1999
DOI: 10.1093/molehr/5.6.581
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Leukaemia inhibitory factor gene mutations in infertile women

Abstract: The glycoprotein leukaemia inhibitory factor (LIF) is produced by the endometrium and is involved in the control of implantation. In women with unexplained infertility reduced uterine concentrations of LIF have been reported. Studies with mice lacking a functional LIF gene have shown that the LIF protein is essential for implantation of the embryo. We have developed a method for screening of gene mutations in the coding region and critical regulatory regions of the LIF gene. Thus we could screen nulligravid in… Show more

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Cited by 95 publications
(45 citation statements)
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“…Intriguingly, gene-targeting experiments revealed that LIF plays an unequivocal role in blastocyst implantation in mice (Stewart et al 1992, Escary et al 1993. LIF is also associated with infertility in humans; reduced uterine concentration of LIF and point mutations of the LIF gene leading to aberrant interaction of LIF with LIFR have been described in infertile women (Laird et al 1997, Giess et al 1999. While the importance of LIF for implantation is well documented, information regarding its receptor utilization and its site of action in heterogeneous uterine cell types during the attachment reaction is limited.…”
Section: Discussionmentioning
confidence: 99%
“…Intriguingly, gene-targeting experiments revealed that LIF plays an unequivocal role in blastocyst implantation in mice (Stewart et al 1992, Escary et al 1993. LIF is also associated with infertility in humans; reduced uterine concentration of LIF and point mutations of the LIF gene leading to aberrant interaction of LIF with LIFR have been described in infertile women (Laird et al 1997, Giess et al 1999. While the importance of LIF for implantation is well documented, information regarding its receptor utilization and its site of action in heterogeneous uterine cell types during the attachment reaction is limited.…”
Section: Discussionmentioning
confidence: 99%
“…LIFR and gp130 are expressed in the luminal epithelium at this time, indicating a role for LIF signaling in preparing the human uterus for blastocyst attachment (15). In addition, decreased endometrial LIF production may be a factor in some cases of human infertility (17)(18)(19). An effective LIF antagonist could therefore prevent blastocyst implantation in women.…”
mentioning
confidence: 97%
“…At least two polymorphisms in the LIF gene (the rs929271 SNP in the 3'-untranslated region and the Val64Met polymorphism have been shown to be overrepresented in young (< 35 years) women with idiopathic infertility and in sub-fertile young women (signified by a history of fertility treatments other than IVF) [43,91,92]. At the same time, carriership of the variant allele of the rs929271 LIF polymorphism was reported to be associated with increased ongoing pregnancy rates after IVF [93].…”
Section: Reproductive Outcomes and Individual Repair Capacitymentioning
confidence: 99%