Lessons Learnt after the Introduction of the Seven Valent‑Pneumococcal Conjugate Vaccine Toward Broader Spectrum Conjugate Vaccines

Falup‐Pecurariu, Oana

doi:10.4103/2319-4170.104409

Cited by 15 publications

(10 citation statements)

References 55 publications

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“…Its effectiveness in preventing invasive pneumococcal disease (IPD) in infants and community-acquired pneumonia (CAP) has been clearly observed. However, it has been shown that the vaccine exerts a selective pressure on the serotypes not included in the vaccine [13]. This phenomenon of serotype replacement created a necessity for the development of new-generation recombinant protein vaccines, especially based on virulent factors conserved between strains [14].…”

Section: Introductionmentioning

confidence: 99%

Nonclassically Secreted Proteins as Possible Antigens for Vaccine Development: A Reverse Vaccinology Approach

Mudadu

Carvalho

Leclercq

2015

Appl Biochem Biotechnol

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Reverse vaccinology strategies have already been applied to a variety of microorganisms and have contributed significantly to vaccine development. However, most of the studies focused on an individual organism or on proteins with signature sequence motifs commonly found in known secreted proteins from bacteria. In this work, we applied a reverse vaccinology strategy based on conservation, virulence, and nonclassically surface exposure criterions to identify potential antigens in two microorganisms with significant degree of genomic plasticity among isolates (Streptococcus pneumoniae and Leptospira spp.), which imposes a major limitation to the production of a multistrain component vaccine. PSORTb 3.0.2 was run to predict the subcellular localization of the proteins. OrthoMCL was run to identify groups of the most conserved proteins between strains. Virulence prediction was done for the most conserved proteins, and SecretomeP was run to predict the nonclassically secreted proteins among the potential virulence factors. Based on the above criteria, we identified 37 proteins conserved between 16 genomes of S. pneumoniae and 12 proteins conserved between 5 leptospiral genomes as potential vaccine candidates.

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Section: Introductionmentioning

confidence: 99%

Nonclassically Secreted Proteins as Possible Antigens for Vaccine Development: A Reverse Vaccinology Approach

Mudadu

Carvalho

Leclercq

2015

Appl Biochem Biotechnol

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“…Similarly, an outbreak of penicillin-resistant S. pneumoniae in Spain in 2011 was rapidly contained in 2012 owing to the introduction of the 7-valent pneumococcal conjugate vaccine (Fig. 7B) [22]. Finally, the significant reduction in the prevalence of MRSA in the UK in 2011 clearly matches the efforts in this country to improve surveillance and to combat MRSA bacteraemia (Fig.…”

Section: Resultsmentioning

confidence: 88%

A computational model to monitor and predict trends in bacterial resistance

Alawieh

Sabra

Bizri

et al. 2015

Journal of Global Antimicrobial Resistance

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Current concern over the emergence of multidrug-resistant superbugs has renewed interest in approaches that can monitor existing trends in bacterial resistance and make predictions of future trends. Recent advances in bacterial surveillance and the development of online repositories of susceptibility tests across wide geographical areas provide an important new resource, yet there are only limited computational tools for its exploitation. Here we propose a hybrid computational model called BARDmaps for automated analysis of antibacterial susceptibility tests from surveillance records and for performing future predictions. BARDmaps was designed to include a structural computational model that can detect patterns among bacterial resistance changes as well as a behavioural computational model that can use the detected patterns to predict future changes in bacterial resistance. Data from the European Antimicrobial Resistance Surveillance Network (EARS-Net) were used to validate and apply the model. BARDmaps was compared with standard curve-fitting approaches used in epidemiological research. Here we show that BARDmaps can reliably predict future trends in bacterial resistance across Europe. BARDmaps performed better than other curve-fitting approaches for predicting future resistance levels. In addition, BARDmaps was also able to detect abrupt changes in bacterial resistance in response to outbreaks and interventions as well as to compare bacterial behaviour across countries and drugs. In conclusion, BARDmaps is a reliable tool to automatically predict and analyse changes in bacterial resistance across Europe. We anticipate that BARDmaps will become an invaluable tool both for clinical providers and governmental agencies to help combat the threat posed by antibiotic-resistant bacteria.

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“…The eff ectiveness of the new seven-valent pneumococcal conjugate vaccine in reducing disease burden and consequent unintended selection for the rise of serotypes that are not covered by the vaccine shows the importance of vaccination and continuous monitoring of target organisms. 380 Vaccines directed against organisms for which antibiotic resistance is especially challenging is a strategy that could have great clinical eff ect. Recent eff orts to develop vaccines for important drug resistant pathogens such as MRSA 381 and M tuberculosis 343,382 are promising, but have yet to generate viable candidates for late stage clinical trials.…”

Section: The Lancet Infectious Diseases Commissionmentioning

confidence: 99%

Antibiotic resistance—the need for global solutions

2014

Br Dent J

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The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences aff ect everybody in the world. Similarities with climate change are evident. Many eff orts have been made to describe the many diff erent facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to eff ective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed.

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Lessons Learnt after the Introduction of the Seven Valent‑Pneumococcal Conjugate Vaccine Toward Broader Spectrum Conjugate Vaccines

Cited by 15 publications

References 55 publications

Nonclassically Secreted Proteins as Possible Antigens for Vaccine Development: A Reverse Vaccinology Approach

Nonclassically Secreted Proteins as Possible Antigens for Vaccine Development: A Reverse Vaccinology Approach

A computational model to monitor and predict trends in bacterial resistance

Antibiotic resistance—the need for global solutions

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