Lesions in the reproductive tract of boars experimentally infected with porcine rubulavirus

Ramírez‐Mendoza, Humberto; Hernández-Jáuregui, P; Reyes‐Leyva, Julio; Zenteno, Edgar; Moreno‐López, J.; Kennedy, S.

doi:10.1016/s0021-9975(97)80018-7

Cited by 50 publications

(20 citation statements)

References 10 publications

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“…In boars experimentally infected with porcine rubulavirus, interstitial mononuclear cell infiltration was observed in atrophic testes and was identified as the most probable cause of seminiferous tubule degeneration (263). Similar testicular lesions were previously observed in rams infected with maedi/ visna virus, in which the atrophy of seminiferous tubules was associated with disturbances in spermatogenesis (248).…”

Section: The Animal Testissupporting

confidence: 64%

“…In contrast, porcine parvovirus DNA, detected in the epididymal semen of oronasally inoculated boars, was found to bind to spermatozoa (128) but seemed to have no negative effect. Lastly, porcine rubulavirus has been reported to reduce sperm quality in sexually mature boars by decreasing spermatozoon motility and concentration (263). Since viral contamination of semen is common in bulls and since frozen semen is widely distributed and is of major economic importance, national and international organizations have laid down guidelines aimed at establishing disease-free bull studs producing semen free from potential pathogens.…”

Section: Animal Semenmentioning

confidence: 99%

“…Swelling of the head of the epididymis was observed in boars inoculated with porcine rubulavirus, which causes "blue eye" disease, resulting in infertility in sows and boars and corneal opacity in pigs of all ages (263). The lesion was associated with mononuclear cell infiltration and interstitial fibroplasia.…”

Section: Animal Seminal Vesicles and Epididymismentioning

confidence: 99%

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Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

290

220

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This review describes the various viruses identified in the semen and reproductive tracts of mammals (including humans), their distribution in tissues and fluids, their possible cell targets, and the functional consequences of their infectivity on the reproductive and endocrine systems. The consequences of these viral infections on the reproductive tract and semen can be extremely serious in terms of organ integrity, development of pathological and cancerous processes, and transmission of diseases. Furthermore, of essential importance is the fact that viral infection of the testicular cells may result not only in changes in testicular function, a serious risk for the fertility and general health of the individual (such as a fall in testosteronemia leading to cachexia), but also in the possible transmission of virus-induced mutations to subsequent generations. In addition to providing an exhaustive account of the data available in these domains, this review focuses attention on the fact that the interface between endocrinology and virology has so far been poorly explored, particularly when major health, social and economical problems are posed. Our conclusions highlight the research strategies that need to be developed. Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system

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Section: The Animal Testissupporting

confidence: 64%

Section: Animal Semenmentioning

confidence: 99%

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Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

290

220

View full text Add to dashboard Cite

show abstract

“…Esto puede asociarse con la salida temprana de los viriones respecto a las otras dos cepas, lo cual es apoyado por los ensayos de RT-PCR. Sin embargo, PAC1 es un aislamiento obtenido de un brote neurológico y reproductivo que incluyó cerdos de todas las edades, en contraste con los hallazgos clíni-cos de la infección por PAC3, que involucró principalmente signos reproductivos en adultos durante la infección natural y también durante una infección experimental (Ramírez-Mendoza et al 1997, Reyes-Leyva et al 2002. Este hecho sugiere que las actividades HA y NA, así como el efecto citopático en cultivo celular no son suficientes para establecer el grado de virulencia entre estos dos aislamientos, sobre todo considerando que PAC1 es la cepa más virulenta in vivo.…”

Section: Discussionunclassified

“…Las cepas virales PAC1 (1991) y PAC3 (1992) se aislaron en el Departamento de Producción Animal "Cerdos" de la Facultad de Medicina Veterinaria de la UNAM (Ramírez-Mendoza et al 1997, ReyesLeyva et al 2002. La cepa prototipo LPM fue obtenida en 1984 por Moreno-López et al (1986).…”

Section: Materials Y Métodosunclassified

Caracterización biológica de tres aislamientos naturales del Rubulavirus porcino (México)

Borraz-Argüello¹,

Santos‐López²,

Vallejo-Ruíz³

et al. 2007

RBT

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Biological characterization of three natural isolates of the porcine rubulavirus (Mexico).Porcine rubulavirus (PoRV) produces a neurological and reproductive syndrome in pigs called the blue-eye disease, known only from Mexico. Several isolates were grouped by the main symptoms presented during outbreaks: a) neurotropic in piglets, b) broadly neurotropic in piglets and gonadotropic in adults, and c) gonadotropic in adults. We studied some biological properties of three strains, which fall in one of each virus group: La Piedad Michoacán (LPM) and Producción Animal Cerdos 1 (PAC1) and 3 (PAC3), respectively. The analyzed viral properties are mainly related with the trans-membrane hemagglutinin-neuraminidase (HN) and fusion (F) proteins, such as cytopathic effect, hemolysis, hemagglutinating (HA) and neuraminidase (NA) activities. In the infection assays PAC1 strain presented the highest fusogenicity level; however, the most cytolytic strain was PAC3. In addition, HA and NA activities and viral genome of PAC3 strain was detected in supernatants during cell infection earlier than in the other two strains, which shows that PAC3 virions release from the host cell earlier than LPM and PAC1. Experimental determination in purified viruses shows that PAC3 presented a higher HA and NA activities; however, PAC1 shows other interesting properties, such as a high thermostability of HN and differences about substrate profile respect to LPM and PAC3. Our data suggest that NA activity is associated with the virulence of RVP. Rev. Biol. Trop. 56 (2): 487-499. Epub 2008 June 30.

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Blue Eye Disease: Clinical Signs and Lesions

Stephano¹,

Morilla

Yoon

et al. 2002

Trends in Emerging Viral Infections of Swine

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Lesions in the reproductive tract of boars experimentally infected with porcine rubulavirus

Cited by 50 publications

References 10 publications

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Caracterización biológica de tres aislamientos naturales del Rubulavirus porcino (México)

Blue Eye Disease: Clinical Signs and Lesions

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