Letters to the Editor

Rožmanić,; Banac, Srdjan; Ivosević, D; Čače, Neven

doi:10.1111/j.1440-1754.2006.00946.x

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…The majority of studies reported a high dose of at least 100 mg/kg/d [11,12,23,28,30,31,34,35,38]. Four studies reported a daily dose of 50-100 mg/kg [18,[34][35][36]. Pseudolithiasis occurred even in daily doses under 60 mg/kg/d [35] (Table 1).…”

Section: Biliary Tract Lithiasismentioning

confidence: 99%

“…Tuna Kirsaclioglu et al observed that ceftriaxone could lead to stable gallstones and complicating diseases, such as cholecystitis [20]. Fasting (with lithiasis reported in the first week of administration), bed rest (lithiasis reported during the first 5 days), feeding habits, and activity patterns are the factors considered to affect lithiasis [11,36]. A family history of lithiasis has been reported as an important risk factor for the formation of gallstones [36].…”

Section: Biliary Tract Lithiasismentioning

confidence: 99%

“…Fasting (with lithiasis reported in the first week of administration), bed rest (lithiasis reported during the first 5 days), feeding habits, and activity patterns are the factors considered to affect lithiasis [11,36]. A family history of lithiasis has been reported as an important risk factor for the formation of gallstones [36]. Although ceftriaxone is often used with other drugs, it has been exclusively associated with lithiasis [23,26,33] (Table 1).…”

Section: Biliary Tract Lithiasismentioning

confidence: 99%

See 2 more Smart Citations

Ceftriaxone Administration Associated with Lithiasis in Children: Guilty or Not? A Systematic Review

Louta

Kanellopoulou

Alexopoulou-Prounia

et al. 2023

JPM

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Lithiasis is a known side effect of ceftriaxone administration in children. Sex, age, weight, dosage, and duration of intake have been reported as risk factors for the formation of calcification or stones in the bile and urine excretory systems of children who received ceftriaxone. The purpose of this systematic review is to investigate the reported effects of ceftriaxone administration in pediatric patients who were admitted to a hospital due to infection, the likelihood of gallstones, nephroliths, or precipitations in both the biliary and urinary systems, as well as investigate the relationship with their mother’s history during pregnancy. Original studies and literature reviews from the PubMed database were included in the study. No time limit related to research or publication was set for the articles. The results were evaluated, aiming to understand the outcomes and identify any predisposing factors relevant to this side effect. Of the 181 found articles, 33 were appropriate for inclusion in the systematic review. The administered dose of ceftriaxone presented variability. Symptoms, such as abdominal pain and vomiting, were associated with ceftriaxone-related lithiasis in many cases. It was noted that most of the results were the outcomes of retrospective observation and not of prospective randomized research. Definitively, more randomized control studies with long-term outcomes are needed to identify the exact association between ceftriaxone and lithiasis in children.

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Section: Biliary Tract Lithiasismentioning

confidence: 99%

Section: Biliary Tract Lithiasismentioning

confidence: 99%

Section: Biliary Tract Lithiasismentioning

confidence: 99%

See 1 more Smart Citation

Ceftriaxone Administration Associated with Lithiasis in Children: Guilty or Not? A Systematic Review

Louta

Kanellopoulou

Alexopoulou-Prounia

et al. 2023

JPM

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Ceftriaxone‐associated biliary pseudolithiasis in children: do we know enough?

Cuzzolin

Oggiano

Clemente

et al. 2020

Fundamemntal Clinical Pharma

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Ceftriaxone is an antibiotic agent frequently used in paediatric hospital practice for the treatment of severe bacterial infections. The use of this agent can result in cholelithiasis and/or biliary sludge, more commonly in children than in adults. This systematic review was aimed at analysing available literature concerning ceftriaxone‐associated biliary pseudolithiasis in paediatric patients, with a special emphasis on the clinical aspects. A literature analysis was performed using Medline and Embase electronic databases (articles published in English up to December 2019), with the search terms and combinations as follows:’ceftriaxone’, ‘cholelithiasis’, ‘biliary sludge’ ‘gallstones’ ‘neonates’ ‘children’ ‘clinical aspects’ ‘management’. Several case reports, case series and prospective/retrospective studies have documented a relationship between ceftriaxone treatment and biliary pseudolithiasis in the paediatric population, even though literature data regarding neonates and infants are scarce. Ceftriaxone‐associated biliary pseudolithiasis is dose‐dependent and usually asymptomatic but, sometimes, it may present with abdominal pain, nausea and emesis. Abdominal ultrasonography should be performed when this complication is suspected. Generally, ceftriaxone‐associated cholelithiasis resolves over a variable period of time (days to months) after cessation of therapy. Therefore, a conservative approach to this condition is advocated, but a prolonged follow‐up may be necessary. A personalized assessment of factors predisposing to ceftriaxone‐associated biliary pseudolithiasis before prescribing the drug can allow to minimize the risk of developing it, with significant advantages in terms of human and economic costs.

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