Leucine Content of Proteins and Foodstuffs<sup>1,2</sup>

Brand, Erwin; Ryan, Francis J.; Diskant, Eugene M.

doi:10.1021/ja01225a039

Cited by 12 publications

(1 citation statement)

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“…Intravenous injection of chymotrypsin alone has no significant effect on the blood sugar of these animals (70). By microbiological methods 13.4 per cent leucine (71,72) and 17.5 per cent glutamic acid (73,74) were found to be present in insulin. Attention has been drawn to the possible errors in the insulin assay technique which is based upon the production of convulsions in mice (75), and the cross-over method of insulin assay (76) has been further developed.…”

Section: Insulinmentioning

confidence: 94%

The Chemistry of the Hormones

Selye¹,

Jensen²

1946

Annu. Rev. Biochem.

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Although some very important publications concerning the chem istry of the hormones appeared during the past year, the volume of the pertinent literature was small. The chemistry of the steroids, the physiologic actions of hormones and their metabolism will be discussed by others; hence this chapter deals merely with the chemistry of the nonsteroid hormones and only cursory reference will be made to allied fields. PITUITARY Young (1) has reviewed the functions of the anterior pituitary gland and Houssay (2) described the relation of this endocrine organ to experimental diabetes. Lactogenic hormone.-Studies concerning the reaction between ketene and lactog�nic hormone in buffer solutions of pH 4.0 and pH 7.0 at 0° C. showed that an acetylated lactogenic hormone ex hibits a diminished crop-sack stimulating action in pigeons. From this it was concluded that the amino groups are essential for the bio logic activity of the hormone (3). The relative viscosity of lactogenic hormone solutions has been determined in the presence of urea and of a detergent. (Nacconol). An increase in viscosity was found to coincide with a lowering of biologic activity (4). The factors in fluencing the reliability of the biologic assay of lactogenic preparations have been analyzed (5, 6) in pigeons by the crop-sack weight method.Thyrotropic hormone.-A procedure for obtaining highly purified thyrotropic preparations has been described in detail (7). One�. of the material thus obtained produced definite histologic changes in the thyroids of three-day-old male white Leghorn chicks; it is free of prolactin, gonadotropic and growth activity. The thyrotropic hormone content of the anterior pituitary of female albino mice was found to

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Section: Insulinmentioning

confidence: 94%