Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions

Richens, Elizabeth R.; Williams, M. J.; Gough, K. R.

doi:10.1136/gut.15.1.19

Cited by 20 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In these diseases immune mechanism may be important and abnormalities of humoral immunity (Bregman and Kirsner, 1960;Perlmann et al, 1967) and cellular immunity (Bendixen, 1967;Shorter et al, 1969;Perlmann and Broberger 1973;Richens et al, 1974) have been described. Immune complexes have been found in the serum (Jewell and MacLennan, 1973) and in the bowel wall (Koffler et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Histopathology of cell mediated immune reaction in mouse colon--allograft rejection.

Holden¹,

Ferguson²

1976

Gut

View full text Add to dashboard Cite

SUMmARY Grafts of mouse fetal colon, implanted beneath the renal capsule of adult hosts, have been used to study the growth and development of colonic isografts and the rejection of colonic allografts. Isografts grew normally and maintained a structure similar to normal colon. Grafts between strains with H2 histocompatibility differences were rejected by 13 days after transplantation. Early progressive infiltration of the grafts by lymphoid cells was followed by increasing damage to, and subsequent loss of, the epithelial cell layer and destruction of the underlying muscle, changes which parallel those seen in rejection of skin and small bowel. The increase in survival time which is seen in allografts between strains with H2 identity was longer in the colon than has been seen in the skin or small bowel; none of the allografts of colon were completely rejected before 30 days, and some remained viable at 50 days. Comparison of the appearances of rejection in the colon withthose of ulcerative colitis and colonic Crohn's disease does not show the striking similarity which is seen between small bowel rejection and coeliac disease. Many of the individual features of these diseases are, however, present in the course of colonic rejection.

show abstract

Section: Discussionmentioning

confidence: 99%

Histopathology of cell mediated immune reaction in mouse colon--allograft rejection.

Holden¹,

Ferguson²

1976

Gut

View full text Add to dashboard Cite

show abstract

“…There is some evidence that a cell-mediated immune reaction tends to inhibit local humoral immune mechanisms (Feldmann, 1973); there is histological and other evidence to suggest that a cell-mediated immune reaction occurs in the bowel of patients with Crohn's disease (Dykes, 1970;Richens, Williams, Gough, and Ancill, 1974a), albeit possibly a disordered and ineffective one (Aluwihare, 1972;Richens et al, 1974b), and it could therefore be argued that this locally inhibits synthesis of IgA. On the other hand, it is at least equally possible that the reduction in IgA-containing cells is due to a deflection of circulating primed lymphocytes away from the affected areas; the localization of these cells to the gut in germ-free animals is thought to be mediated by a surface receptor recognition system (Griscelli, Vassalli, and McCluskey, 1969;Hall and Smith, 1970), a process termed 'ecotaxis' by de Sousa (1971).…”

Section: Discussionmentioning

confidence: 99%

The distribution of mucosal antibodies in the bowel of patients with Crohn's disease.

Green¹,

Fox²

1975

Gut

View full text Add to dashboard Cite

“…Impaired neutrophil influx to, and subsequent clearance of, a bacterial stimulus in CD has been attributed to defective secretion of pro-inflammatory cytokines by macrophages [7, 9, 10]. When isolated in vitro, chemotaxis and migration in neutrophils from patients with quiescent CD appears preserved [11, 12].…”

Section: Introductionmentioning

confidence: 99%

The Neutrophil Respiratory Burst and Bacterial Digestion in Crohn’s Disease

et al. 2010

View full text Add to dashboard Cite

The significant reduction in neutrophil RB in CD does not appear to result in defective bacterial digestion and is therefore unlikely play a major role in pathogenesis. Three patients in this cohort of patients with presumed idiopathic CD were found to have a profound defect of the neutrophil RB. A high index of suspicion for such patients is prudent, as their prognosis can be improved by altering or augmenting the conventional treatment regimens employed for CD.

show abstract

Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions

Cited by 20 publications

References 12 publications

Histopathology of cell mediated immune reaction in mouse colon--allograft rejection.

Histopathology of cell mediated immune reaction in mouse colon--allograft rejection.

The distribution of mucosal antibodies in the bowel of patients with Crohn's disease.

The Neutrophil Respiratory Burst and Bacterial Digestion in Crohn’s Disease

Contact Info

Product

Resources

About