Leser-Trélat sign in metastatic melanoma to pleura

Pereira, Raquel; Carvalho, Sofia Daniela; Cruz, João

doi:10.1136/bcr-2018-228834

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…6 A further association of LTS with a metastatic melanoma of unknown primary was reported in a 71-years-old women as the onset of maculopapular lesions of violet-brown colour, pruritic, located on the right posterior thoracic region diagnosed clinically as seborrheic keratosis. 7 However, in such patient those lesions seem to be disposed in a dermatomeric fashion and do not exhibit the typical clinical hyperkeratotic surface and stuck on waxy aspect, 2,7 thus in our view, the lesions should be more likely reinterpreted as zosteriform skin metastasis from melanoma. 8 In this brief literature review of melanoma-associated LTS, the median age of patients (71 years-old, 3 males and 2 females) is in line with previous data of LTS with internal malignancy.…”

Section: Discussionmentioning

confidence: 71%

Leser-Trélat sign as a rare manifestation of cutaneous melanoma

et al. 2020

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Leser-Trélat Sign (LTS) is a rare paraneoplastic syndrome characterized by the sudden eruption of multiple seborrheic keratoses in patients with internal malignancy, commonly localized in the gastrointestinal tract. We report an 80-year-old female patient showing a rapid increase in the number and size of seborrheic keratosis associated with the diagnosis of a cutaneous nodular melanoma (Breslow thickness: 4.5 mm) located on the right flank. After the excision of melanoma, subsequent staging procedures resulted negative, moreover no evidence of melanoma recurrence and no changes of the seborrheic keratoses was detected after a follow-up of 52 months. Although the association between melanoma and Leser Trelat sign is rare, an accurate skin examination with the aid of dermatoscopy searching for undiagnosed skin cancers, should be suggested in patient with sudden eruption of keratosis seborrheic to early diagnose and treat a possible melanoma.

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Section: Discussionmentioning

confidence: 71%

Leser-Trélat sign as a rare manifestation of cutaneous melanoma

et al. 2020

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“…In the previously documented cases of melanoma with associated LTS, the LTS pattern was a definite spread of prominent maculopapular nodular SKs [ 1 - 5 ]; while this case is a pattern of subtle macular SKs similar to other malignancies such as adenocarcinoma [ 13 , 14 ]. This exemplifies the variability of the LTS and highlights a distinct subtle pattern with melanoma.…”

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

“…There have been few cases of Leser-Trélat sign (LTS) in the literature, specifically associated with melanoma [1][2][3][4][5]. LTS is defined as a paraneoplastic syndrome with acute onset of multiple seborrheic keratoses (SKs), a cutaneous marker that is secondary to primary tumor or malignancy [1,[5][6][7][8]. LTS was first characterized in the 1800s by Edmund Leser and Ulysse Trélat, as a cutaneous pattern with sudden eruption of cherry angiomas in oncologic patients, with additional descriptions by Hollander in 1900 regarding the appearance of seborrheic keratoses [1,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Rare cases may present with breast, liver, pancreas, bladder, kidney ovary, prostate, nasopharyngeal carcinoma, uterus, lymphoma, melanoma, and lung cancer [1,6,11,12]. To our knowledge, there have only been five cases documented on LTS secondary to cutaneous melanoma [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Variability of Leser-Trélat Sign Secondary to Melanoma In Situ

Silveri,

James,

Dickens

2024

Cureus

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Leser-Trélat sign (LTS) is characterized as an eruptive display of multiple seborrheic keratoses (SKs) in association with malignancy. This case highlights the variable presentation of LTS secondary to melanoma. To our knowledge, this LTS pattern is the first case where the sign manifests as a subtle pattern secondary to melanoma. This stands in contrast to the five documented cases in the literature of LTS-melanoma, which exhibited distinctive and eruptive patterns. A 64-year-old Caucasian female presented for a wellness examination. No personal history of skin cancer was noted. Patient displayed an onset proliferation of SKs with an irregular, sub-centimeter macular nevus over her right lateral mid back. A 6mm punch biopsy was significant for melanoma in situ, arising within a lentiginous compound dysplastic nevus, focally abutting one peripheral tissue edge. A re-excision with a minimum of 5mm margins was completed and the specimen was negative for residual in situ melanoma. Because of the rare occurrence of this delicate pattern at the site of the melanoma, this presentation adds to the knowledge surrounding this diagnosis. This case emphasizes the importance of maintaining vigilance regarding skin manifestations associated with disease and highlights the critical importance of observation and identification of subtle physical exam findings.

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