Letter to the editor concerning the article ‘Safety of vaccines administration in hereditary fructose intolerance’

Saborido-Fiaño, R.; Martinón-Torres, Nazareth; Crujeiras-Martinez, Vanesa; Couce, María L.; Leis, Rosaura

doi:10.1080/21645515.2021.1891816

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…These are routinely administered at ages two months, four months, and six months, usually before a child is found to have HFI. Therefore, any child with vomiting, hypoglycemia, lethargy, or unexplained liver or kidney failure after rotavirus vaccination should be thoroughly investigated for the possibility of HFI [ 84 ].…”

Section: Etiologymentioning

confidence: 99%

Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives

et al. 2023

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Hypoglycemia is due to defects in the metabolic systems involved in the transition from the fed to the fasting state or in the hormone control of these systems. In children, hypoglycemia is considered a metabolic-endocrine emergency, because it may lead to brain injury, permanent neurological sequelae and, in rare cases, death. Symptoms are nonspecific, particularly in infants and young children. Diagnosis is based on laboratory investigations during a hypoglycemic event, but it may also require biochemical tests between episodes, dynamic endocrine tests and molecular genetics. This narrative review presents the age-related definitions of hypoglycemia, its pathophysiology and main causes, and discusses the current diagnostic and modern therapeutic approaches.

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Section: Etiologymentioning

confidence: 99%

Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives

et al. 2023

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“…There are considerable controversies about the safety concerns of vaccines that contain fructose, sucrose or sorbitol in HFI. Saborido-Fiaño et al [ 44 , 45 ] argue that the safe threshold of fructose was 2.4 mg/kg/dose and various oral rotavirus vaccines would not qualify for that category. This requires the need to revisit the vaccine content.…”

Section: Controversies In Managementmentioning

confidence: 99%

Hereditary fructose intolerance: A comprehensive review

Singh¹,

Sarma²

2022

WJCP

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Hereditary fructose intolerance (HFI) is a rare autosomal recessive inherited disorder that occurs due to the mutation of enzyme aldolase B located on chromosome 9q22.3. A fructose load leads to the rapid accumulation of fructose 1-phosphate and manifests with its downstream effects. Most commonly children are affected with gastrointestinal symptoms, feeding issues, aversion to sweets and hypoglycemia. Liver manifestations include an asymptomatic increase of transaminases, steatohepatitis and rarely liver failure. Renal involvement usually occurs in the form of proximal renal tubular acidosis and may lead to chronic renal insufficiency. For confirmation, a genetic test is favored over the measurement of aldolase B activity in the liver biopsy specimen. The crux of HFI management lies in the absolute avoidance of foods containing fructose, sucrose, and sorbitol (FSS). There are many dilemmas regarding tolerance, dietary restriction and occurrence of steatohepatitis. Patients with HFI who adhere strictly to FSS free diet have an excellent prognosis with a normal lifespan. This review attempts to increase awareness and provide a comprehensive review of this rare but treatable disorder.

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Vaccination strategies for people living with inborn errors of metabolism in Brazil

Ramos

Aranda

Cardona

et al. 2023

Jornal de Pediatria

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Letter to the editor concerning the article ‘Safety of vaccines administration in hereditary fructose intolerance’

Cited by 4 publications

References 6 publications

Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives

Hypoglycemia in Children: Major Endocrine-Metabolic Causes and Novel Therapeutic Perspectives

Hereditary fructose intolerance: A comprehensive review

Vaccination strategies for people living with inborn errors of metabolism in Brazil

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