch. et Dalz. (Loganiaceae) resulted in the isolation of four alkaloids. Three of them were identified as strychnobrasiline, strychnofendlerine, and isosplendine. The fourth one is a new alkaloid for which we propose the structure 14-P-hydroxy-srrychnobrasiline.The African species of Strychnos has been the object of systematic research in recent years. However, whereas some species have been extensively investigated, others have received little or no attention. Therefore, so far, the knowledge of the African Strychnos species is not complete. In an effort to supply some of the missing information, we investigated the alkaloids of the stem bark of Strychnos soubrenszs Hutch. et Dah.Strychnos soubvenszs (1) (section Lanigerae) is a liana or scandent shrub, 10-50 m long, up to 40 m high, climbing in trees. It is widely distributed in the West African rain or secondary forests, often on river banks, at altitudes of 0-1000 m. The bark is pale grey to dark brown with large lenticels.Preliminary phytochemical ( 2 ) and pharmacological (3,4) studies revealed that the small amount of alkaloids present (

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confidence: 78%