Letter to the Editor: Fine‐needle aspiration cytology and core‐needle biopsy in the diagnosis of lymphadenopathies: Words of endorsement

Al‐Abbadi, Mousa A.; Barroca, Helena; Bode‐Lesniewska, Beata; Calaminici, Maria; Chhieng, David C.; Cozzolino, Immacolata; Ehiger, Mats; Field, Andrew; Geddie, William R.; Hosone, Masaru; Katz, Ruth L.; Lin, Oscar; Michelow, Pamela; Rajwanshi, Arwind; Schmitt, Fernando; Vielh, Philippe; Zeppa, Pio

doi:10.1111/ejh.13646

Cited by 17 publications

(18 citation statements)

References 8 publications

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“…The RS cells being overlooked and masked by the dominance of polymorphous infiltrates has been reported previously [14]. Other studies have reported that the predominance of neutrophils in a necrotic background in rare cases of HL can mimic suppurative lymphadenitis, as observed in our case [15–17]. Previous studies have also highlighted the difficulty in diagnosing lymphomas in cytopathology, especially in the presence of a reactive background [15–17].…”

Section: Discussionsupporting

confidence: 77%

The Application of the Proposed Sydney System for Reporting Lymph Node Cytopathology: A Five-Year Experience of an Academic Institution in South India

2023

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Introduction: Fine needle aspiration biopsy (FNAB) is a routinely used investigation in the evaluation of lymph node pathologies. However, there exists a lack of uniformity in cytopathology reporting owing to the non-availability of standard guidelines. Recently, a novel system for reporting lymph node cytopathology has been proposed. The present study aimed to analyze the utility of the proposed system in cytopathology reporting in our institution. Materials: FNAB of lymph nodes performed over a period of 5 years were categorized as per the proposed Sydney system. The diagnoses on cytopathology were correlated with histopathologic diagnoses to assess the diagnostic accuracy. The rate of malignancy (ROM) for each category was calculated. Results: A total of 747 lymph node FNABs were included in the study. Histopathology was available in 262 cases. ROM in categories I-V was 26.3%, 7.2%, 76.9%, 82.3%, and 100.0%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of FNAB when considering category L3 to represent benign cytopathology were 84.2%, 97.5%, 97.1%, and 86.2%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of FNAB when considering category L3 to represent malignant cytopathology were 92.56%, 95.08%, 94.9%, and 92.8% respectively. Conclusion: The study substantiates the usefulness of the proposed Sydney system in lymph node cytopathology in enhancing better communication between clinicians and cytopathologists. The use of ancillary techniques like immunocytochemistry and flow cytometry will aid in arriving at a more precise diagnosis.

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Section: Discussionsupporting

confidence: 77%

The Application of the Proposed Sydney System for Reporting Lymph Node Cytopathology: A Five-Year Experience of an Academic Institution in South India

2023

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“…LN-FNAC is the object of an ongoing debate [13,[55][56][57][58][59][60]. Proponents of LN-FNAC argue that it is a safe, cheap, minimally invasive, and accurate procedure that can sometimes be used in place of more expensive or invasive exams, such as core-needle biopsy or surgical biopsy [56,61].…”

Section: Discussionmentioning

confidence: 99%

Cytological Diagnosis of Aggressive Small-Cell Lymphomas

et al. 2022

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Background: Despite their sometimes deceivingly bland appearance, some small-cell lymphomas are very aggressive and the prognosis of patients depends on a prompt diagnosis that allows the initiation of appropriate therapy. Summary: The present review discusses the salient cytological features of the most common aggressive small-cell lymphomas and then proceeds to analyze their main diagnostic criteria, including the usage of ancillary techniques. Key Messages: Lymph node fine-needle aspiration cytology is a fast, safe, cheap, minimally invasive, and accurate procedure that can be used for a prompt and accurate diagnosis of lymphomas.

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“…We considered Al-Abbadi and colleagues' comments about the role of lymph node core needle biopsy (LNCB) and fine needle cytology (LNFNC) for the diagnosis of lymphadenopathies. 1 While we understand the Authors' arguments, we still think that they do not justify the systematic use of LNCB/LNFNC as first diagnostic approach.…”

Section: Author S' Replymentioning

confidence: 97%

Lymph node core needle biopsy in lymphoproliferative disorders—Authors’ reply to Al‐Abbadi and colleagues

Pizzi

Agostinelli

Santoro

et al. 2021

European J of Haematology

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Letter to the Editor: Fine‐needle aspiration cytology and core‐needle biopsy in the diagnosis of lymphadenopathies: Words of endorsement

Cited by 17 publications

References 8 publications

The Application of the Proposed Sydney System for Reporting Lymph Node Cytopathology: A Five-Year Experience of an Academic Institution in South India

The Application of the Proposed Sydney System for Reporting Lymph Node Cytopathology: A Five-Year Experience of an Academic Institution in South India

Cytological Diagnosis of Aggressive Small-Cell Lymphomas

Lymph node core needle biopsy in lymphoproliferative disorders—Authors’ reply to Al‐Abbadi and colleagues

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