Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Yan, Yuxiang; Wu, Lijuan; Zhang, Jie; Wang, Shuo; Wang, Wei; Dong, Jing; He, Yan

doi:10.1507/endocrj.ej15-0236

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…Associations between variation in pri‐miRNA and diseases have been reported in multiple studies. rs10877887 TC genotype in pri‐let‐7i conferred a significantly higher risk of metabolic syndrome when compared with TT genotype (Yan et al, 2015). rs531564 GG genotype in pri‐miR‐124‐1 may upregulate the expression of miR‐124, which is a cancer suppressor and eventually decrease the risk of esophageal squamous cell carcinoma (Zhang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Pri‐miR‐144 rs9279 is associated with type 2 diabetes and regulation of stress response

Yan

Xiao

Zhang

et al. 2020

Journal Cellular Physiology

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Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) may alter miRNA expression, binding affinity, and/or messenger RNA expression levels of the target genes, thus leading to disease susceptibility. This study explored the association between SNPs in neuroendocrine stress response-related miRNAs and type 2 diabetes (T2D). In the screening stage, the association between six candidate SNPs of miRNAs and T2D was analyzed in a case-control study including 504 T2D cases and 494 healthy controls. Homozygous GG genotype of pri-miR-144 rs9279 showed significant association with increased risk of T2D compared with homozygous TT genotype (adjusted odds ratio [OR] = 1.62, 95% confidence interval [CI]: 1.07-2.45; p = .023) and the combined TT/TG genotype (adjusted OR = 1.59, 95% CI: 1.08-2.36; p = .020). In the validation stage, the association was further validated in a second independent set of subjects. The GG genotype showed consistent directions and effect sizes that were identified in previous additive and recessive models. The expression levels of miRNAs were further compared between different genotypes in the 179 newly diagnosed cases and 183 frequency-matched healthy controls. As a result, the GG genotype carriers had significantly upregulated expression of plasma miR-144 and cortisol, as compared to individuals with TT and TG genotypes, respectively, in total subjects and subgroups (p < .05). Eventually, NR3C1 was proved to be a stress-related target gene of miR-144, indicating that pri-miR-144 rs9279 may contribute to the development of T2D by altering regulation of stress response.

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Section: Discussionmentioning

confidence: 99%

Pri‐miR‐144 rs9279 is associated with type 2 diabetes and regulation of stress response

Yan

Xiao

Zhang

et al. 2020

Journal Cellular Physiology

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“…16 Mutations, such as single nucleotide polymorphisms (SNPs), of miRNAs may also change miRNA and mRNA expression levels, thus leading to altered metabolic parameters. 17 On the other hand, the action of miRNA controls the translation of various messengers RNAs (mRNAs). Yan 18 found that increased levels of miRNA-18a and miR-34c can alter susceptibility to stress-related diseases by regulating GR and CRFR1 mRNA expression respectively, which…”

Section: Introductionmentioning

confidence: 99%

Identification of stress‐related microRNA biomarkers in type 2 diabetes mellitus: A systematic review and meta‐analysis

Liang

Xiao

et al. 2018

Journal of Diabetes

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“…Moreover, Jiang et al reported a relatively higher let‐7d expression in cultured myotubes in T2DM subjects than that in NGT (normal glucose‐tolerant) subjects ( p = .08) (Jiang et al, ). In 2015, Yan et al reported that although there were no associations of the let‐7d rs10993081 allele in the dominant and recessive inheritance models with T2DM, the A/G genotype of rs10993081 in let‐7d was associated with an increased risk of metabolic syndromes compared with AA genotypes ( p = .006; OR = 1.42, 95% CI: 1.11–1.83) (Yan et al, ). In the current study, we also did not find that rs10993081 and rs7045890 in let‐7d were associated with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms of miRNAs involved in the GLUT4 pathway in T2DM in a Chinese population

Yang

et al. 2019

Molec Gen & Gen Med

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Background The insulin/insulin receptor substrate (IRS)/phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt)/GLUT4 pathway plays a crucial role in insulin resistance and is closely associated with T2DM. Accumulating evidence indicates that miRNAs (such as miR‐135a, let‐7d, miR‐107, miR‐96, miR‐29a, miR‐23a, miR‐126, miR‐133a, and miR‐106b) influence the GLUT4 pathway. Methods A total of 784 subjects with T2DM and 846 nondiabetic subjects were enrolled and 12 single nucleotide polymorphisms (SNPs) in miRNAs (rs10459194 in miR‐135a‐2, rs10993081 and rs7045890 in let‐7d, rs2296616 in miR‐107, rs2402959 and rs6965643 in miR‐96, rs24168 in miR‐29a, rs3745453 in miR‐23a, rs4636297 in miR‐126, rs8089787 and rs9948906 in miR‐133a‐1 and rs999885 in miR‐106b) involved in the GLUT4 pathway were genotyped using the MassArray method in a Chinese population. Results Our data showed that the A allele of rs2402959 in miR‐96 may increase the risk of developing T2DM (p = .002, OR = 1.266; 95% CI: 1.089–1.471). The genotypes of rs3745453 in miR‐23a showed the difference between T2DM and control groups (p < .001). Moreover, for rs2402959, compared with the A/A genotype, the (G/A–G/G) genotype shows a protective effect in T2DM (p = .001, OR = 0.71; 95% CI: 0.58–0.87). For rs3745453, compared with the (A/A–A/G) genotype, the G/G genotype increases the risk of T2DM (p < .001, OR = 1.95; 95% CI: 1.38–2.77). In addition, we also found that rs4636297G/G genotype was associated with lower TC in T2DM group. Conclusion Our results revealed that genetic variations in the miRNAs involved in the GLUT4 pathway were associated with T2DM susceptibility in a Chinese population, and these results emphasize the need to study the functional effects of these variations in the miRNAs involved in the GLUT4 pathway on the risk of developing T2DM.

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Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Cited by 9 publications

References 34 publications

Pri‐miR‐144 rs9279 is associated with type 2 diabetes and regulation of stress response

Pri‐miR‐144 rs9279 is associated with type 2 diabetes and regulation of stress response

Identification of stress‐related microRNA biomarkers in type 2 diabetes mellitus: A systematic review and meta‐analysis

Association of single nucleotide polymorphisms of miRNAs involved in the GLUT4 pathway in T2DM in a Chinese population

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