Les organoïdes pulmonaires

Bourguignon, Chloé; Vernisse, Charlotte; Mianné, Joffrey; Fieldès, Mathieu; Ahmed, Engi; Petit, Audrey; Vachier, Isabelle; Bertrand, Thierry Lavabre; Assou, Saïd; Bourdin, Arnaud; Vos, John De

doi:10.1051/medsci/2020056

Cited by 2 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lung is composed of more than 40 different cell types that form a complex three-dimensional (3D) anatomic architecture ( 69 ). Generating lungs in vitro and mimicking their function is a major challenge that requires a high degree of cell specialization and complex tissue architecture ( 5 , 48 , 70 , 71 ). They must provide a variety of organ functions, such as the diversity of airway cell types, the defense mechanisms that protect the upper airways (e.g., secretion of specifically composed mucus and active ciliary apparatus), and the coupling of the alveolar space with the surrounding systemic and pulmonary vasculature to ensure effective tissue perfusion and gas exchange ( 72 ).…”

Section: Tissue Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Regenerative medicine in lung diseases: A systematic review

Adamič

Vengušt²

2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Regenerative medicine has opened the door to the exploration of new therapeutic methods for the treatment of various diseases, especially those associated with local or general disregulation of the immune system. In pulmonary diseases, new therapeutic strategies have emerged that are aimed at restoring functional lung tissue rather than alleviating symptoms. These strategies focus on tissue regeneration using stem cells and/or their derivatives or replacement of dysfunctional tissue using biomedical engineering. Animal health can directly benefit from regenerative therapy strategies and also serve as a translational experimental model for human disease. Several clinical trials have been conducted to evaluate the effects of cellular treatment on inflammatory lung disease in animals. Data reported to date show several beneficial effects in ex vivo and in vivo models; however, our understanding of the mechanisms that regenerative therapies exert on diseased tissues remains incomplete.

show abstract

Section: Tissue Engineeringmentioning

confidence: 99%

“…This is a 3D structure that replicates the microanatomy of the desired organ. The formation of organoids relies on the self-assembly of cells derived from adult tissues, embryonic stem cells, or induced pluripotent stem cells ( 70 , 71 , 73 , 74 ).…”

Section: Tissue Engineeringmentioning

confidence: 99%

Regenerative medicine in lung diseases: A systematic review

Adamič

Vengušt²

2023

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

Methods of Sputum and Mucus Assessment for Muco-Obstructive Lung Diseases in 2022: Time to “Unplug” from Our Daily Routine!

Charriot

Volpato

Petit

et al. 2022

Cells

Self Cite

View full text Add to dashboard Cite

Obstructive lung diseases, such as chronic obstructive pulmonary disease, asthma, or non-cystic fibrosis bronchiectasis, share some major pathophysiological features: small airway involvement, dysregulation of adaptive and innate pulmonary immune homeostasis, mucus hyperproduction, and/or hyperconcentration. Mucus regulation is particularly valuable from a therapeutic perspective given it contributes to airflow obstruction, symptom intensity, disease severity, and to some extent, disease prognosis in these diseases. It is therefore crucial to understand the mucus constitution of our patients, its behavior in a stable state and during exacerbation, and its regulatory mechanisms. These are all elements representing potential therapeutic targets, especially in the era of biologics. Here, we first briefly discuss the composition and characteristics of sputum. We focus on mucus and mucins, and then elaborate on the different sample collection procedures and how their quality is ensured. We then give an overview of the different direct analytical techniques available in both clinical routine and more experimental settings, giving their advantages and limitations. We also report on indirect mucus assessment procedures (questionnaires, high-resolution computed tomography scanning of the chest, lung function tests). Finally, we consider ways of integrating these techniques with current and future therapeutic options. Cystic fibrosis will not be discussed given its monogenic nature.

show abstract

Les organoïdes pulmonaires

Cited by 2 publications

References 45 publications

Regenerative medicine in lung diseases: A systematic review

Regenerative medicine in lung diseases: A systematic review

Methods of Sputum and Mucus Assessment for Muco-Obstructive Lung Diseases in 2022: Time to “Unplug” from Our Daily Routine!

Contact Info

Product

Resources

About