Letter to the Editor

Mf, González-Escribano; Yélamos, José; García-Lozano,; Moreno, I.; García, Alicia; Núñez‐Roldán, Antonio; Sánchez, Berta

doi:10.1111/j.1399-0039.1995.tb02419.x

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Nosotros habíamos descrito previamente una asociación entre el gen HLA-DRBl'03 y la respuesta procesamiento y presentación de los alergenos sigue la vía endosórnica, utilizando las moléculas HLA clase II, los productos de los genes TAP pueden participar en el transporte de los péptidos exógenos, en un proceso dependiente de las molé-culas HLA clase 1 (24). Además, algunos péptidos endógenos pueden ser presentados por molécu-las HLA clase II, dependiendo de la proteína transportadora TAP (25,26).…”

Section: Discussionunclassified

Los genes TAP y EMP2 en el asma alérgica

Martínez

Caraballo

1997

biomedica

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ResumenLos pacientes con asma alérgica presentan una fuerte respuesta de IgE contra los alergenos de ácaros; por tanto, estudiar la inmunogenética de esta respuesta podría ayudar a entender la etiología de las enfermedades alérgicas. El asma alérgica es una enfermedad muy común en el trópico, siendo los principales agentes causales los ácaros Blomia tropicalis y Dermatophagoidespteronyssinus. En la población mulata de Cattagena, hemos descrito previamente asociaciones entre los genes HLA clase II y la respuesta de IgE a los alergenos de ácaros en pacientes asmáticos.Los genes TAP y LMP intervienen en el procesamiento antigénico pero su posible papel en la patogénesis de asma alérgica no está bien documentada. En este estudio, evalyamos el efecto del polimorfismo de los genes TAP y LMP en el control de la respuesta de IgE específica contra alergenos de ácaros en dos grupos: 96 pacientes asmáticos no relacionados y 97 controles no alérgicos, pertenecientes al grupo étnico mulatos. La tipificación deTAPl y TAP2 fue hecha por PCWSSO y del gen LMP2 por PCWRFLP. La frecuencia de cada alelo en pacientes con asma alérgica y controles fue: TAP*0101: 52,6-56,2%; TAP*02011: 35,9-34,9%; TAPe0301 : 5,2-3,8%; TAP*0401: 6,3-4,7%; TAP2A: 31,5-30,5%; TAPZB: 44,3-46,6%; TAP2C: 16,5-18,0%; TAP 2H: 7,7-4,9%; LMP2*HIH: 6,7-10,4%; LMP2*WR: 42,7-44,8%; LMPZWH: 50,6-44,8%.No hubo ninguna diferencia estadísticamente significativa en la distribución de estos alelos entre los dos grupos estudiados. Además, no hallamos desequilibrio de ligamiento entre estos genes y los alelos HLA DRB1. Estos hallazgos sugieren que los genes TAP y LMP2 no están comprometidos primariamente con la susceptibilidad genética del asma alérrgica. SummaryPatients with mite-induced allergic asthma (AA) present strong IgE-response to mite allergens. Thus, immunogenetic study of this response could help in the understanding of allergic disease etiology. AA is a common disease in the Tropics, Blomia tropicalis and Dermatophagoides pteronyssinus being the principal causative agents. An association between HLA class II genes and IgE-response to mite allergens in AA patients from the prevalent ethnic mulatto group in Cartagena, a Caribbean city, has already been described (by these authors), the main vector being Blomia tropicalis. TAP and LMP genes play an important part in antigen processing but their possible role in AA pathogenesis has not been well-documented. In this study, the role of TAP and LMP2 polymorphism in the control of specific IgE-response to mite allergens has been evaluated in two groups, consisting of 96 unrelated asthmatic patients with IgE-response to mite allergens and 97 non-allergic controls belonging to the mulatto ethnic group. TAPl and TAP2 were typed by PCRISSO; LMP2 was typed by PCRIRFLP. Each alleles' frequency in AA patients and controls was:

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Section: Discussionunclassified

Los genes TAP y EMP2 en el asma alérgica

Martínez

Caraballo

1997

biomedica

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“…Wordsworth et al ( 5 ) reported a decrease in TAP2B and an increase in TAP2D in Caucasian RA. Gonzalez-Escribano et al (8) observed an increase in TAPlB in DR4-negative RA and a decrease in TAP2B in DR4-positive RA. In Japanese RA, neither a decrease in TAP2B nor an increase in TAPlB was observed.…”

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confidence: 95%

“…A contribution of TAP to HLA class 11-restricted endogenous processing has also been reported (4). Associations of TAP genes with RA have been reported in Caucasian patients with RA (5)(6)(7)(8). We studied Japanese RA patients to clarify the contribution of TAP genes to the disease, and we dis-ULISS tlie association of TAP with the susceptible MLA-DKB 1 W405 gene, Ninety-two unrelated randomly selected Japanese RA patients aged 55.1k11.7 (meankSD) (82 women and 10 men), 82 (90%) of whom were positive for rheumatoid factor (RAF), were examined and compared with 95 healthy controls.…”

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Polymorphism of TAP1 and TAP2 in Japanese patients with rheumatoid arthritis

Takeuchi

Nakano²,

Matsuta³

et al. 1997

Tissue Antigens

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Contribution of polymorphism of transporter associated with antigen processing 1 and 2 (TAP1 and 2) alleles to pathogenesis of Japanese rheumatoid arthritis (RA) was studied in 92 RA patients by PCR-RFLP. The allele frequency of TAP2A was slightly low (38.0%) and the frequencies of TAP2B and TAP2C were slightly high (39.7% and 17.9%) in RA, but these differences were not significant. These increases and decrease were due to the positive or negative associations with HLA-DRB1*0405. It was very likely that slight differences in TAP2A, TAP2B and TA2C in RA were secondary phenomenon reflecting an increase in HLA-DRB1*0405. The prevalence of TAP2E allele was low (3.3%, P < 0.01, Pc = not significant) and not correlated with HLA-DRB1*0405.

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Letter to the Editor

Cited by 2 publications

References 3 publications

Los genes TAP y EMP2 en el asma alérgica

Los genes TAP y EMP2 en el asma alérgica

Polymorphism of TAP1 and TAP2 in Japanese patients with rheumatoid arthritis

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