Letter to the Editor

Baiocchi, Otavio C. G.; Colleoni, Gisele W. B.; Rodrigues, Christiane de Arruda; Barton, Desmond P.J.; Kerbauy, Fábio R.; Garcia, Reynaldo Jesus; Segreto, Roberto Araújo; Alves, Antonio C.; Bordin, José Orlando

doi:10.1080/1042819031000110937

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…According to Coley’s criteria [8], primary bone lymphoma should have: 1) a primary focus in a single bone; 2) positive histological diagnosis; and 3) no evidence of distant soft tissue or distant lymph node involvement. Regional lymph node involvement at diagnosis is not considered as an exclusion criterion [9,10]. Recently, multiple bone involvement was also recognized as primary bone lymphoma, as long as the other 2 criteria are met [9].…”

Section: Discussionmentioning

confidence: 99%

Primary Bone Lymphoplasmacytic Lymphoma Presenting with Spinal Cord Compression: A Case Report

Yang¹,

Li²,

Su³

et al. 2013

tjh

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Primary bone lymphoma is a rare disease, and the main pathological type is diffuse large B-cell lymphoma. The occurrence of follicular, marginal zone and lymphoplasmacytic lymphomas is rare. Vertebras are also sites that can be affected, and spinal cord compression is reported in 14% of patients with vertebral involvement. However, there is no report on primary vertebral lymphoplasmacytic lymphoma with spinal cord compression. The present report presents one case of primary vertebral lymphoplasmacytic lymphoma with spinal cord compression and increased serum and urine λ light chain, without an elevated heavy chain of immunoglobulin.Conflict of interest:None declared.

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Section: Discussionmentioning

confidence: 99%

Primary Bone Lymphoplasmacytic Lymphoma Presenting with Spinal Cord Compression: A Case Report

Yang¹,

Li²,

Su³

et al. 2013

tjh

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“…Radiotherapy achieved high levels of local control (80–100%) but was followed by a high late relapse rate (50%) [5]. Then different CMT schedules of chemotherapy and radiotherapy were proposed [7, 15, 16, 22, 23]. It has been shown that anthracycline-based therapy improves the response rate and prolongs OS of patients with localized lymphomas [23].…”

Section: Discussionmentioning

confidence: 99%

Results of a Prospective Study of High-Dose or Conventional Anthracycline-Cyclophosphamide Regimen Plus Radiotherapy for Localized Adult Non-Hodgkin’s Primary Bone Lymphoma

Tanguy‐Schmidt

Houot

Lissandre

et al. 2014

Advances in Hematology

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Background. Primary bone lymphoma (PBL) is a rare entity that has only been reviewed in one prospective and small retrospective studies, from which it is difficult to establish treatment guidelines. We prospectively evaluated high-dose or conventional anthracycline-cyclophosphamide dose and radiotherapy for PBL. Patients and Methods. The GOELAMS prospective multicenter study (1986–1998) enrolled adults with localized high-grade PBL according to age and performance status (PS). Patients <60 years received a high-dose CHOP regimen (VCAP) and those ≥60 years a conventional anthracycline-cyclophosphamide regimen (VCEP-bleomycin); all received intrathecal chemotherapy and local radiotherapy. Results. Among the 26 patients included (VCAP: 19; VCEP-bleomycin: 7), 39% had poor PS ≥2. With a median follow-up of 8 years, overall survival, event-free survival, and relapse-free survival were 64%, 62%, and 65%, respectively, with no significant difference between treatment groups. Poor PS was significantly associated with shorter OS and EFS. Conclusions. Our results confirm the efficacy of our age-based therapeutic strategy. High-doses anthracycline-cyclophosphamide did not improve the outcome. VCEP-bleomycin is effective and well tolerated for old patients. The intensification must be considered for patients with PS ≥2, a poor prognostic factor.

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Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement

et al. 2017

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BackgroundSkeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.MethodsWe analyzed clinical characteristics and outcome of 75 patients with DLBCL and SI in order to identify factors with prognostic impact towards progression-free survival (PFS) and overall survival (OS).ResultsLimited stage disease (Ann Arbor stage IE-IIE) was present in 34 patients (45%), 41 patients (55%) had advanced stage disease (Ann Arbor stage IIIE-IVE). Outcome was generally favorable for patients with DLBCL and SI with 3-year OS of 83%. The international prognostic index (IPI) was able to distinguish between different risk groups within this specific entity. Additionally, hypercalcemia showed to be a factor significantly associated with inferior survival. In regard to first-line treatment modalities, consolidative radiotherapy was positively associated with prolonged PFS and OS while intensification of chemotherapy had no significant impact.ConclusionsIn our cohort of patients with DLBCL and SI, high-risk IPI as well as presence of hypercalcemia were associated with inferior outcome. Consolidative radiotherapy had a positive impact on survival.

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Letter to the Editor

Cited by 3 publications

References 6 publications

Primary Bone Lymphoplasmacytic Lymphoma Presenting with Spinal Cord Compression: A Case Report

Primary Bone Lymphoplasmacytic Lymphoma Presenting with Spinal Cord Compression: A Case Report

Results of a Prospective Study of High-Dose or Conventional Anthracycline-Cyclophosphamide Regimen Plus Radiotherapy for Localized Adult Non-Hodgkin’s Primary Bone Lymphoma

Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement

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