Leucocyte antigens in man: A comparison of lymphocytotoxic and agglutination assays for their detection

Bodmer, JG; Bodmer, W F; Payne, Rudolph; Terasaki, P; Vredevoe, Donna L.

doi:10.1097/00007890-196611000-00024

Cited by 10 publications

(13 citation statements)

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“…This lends support to the hypothesis that the systems are identical. The distribution of the phenotypes in the population reported by Bodmer et al [2] for the LA groups are similar to those reported here for the PIB1 and PIB3 groups (Table Via). A comparison of P1B1 and P1B2 groups with LA2 and LAI gives % = 10.1 with P < 0.02 indicating that P1B2 is probably not the same as LAI.…”

Section: Discussionsupporting

confidence: 89%

“…It will be noted that the entries in Table X are larger than those which could be calculated from the formula given by Bodmer and Payne [2]. This difference arises as Bodmer and Payne are calculat ing n for a situation where the data agree exactly with one hypo thesis, whereas, here account is taken of the possibility that observa tions may deviate by chance from expectations based on a correct hypothesis.…”

Section: Numerical Examplementioning

confidence: 87%

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An Extension of the P1^B Platelet Antigen System in Man

Gabb¹

1968

Vox Sanguinis

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Results of typing platelet specimens from 299 random group 0 blood donors with three antibodies agree with the hypothesis that the antigens detected are controlled by three alleles present in Caucasian populations with frequencies of 0.276, 0.109, 0.179. These alleles are denoted by P1^B1, P1^B2 and P1^B3 respectively. The remaining 43.6% of alleles at this locus P1^B- are not detectable with antibodies discussed in this paper. Tests on twelve families with a total of 34 children support this hypothesis. Evidence is presented from population data supporting the hypothesis that P1^B1 and P1^B3 are identical or closely related to LA2 and LAI respectively. Population data also supports the hypothesis that P1^B2 and P1B3 correspond to 7^d and 7^c respectively. In the appendix of this paper a description is given of a statistical technique that demonstrates the number of specimens from a population that should be typed in order to distinguish between the hypotheses of allelism and independence of genes controlling blood group antigens.

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Section: Discussionsupporting

confidence: 89%

Section: Numerical Examplementioning

confidence: 87%

An Extension of the P1^B Platelet Antigen System in Man

Gabb¹

1968

Vox Sanguinis

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show abstract

“…Results of the blind cytotoxicity tests were then compared to those by leukoagglutination. Correspondence with Payne's results was remarkably close [4]. Of a total of 146 reactions tested, 88% were concordant and 12% discordant.…”

Section: Resultssupporting

confidence: 58%

“…Whether similar groups are shown by the more recently developed lymphocyte cytotoxicity reaction [19,22,28,29] remains to be shown. Some evidence has been presented [4] that lymphotoxic reactions detect the LA 1 and LA 2 groups of Payne and Bodmer [15]. This report describes the resolution of cytotoxicity reaction patterns em ploying computer analysis in a manner similar to Van Rood's study of leukocyte antigens [24,25].…”

mentioning

confidence: 90%

Serotyping for Homotransplantation IV Grouping and Evaluation of Lymphotoxic Sera*

Terasaki¹,

Mickey²,

Verdevoe³

et al. 1966

Vox Sanguinis

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“…This was in spite of the fact that the cytotoxicity assay used only lymphocytes, not all the white blood cells, and depended on complement-dependent killing rather than agglutination. The key observation was that the same types identified by agglutination could be identified by the lymphocyte microcytotoxicity assay (10).…”

Section: Early Days Of Hlamentioning

confidence: 96%