Leukämieerzeugung durch ein filtrierbares Agens aus malignen Tumoren

Transmission of a Filterable Agent from Rat Leukaemia Induced by X-Ray Irradiation and Treatment with Methylcholanthrene

“…This agent, probably a virus, can be activated by X-irradiation or by chemical carcinogens. On the other hand, many experimental findings suggest that oncogenic viruses may be of endogenic origin (2,5,9,17). They may arise from the cytoplasmatic organes, such as the endoplasmic reticulum, in consequence of their mutational changes (1,3).…”

The Transferability and Growth of the Shay Chloroleukaemia of the Rat

“…Concerning the similarity between human and rat chloroleukaemias, another puzzling fact may be mentioned : It is well known that chloroleukaemia may be produced in rats or mice by the ino culation of different cell-free material obtained from animals with leukaemia or even from tumours of non-haematopoietic origin (13)(14)(15), which observations strongly suggest a viral origin of the chloro leukacmic and leukaemic disease.…”

The In Vitro and In Vivo Analysis of Mammalian Tumour Viruses

“…Dr. A. Graffi kindly sent us some mice (passage SOV 16) that had developed chloroleukaemia as a result of inoculation with a virus that had originally been isolated by him from the Ehrlich tumour (Graffi, Bielka and Fey, 1956). Using our standard medium, Swiss embryo monolayers were inoculated with suspensions of (1) lymph nodes and spleen, and (2) brain, from a leukaemic mouse with markedly green lymph nodes.…”

“…and Beck, 1958), and in the last few years, viruses have been reported as responsible for some other types of leukaemia (Graffi, Bielka and Fey, 1956;Friend, 1957;Schoolman et al, 1957), parotid tumours and sarcomas (Gross, 1953(Gross, , 1955Stewart 1955), and various other neoplasms in mice and hamsters (Stewart et al, 1957(Stewart et al, , 1958Eddy et al, 1958a).…”