Letter to the Editor on Type 1 diabetes onset triggered by COVID-19

Sholihah, Mentari Maratus; Kusuma, Taufik Ridwan Hadi; Hanif, Muhammad Ifham; Prabowo, Nurhasan Agung

doi:10.1007/s00592-021-01761-3

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Type 2 diabetes mellitus (T2DM) patients with uncontrolled glucose levels are particularly vulnerable to bacterial infections 1,2 . A bacterial infection causes blood sugar levels to become uncontrollably high.…”

Section: Introductionmentioning

confidence: 99%

Diabetic Ketoacidosis and Acute Coronary Syndrome Due to Neck Abscess

Prabowo

Dewi

Nugraha

et al. 2022

MRAJ

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Diabetic ketoacidosis (DKA) is a life-threatening consequence of diabetes mellitus. Infection is the most common cause of DKA. A 41-year-old man came to the hospital emergency department with shortness of breath the day before, nausea, vomiting, coughing, pain and swelling in the left neck. The patient has a history of uncontrolled diabetes. A physical examination revealed Kussmaul's breathing and a lump the size of a tennis ball on the left side of his neck. Laboratory findings are: leukocytosis, an increase in blood sugar of 512 mg/dL; blood gas analysis shows acidosis, ketone examination reveals ketonuria; Electrocardiography shows waves of ischemic heart disease, with elevated Hs Troponin. Fine needle examination of the lump shows a neck abscess. The patient was diagnosed with DKA in type 2 diabetes mellitus, with the acute coronary syndrome and neck abscess. Surgical debridement, antibiotics, acute coronary syndrome therapy, and DKA therapy are treatments. The patient responded well to treatment.

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Section: Introductionmentioning

confidence: 99%

Diabetic Ketoacidosis and Acute Coronary Syndrome Due to Neck Abscess

Prabowo

Dewi

Nugraha

et al. 2022

MRAJ

View full text Add to dashboard Cite

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Response to Comment on Marchand et al. Type 1 diabetes onset triggered by COVID-19; and follow-up of the case

Marchand

Luyton

2021

Acta Diabetol

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COVID-19 as a Trigger for Type 1 Diabetes

Wang

Guo

Wang

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Type 1 diabetes (T1D) is usually caused by immune-mediated destruction of islet beta-cells, and genetic and environmental factors are thought to trigger autoimmunity. Convincing evidence indicates that viruses are associated with T1D development and progression. During the coronavirus disease 2019(COVID-19) pandemic, cases of hyperglycemia, diabetic ketoacidosis (DKA), and new diabetes increased, suggesting that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may be a trigger for or unmask T1D. Possible mechanisms of beta-cell damage include virus-triggered cell death, immune-mediated loss of pancreatic beta-cells, and damage to beta-cells due to infection of surrounding cells. This article examines the potential pathways by which SARS-CoV-2 affects islet beta-cells in the above three aspects. Specifically, we emphasize that T1D can be triggered by SARS-CoV-2 through several autoimmune mechanisms, including epitope spread, molecular mimicry and bystander activation. Given that the development of T1D is often a chronic, long-term process, it is difficult to currently draw firm conclusions as to whether SARS-CoV-2 causes T1D. This area needs to be focused on in terms of the long-term outcomes. More in-depth and comprehensive studies with larger cohorts of patients and long-term clinical follow-ups are required.

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Letter to the Editor on Type 1 diabetes onset triggered by COVID-19

Cited by 3 publications

References 5 publications

Diabetic Ketoacidosis and Acute Coronary Syndrome Due to Neck Abscess

Diabetic Ketoacidosis and Acute Coronary Syndrome Due to Neck Abscess

Response to Comment on Marchand et al. Type 1 diabetes onset triggered by COVID-19; and follow-up of the case

COVID-19 as a Trigger for Type 1 Diabetes

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