Letter: diverticulosis in inflammatory bowel diseases

Tursi, Antonio; Elisei, Walter; Picchio, Marcello; Forti, Giacomo; Giorgetti, Gian Marco; Faggiani, Roberto; Zampaletta, Costantino; Brandimarte, Giovanni

doi:10.1111/apt.12656

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…21 Studies from the Mediterranean area also showed similar rates of diverticulosis. 23,24 East Asian studies demonstrated similar rates of diverticulosis. For example, a study in Taiwan reported a prevalence of diverticulosis of 13.5%; 25 and a recent study from Japan showed a prevalence of 20.3% among a large number of patients who underwent colonoscopic examination.…”

Section: Discussionmentioning

confidence: 84%

Relationship between diverticulosis and nonalcoholic fatty liver disease in elderly patients

et al. 2018

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ObjectiveTo compare clinical and laboratory features of elderly patients with and without diverticulosis and assess factors related to hepatosteatosis.MethodThis retrospective case–control study analysed the clinical and laboratory data, colonoscopy and abdominal ultrasonography records of patients >65 years who underwent colonoscopies. Subjects were categorized according to the presence and absence of colonic diverticulosis. Univariate/multivariate logistic regression analyses were performed to evaluate the independent predictive factors of hepatosteatosis.ResultsA total of 355 patients were enrolled in the study: 169 had colonic diverticulosis; and 186 without colonic diverticulosis formed the control group. Age, sex and chronic disorders associated with the metabolic syndrome did not differ between the diverticulosis and control groups. The rate of hepatosteatosis was lower in patients with diverticulosis compared with the control group (27% versus 42%, respectively). Diabetes mellitus, hyperlipidaemia and hepatosteatosis were more common among patients aged <75 years. In the multivariate logistic regression analysis, diverticulosis remained an independent predictor of hepatosteatosis (odds ratio 0.529; 95% confidence interval 0.323, 0.866). Other independent predictive factors in the multivariate analysis were triglyceride and albumin.ConclusionDiverticulosis in the elderly was found to be a negative predictor of hepatosteatosis. Higher values of albumin and triglyceride in conjunction with the absence of diverticulosis may be suggestive of nonalcoholic fatty liver disease in the elderly.

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Section: Discussionmentioning

confidence: 84%

Relationship between diverticulosis and nonalcoholic fatty liver disease in elderly patients

et al. 2018

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“…In Italy, two recent studies assessed diverticulosis prevalence. The first found a 19.4% prevalence on colonoscopy [Tursi et al 2014]; the second found a 51.4% prevalence on CT colonography [De Cecco et al 2015].…”

Section: Epidemiologymentioning

confidence: 99%

Diverticulosis today: unfashionable and still under-researched

Tursi

2015

Therap Adv Gastroenterol

101

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Diverticulosis of the colon is a widespread disease, and its prevalence is increasing especially in the developing world. The underlying pathological mechanisms that cause the formation of colonic diverticula remain unclear but are likely to be the result of complex interactions among age, diet, genetic factors, colonic motility, and changes in colonic structure. The large majority of patients remain asymptomatic throughout their life, one fifth of them become symptomatic (developing the so-called 'diverticular disease') while only a minority of these will develop acute diverticulitis. The factors predicting the development of symptoms remain to be identified. Again, it is generally recognized that diverticular disease occurrence is probably related to complex interactions among colonic motility, diet, lifestyle, and genetic features. Changes in intestinal microflora due to low-fiber diet and consequent low-grade inflammation are thought to be one of the mechanisms responsible for symptoms occurrence of both diverticular disease and acute diverticulitis. Current therapeutic approaches with rifaximin and mesalazine to treat the symptoms seem to be promising. Antibiotic treatment is currently advised only in acute complicated diverticulitis, and no treatment has currently proven effective in preventing the recurrence of acute diverticulitis. Further studies are required in order to clarify the reasons why diverticulosis occurs and the factors triggering occurrence of symptoms. Moreover, the reasons why rifaximin and mesalazine work in symptomatic diverticular disease but not in acute diverticulitis are yet to be elucidated.

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“…More recent studies have found out that diverticulosis prevalence was lower in IBD (12.3%) than in the control (19.4%) group (p < 0.001). 17 In conclusion, the prevalence of diverticulosis is lower in UC patients than in the general population. The exact mechanism responsible for this observation is yet to be assessed, but the role of chronic inflammation in determining this finding seems to be reasonable.…”

Section: Diverticular Disease and Chronic Idiopathic Inflammatory Bowmentioning

confidence: 81%

Management of Diverticular Disease in the Setting of Other Colorectal Pathology: Data on Simultaneous Issues in Segmental Colitis, Inflammatory Bowel Disease, Cancer, and Complications

Ghalyaie

2018

Clinics in Colon and Rectal Surgery

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Diverticulosis of the colon is a very common anatomical condition. In the Western world, it affects more than 70% of over 65 years old population and represents the fifth most important gastrointestinal disease in terms of health care costs in Western countries. The diagnosis of diverticular disease and diverticulitis can be challenging. Often, there is overlap with other colonic pathologies, such as segmental colitis, ischemia, inflammatory bowel disease, cancer, or infectious colitis. Management of diverticular disease in these settings might be different.

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Letter: diverticulosis in inflammatory bowel diseases

Cited by 8 publications

References 9 publications

Relationship between diverticulosis and nonalcoholic fatty liver disease in elderly patients

Relationship between diverticulosis and nonalcoholic fatty liver disease in elderly patients

Diverticulosis today: unfashionable and still under-researched

Management of Diverticular Disease in the Setting of Other Colorectal Pathology: Data on Simultaneous Issues in Segmental Colitis, Inflammatory Bowel Disease, Cancer, and Complications

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