Letter to the Editor Amiodarone-induced myxedema coma – a case and review of the literature

Amiodarone-induced myxoedema coma as a rare differential diagnosis of consciousness disturbance

“…[1][2][3][4][5] In this article, we describe a rare case of a MC in an elderly female under amiodarone therapy with no previous history of thyroid disease, which was successfully treated. Note.…”

“…Current studies suggest that amiodarone can be held in patients under concomitant levothyroxine therapy. [1] In conclusion, despite its rarity but considering the worldwide use of amiodarone as an anti-arrhythmic agent, we emphasize that amiodarone-induced myxoedema coma should be included in the differential diagnosis of consciousness disturbances. Although transient alterations may be seen in pa-tients under amiodarone therapy, close monitoring is crucial to look for clear changes in thyroid function.…”

“…[1] However, myxoedema coma (MC) secondary to amiodarone therapy has been sparsely reported. [1][2][3][4][5] Although it is usually seen in patients with underlying thyroid disease, it can be the first manifestation of hypothyroidism. Due to its systemic involvement, the mortality rate is high (up to 50%).…”

“…The incidence of amiodarone-induced hypothyroidism (AIH) is high, ranging from 2% to 34% according several studies. [1] Older age, female gender, a pre-existing autoimmune thyroid disease with elevated baseline TSH levels, among others, are risk factors for the development of AIH. [1] However, myxoedema coma (MC) secondary to amiodarone therapy has been sparsely reported.…”

“…[1] Older age, female gender, a pre-existing autoimmune thyroid disease with elevated baseline TSH levels, among others, are risk factors for the development of AIH. [1] However, myxoedema coma (MC) secondary to amiodarone therapy has been sparsely reported. [1][2][3][4][5] Although it is usually seen in patients with underlying thyroid disease, it can be the first manifestation of hypothyroidism.…”