Letter: third‐line rescue therapy with levofloxacin after failure of two treatments to eradicate <i>Helicobacter pylori</i> infection

Gisbert, Javier P.

doi:10.1111/j.1365-2036.2012.05117.x

Cited by 24 publications

(5 citation statements)

References 11 publications

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“…Evidence level: very low; Grade of recommendation: weak third-line therapy, if not used before [89][90][91] ( Fig. 1 ).…”

Section: Which Eradication Regimen Should Be Used In Case the Second-...mentioning

confidence: 99%

Management of Helicobacter pylori infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED)

Romano,

Gravina,

Eusebi

et al. 2022

Digestive and Liver Disease

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“…Evidence level: very low; Grade of recommendation: weak third-line therapy, if not used before [89][90][91] ( Fig. 1 ).…”

Section: Which Eradication Regimen Should Be Used In Case the Second-...mentioning

confidence: 99%

Management of Helicobacter pylori infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED)

Romano,

Gravina,

Eusebi

et al. 2022

Digestive and Liver Disease

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“…Triple therapy with PPI‐LEV‐AMO has been the most used rescue regimen in recent years due to its simplicity and its effectiveness, which is similar or superior to that of many versions of the classical BIS‐containing quadruple therapy . At our centre, the ITT effectiveness achieved with the PPI‐LEV‐AMO combination was slightly higher than those obtained in the most relevant Spanish multicentre studies that have evaluated this therapy as second‐line (73%) and third‐line (68%) . The fact that no significant differences were found between second‐ and third‐line treatments strengthens the notion that the success of this therapy can be maintained in successive eradication attempts as long as the patient has not previously received quinolones.…”

Section: Discussionmentioning

confidence: 53%

Empirical Helicobacter pylori rescue therapy: an 18‐year single‐centre study of 1200 patients

2019

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Background: Manychangeshavebeenmadetotheguidelinesonrescuetreatmentsfor Helicobacter pylori infection due to their poor effectiveness in clinical practice.Objective: To evaluate the use and effectiveness of different empirical rescue therapies for H. pylori infection in a specialised consultation unit over 18 years. Methods:Design: analysis of a systematic, prospective, single-centre data record.Patients: consecutive patients in whom at least one H. pylori eradication regimen had failed. Intervention: consecutive rescue therapies were prescribed empirically according to the best scientific evidence. Helicobacter pylori eradication was defined by a negative 13 C-ureabreathtest.Results: A total of 1200 subjects were included. Eleven different therapies were used during the study period, being the seven most common: proton pump inhibitor (PPI)-levofloxacin (LEV)-amoxicillin (AMO); PPI-bismuth(BIS)-LEV-AMO; PPI-moxifloxacin-AMO; ranitidine bismuth citrate-tetracycline-metronidazole; classical BIS (BIS)-containing quadruple therapy; PPI-Pylera ® and PPI-rifabutin (RIF)-AMO. The effectivenessofthesecond-,third-,fourth-andfifth-linerescuetherapieswas77%, 71%,60%and58%,respectively.Thecumulativeeffectivenessafterfiveconsecutive therapieswas99.8%.Thethreemosteffectivesecond-andthird-linetherapieswere: PPI-Pylera ® (96%and82%,respectively),classicalBIS-containingquadrupletherapy (92%and89%)andPPI-BIS-LEV-AMO(88%and84%). Conclusions: Helicobacter pylori eradication can be achieved virtually in all cases by the administration of several consecutive empirical therapies. The most effective second-linestrategyistheadministrationofaBIS-containingquadrupletherapy(either classical, Pylera ® or with LEV-AMO). The most effective third-line strategy is theadministrationofanotpreviouslyusedBIS-containingquadrupletherapy.Agood alternativeasafourth-linetherapyistheadministrationofPPI-RIF-AMO-BIS.

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“…After the failure of a treatment with first-line clarithromycin and another with second-line levofloxacin (which is the most common scenario in our setting), bismuth-containing quadruple therapy (PPI, bismuth, tetracycline, and metronidazole) [15] has achieved encouraging results as rescue treatment. For its part, after the failure of a first treatment with clarithromycin and a second quadruple line with bismuth, treatment with levofloxacin is recommended [16,15]. Given the dilemma about the effectiveness of antibiotics, lemon tea oil concentrate represents a treatment opportunity for those people who do not have positive effects on them.…”

Section: Fig 2 [mentioning

confidence: 99%

Effect of Lemon Oil Concentrate Cymbopogon citratus ERILIM® towards the Helicobacter pylori Bacteria: A Case Report

Ledezma

Vázquez

Hernandez

et al. 2022

EJMP

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This research is based on the effect of the lemon tea concentrate whose polyphenols are powerful antioxidants. Studies have shown that they suppress free radicals in a more effective way than vitamins C or E; in some of cases, specifically in H. pylori, which generally colonizes the human stomach as a single strain with stable characteristics. Authors mention that this colonization can be stable throughout life. This bacterium is related to chronic gastritis, and although H. pylori infection is still the main cause of duodenal and gastric ulcers, the prevalence of ulcers associated with H. pylori is decreasing, while that of related ulcers with non-steroidal anti-inflammatory drugs (NSAIDs) is increasing. Much of what has been published lately about H. pylori and has focused on its important changes in the pattern of the disease and in the potential value of eradication therapy.

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Letter: third‐line rescue therapy with levofloxacin after failure of two treatments to eradicate Helicobacter pylori infection

Cited by 24 publications

References 11 publications

Management of Helicobacter pylori infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED)

Management of Helicobacter pylori infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED)

Empirical Helicobacter pylori rescue therapy: an 18‐year single‐centre study of 1200 patients

Effect of Lemon Oil Concentrate Cymbopogon citratus ERILIM® towards the Helicobacter pylori Bacteria: A Case Report

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